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- W3135800131 endingPage "104812" @default.
- W3135800131 startingPage "104812" @default.
- W3135800131 abstract "Differently substituted β-hydroxy- and β-amino dialkyl and alkyl-aryl tellurides and selenides have been prepared through ring-opening reactions of epoxides and aziridines with selenium- or tellurium-centered nucleophiles. The antioxidant properties and the cytotoxicity of such compounds have been investigated on normal human dermal fibroblasts. Most of the studied compounds exhibited a low cytotoxicity and a number of them proved to be non-toxic, not showing any effect on cell viability even at the highest concentration used (100 μM). The obtained results showed a significant antioxidant potential of the selected organotellurium compounds, particularly evident under conditions of exogenously induced oxidative stress. The antioxidant activity of selenium-containing analogues of active tellurides has also been evaluated on cells, highlighting that the replacement of Se with Te brought about a significant increase in the peroxidase activity." @default.
- W3135800131 created "2021-03-15" @default.
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- W3135800131 date "2021-05-01" @default.
- W3135800131 modified "2023-10-16" @default.
- W3135800131 title "Synthesis of functionalised organochalcogenides and in vitro evaluation of their antioxidant activity" @default.
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- W3135800131 doi "https://doi.org/10.1016/j.bioorg.2021.104812" @default.
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