Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135759519> ?p ?o ?g. }
- W3135759519 endingPage "118" @default.
- W3135759519 startingPage "109" @default.
- W3135759519 abstract "Angiogenesis is critical for tissue healing and regeneration. Promoting angiogenesis in materials implanted within dental pulp after pulpectomy is a major clinical challenge in endodontics. We demonstrate the ability of acellular self-assembling peptide hydrogels to create extracellular matrix mimetic architectures that guide in vivo development of neovasculature and tissue deposition. The hydrogels possess facile injectability, as well as sequence-level functionalizability. We explore the therapeutic utility of an angiogenic hydrogel to regenerate vascularized pulp-like soft tissue in a large animal (canine) orthotopic model. The regenerated soft tissue recapitulates key features of native pulp, such as blood vessels, neural filaments, and an odontoblast-like layer next to dentinal tubules. Our study establishes angiogenic peptide hydrogels as potent scaffolds for promoting soft tissue regeneration in vivo. STATEMENT OF SIGNIFICANCE: A major challenge to endodontic tissue engineering is the lack of in situ angiogenesis within intracanal implants, especially after complete removal of the dental pulp. The lack of a robust vasculature in implants limit integration of matrices with the host tissue and regeneration of soft tissue. We demonstrate the development of an acellular material that promotes tissue revascularization in vivo without added growth factors, in a preclinical canine model of pulp-like soft-tissue regeneration. Such acellular biomaterials would facilitate pulp revascularization approaches in large animal models, and translation into human clinical trials." @default.
- W3135759519 created "2021-03-15" @default.
- W3135759519 creator A5017747595 @default.
- W3135759519 creator A5019735341 @default.
- W3135759519 creator A5025630534 @default.
- W3135759519 creator A5026542289 @default.
- W3135759519 creator A5036013612 @default.
- W3135759519 creator A5042086881 @default.
- W3135759519 creator A5047992889 @default.
- W3135759519 creator A5050133145 @default.
- W3135759519 creator A5056613652 @default.
- W3135759519 creator A5068259211 @default.
- W3135759519 creator A5086039900 @default.
- W3135759519 creator A5089354504 @default.
- W3135759519 date "2021-05-01" @default.
- W3135759519 modified "2023-10-06" @default.
- W3135759519 title "Angiogenic hydrogels for dental pulp revascularization" @default.
- W3135759519 cites W1504922538 @default.
- W3135759519 cites W1969949307 @default.
- W3135759519 cites W1972609083 @default.
- W3135759519 cites W1987964412 @default.
- W3135759519 cites W1989144555 @default.
- W3135759519 cites W1992112921 @default.
- W3135759519 cites W1993991546 @default.
- W3135759519 cites W2007310752 @default.
- W3135759519 cites W2017763556 @default.
- W3135759519 cites W2019274501 @default.
- W3135759519 cites W2025381299 @default.
- W3135759519 cites W2025921479 @default.
- W3135759519 cites W2030632477 @default.
- W3135759519 cites W2034073329 @default.
- W3135759519 cites W2042130427 @default.
- W3135759519 cites W2053175960 @default.
- W3135759519 cites W2066181296 @default.
- W3135759519 cites W2067291571 @default.
- W3135759519 cites W2073970540 @default.
- W3135759519 cites W2084538405 @default.
- W3135759519 cites W2090059131 @default.
- W3135759519 cites W2100358568 @default.
- W3135759519 cites W2102021823 @default.
- W3135759519 cites W2102069687 @default.
- W3135759519 cites W2109916620 @default.
- W3135759519 cites W2110008698 @default.
- W3135759519 cites W2145040826 @default.
- W3135759519 cites W2147822820 @default.
- W3135759519 cites W2166804282 @default.
- W3135759519 cites W2178716325 @default.
- W3135759519 cites W2275236309 @default.
- W3135759519 cites W2332501062 @default.
- W3135759519 cites W2344345384 @default.
- W3135759519 cites W2526445427 @default.
- W3135759519 cites W2560816184 @default.
- W3135759519 cites W2564477258 @default.
- W3135759519 cites W2588486673 @default.
- W3135759519 cites W2620833969 @default.
- W3135759519 cites W2743282411 @default.
- W3135759519 cites W2743742472 @default.
- W3135759519 cites W2747262318 @default.
- W3135759519 cites W2767026035 @default.
- W3135759519 cites W2772092278 @default.
- W3135759519 cites W2788081998 @default.
- W3135759519 cites W2792501144 @default.
- W3135759519 cites W2799819035 @default.
- W3135759519 cites W2800178728 @default.
- W3135759519 cites W2806784315 @default.
- W3135759519 cites W2883400436 @default.
- W3135759519 cites W2888250189 @default.
- W3135759519 cites W2888443411 @default.
- W3135759519 cites W2889115500 @default.
- W3135759519 cites W2895196944 @default.
- W3135759519 cites W2897416652 @default.
- W3135759519 cites W2900459227 @default.
- W3135759519 cites W2911621072 @default.
- W3135759519 cites W2945319642 @default.
- W3135759519 cites W2946325510 @default.
- W3135759519 cites W2952481429 @default.
- W3135759519 cites W2953732912 @default.
- W3135759519 cites W2966598528 @default.
- W3135759519 cites W2966668280 @default.
- W3135759519 cites W2993437868 @default.
- W3135759519 cites W3000157756 @default.
- W3135759519 cites W3004101080 @default.
- W3135759519 cites W3011412174 @default.
- W3135759519 cites W3015678043 @default.
- W3135759519 cites W3035232865 @default.
- W3135759519 cites W3082822866 @default.
- W3135759519 cites W3092335706 @default.
- W3135759519 cites W3097424092 @default.
- W3135759519 cites W4210961063 @default.
- W3135759519 cites W4211147424 @default.
- W3135759519 cites W4252179483 @default.
- W3135759519 doi "https://doi.org/10.1016/j.actbio.2021.03.001" @default.
- W3135759519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8096688" @default.
- W3135759519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33689817" @default.
- W3135759519 hasPublicationYear "2021" @default.
- W3135759519 type Work @default.
- W3135759519 sameAs 3135759519 @default.
- W3135759519 citedByCount "29" @default.