FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135772752> ?p ?o ?g. }

• W3135772752 endingPage "88" @default.
• W3135772752 startingPage "79" @default.
• W3135772752 abstract "Colorectal cancer (CRC) is one of the most common cancers. The aim of our study was to explore its related mutations, identify novel mutation markers, and construct predictive models for postoperative CRC patients, so as to provide evidence for the diagnosis, treatment, and prognosis of CRC.A total 50 CRC patients were collected, and the mutations in tissue samples were detected through next-generation sequencing (NGS). Meanwhile, 246 CRC cases with complete mutation data were downloaded from The Cancer Genome Atlas (TCGA) database. Afterwards, the co-mutations in both clinical and TCGA cohorts were identified, and the high-frequency mutation genes were selected. Subsequently, functional enrichment analysis was performed, and overall survival (OS) and progression-free survival (PFS) predictive models were constructed.In all, 18 out of 238 co-mutation genes mutated in at least 20% of the samples and were selected out as common high-frequency mutation genes. They were significantly enriched in 460 Gene Ontology (GO) terms and 87 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways (P<0.05), which were closely related to the occurrence and development of CRC. Among the 18 genes, NOTCH3, histone lysine methyltransferase 2C (KMT2C), and cAMP-response element binding protein-BP (CREBBP) were respectively associated with tumor position, stage, and PFS (P<0.05), and could be considered as potential biomarkers of CRC. Finally, OS and PFS predictive models were constructed and verified using the 50 clinical cases, with both models demonstrating high fitting degrees useful for predicting the OS and PFS of CRC patients.NOTCH3, KMT2C, and CREBBP were found to be prospective biomarkers for the diagnosis and prognosis of CRC. The prognosis prediction models had high sensitivity and could be used to predict the OS and PFS of CRC patients." @default.
• W3135772752 created "2021-03-15" @default.
• W3135772752 creator A5002532582 @default.
• W3135772752 creator A5004325176 @default.
• W3135772752 creator A5005177677 @default.
• W3135772752 creator A5041851608 @default.
• W3135772752 creator A5051363890 @default.
• W3135772752 date "2021-02-01" @default.
• W3135772752 modified "2023-10-17" @default.
• W3135772752 title "Prognosis model of colorectal cancer patients based on NOTCH3, KMT2C, and CREBBP mutations" @default.
• W3135772752 cites W1583158213 @default.
• W3135772752 cites W1690174620 @default.
• W3135772752 cites W1963810199 @default.
• W3135772752 cites W1984164650 @default.
• W3135772752 cites W2029449177 @default.
• W3135772752 cites W2030367937 @default.
• W3135772752 cites W2075410690 @default.
• W3135772752 cites W2088296450 @default.
• W3135772752 cites W2151034879 @default.
• W3135772752 cites W2153747194 @default.
• W3135772752 cites W2171015871 @default.
• W3135772752 cites W2211837538 @default.
• W3135772752 cites W2314651004 @default.
• W3135772752 cites W2520609209 @default.
• W3135772752 cites W2569086487 @default.
• W3135772752 cites W2591087130 @default.
• W3135772752 cites W2607183382 @default.
• W3135772752 cites W2886331240 @default.
• W3135772752 cites W2889646458 @default.
• W3135772752 cites W2889779047 @default.
• W3135772752 cites W2922109171 @default.
• W3135772752 cites W2922272514 @default.
• W3135772752 cites W2923648042 @default.
• W3135772752 cites W2947189347 @default.
• W3135772752 cites W2987968285 @default.
• W3135772752 cites W2999417355 @default.
• W3135772752 cites W3006260860 @default.
• W3135772752 cites W3012727437 @default.
• W3135772752 cites W3018550950 @default.
• W3135772752 doi "https://doi.org/10.21037/jgo-21-28" @default.
• W3135772752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7944156" @default.
• W3135772752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33708426" @default.
• W3135772752 hasPublicationYear "2021" @default.
• W3135772752 type Work @default.
• W3135772752 sameAs 3135772752 @default.
• W3135772752 citedByCount "6" @default.
• W3135772752 countsByYear W31357727522022 @default.
• W3135772752 countsByYear W31357727522023 @default.
• W3135772752 crossrefType "journal-article" @default.
• W3135772752 hasAuthorship W3135772752A5002532582 @default.
• W3135772752 hasAuthorship W3135772752A5004325176 @default.
• W3135772752 hasAuthorship W3135772752A5005177677 @default.
• W3135772752 hasAuthorship W3135772752A5041851608 @default.
• W3135772752 hasAuthorship W3135772752A5051363890 @default.
• W3135772752 hasBestOaLocation W31357727521 @default.
• W3135772752 hasConcept C104317684 @default.
• W3135772752 hasConcept C121608353 @default.
• W3135772752 hasConcept C126322002 @default.
• W3135772752 hasConcept C143998085 @default.
• W3135772752 hasConcept C150194340 @default.
• W3135772752 hasConcept C152724338 @default.
• W3135772752 hasConcept C2987395477 @default.
• W3135772752 hasConcept C501734568 @default.
• W3135772752 hasConcept C502942594 @default.
• W3135772752 hasConcept C526805850 @default.
• W3135772752 hasConcept C54355233 @default.
• W3135772752 hasConcept C71924100 @default.
• W3135772752 hasConcept C86803240 @default.
• W3135772752 hasConceptScore W3135772752C104317684 @default.
• W3135772752 hasConceptScore W3135772752C121608353 @default.
• W3135772752 hasConceptScore W3135772752C126322002 @default.
• W3135772752 hasConceptScore W3135772752C143998085 @default.
• W3135772752 hasConceptScore W3135772752C150194340 @default.
• W3135772752 hasConceptScore W3135772752C152724338 @default.
• W3135772752 hasConceptScore W3135772752C2987395477 @default.
• W3135772752 hasConceptScore W3135772752C501734568 @default.
• W3135772752 hasConceptScore W3135772752C502942594 @default.
• W3135772752 hasConceptScore W3135772752C526805850 @default.
• W3135772752 hasConceptScore W3135772752C54355233 @default.
• W3135772752 hasConceptScore W3135772752C71924100 @default.
• W3135772752 hasConceptScore W3135772752C86803240 @default.
• W3135772752 hasIssue "1" @default.
• W3135772752 hasLocation W31357727521 @default.
• W3135772752 hasLocation W31357727522 @default.
• W3135772752 hasLocation W31357727523 @default.
• W3135772752 hasOpenAccess W3135772752 @default.
• W3135772752 hasPrimaryLocation W31357727521 @default.
• W3135772752 hasRelatedWork W184793361 @default.
• W3135772752 hasRelatedWork W1923384484 @default.
• W3135772752 hasRelatedWork W1964572291 @default.
• W3135772752 hasRelatedWork W1984964356 @default.
• W3135772752 hasRelatedWork W2123060905 @default.
• W3135772752 hasRelatedWork W2159482845 @default.
• W3135772752 hasRelatedWork W2352732738 @default.
• W3135772752 hasRelatedWork W2559588208 @default.
• W3135772752 hasRelatedWork W2969443468 @default.
• W3135772752 hasRelatedWork W4318778067 @default.
• W3135772752 hasVolume "12" @default.

• next