FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135800461> ?p ?o ?g. }

• W3135800461 endingPage "1327" @default.
• W3135800461 startingPage "1317" @default.
• W3135800461 abstract "Abstract Aim To explore the proliferation, adhesion and differentiation response and the underlying mechanisms that occur in lipopolysaccharide (LPS)‐induced inflamed dental pulp cells (DPCs) in contact with Biodentine and mineral trioxide aggregate (MTA). Methodology The DPCs were isolated from three healthy donors and named DPC‐H1 to DPC‐H3. The DPCs were pre‐cultured with 2 or 5 μg mL −1 LPS for 24 h to induce inflammation. The expression of inflammation marker miR‐146a was detected by q‐PCR. The normal and LPS‐induced DPCs were further treated with 0.14 mg mL −1 Biodentine or 0.13 mg mL −1 MTA for 24 h. MTT assay and adhesion assay were used to analyse the changes of cell phenotypes. DSPP, AKT and ERK expressions were detected by Western blotting. The data were analysed by Mann–Whitney test or two‐way anova . Differences were considered statistically significant when P < 0.05. Results In LPS‐induced DPCs, Biodentine and MTA treatment neither induced nor aggravated LPS‐induced inflammation, but their presence did increase the expression of the odontogenic differentiation marker DSPP. Under 2 or 5 μg mL −1 LPS‐induced inflammation, Biodentine and MTA promoted the proliferation of DPC cells, and significantly in DPC‐H2 ( P < 0.0001 for both reagents). With the treatment of 2 μg mL −1 LPS, the cell adhesion of DPCs on the fibronectin‐coated culture plates was increased significantly by Biodentine ( P = 0.0413) and MTA ( P < 0.0001). Biodentine and MTA regulated cell adhesion on the fibronectin‐coated culture plates ( P < 0.0001 for both reagents) and proliferation ( P < 0.0001 for both reagents) via the AKT pathway. However, the AKT pathway was not involved in the expression of DSPP induced by Biodentine and MTA. Conclusion Biodentine and MTA enhanced the proliferation, adhesion and differentiation of LPS‐induced DPCs. The proliferation and adhesion process induced by Biodentine and MTA was via the AKT pathway. However, the cellular differentiation process might not use the same pathway, and this needs to be explored in future studies." @default.
• W3135800461 created "2021-03-15" @default.
• W3135800461 creator A5005811575 @default.
• W3135800461 creator A5006608753 @default.
• W3135800461 creator A5050528726 @default.
• W3135800461 creator A5077659211 @default.
• W3135800461 creator A5082830058 @default.
• W3135800461 creator A5091826022 @default.
• W3135800461 date "2021-03-30" @default.
• W3135800461 modified "2023-10-18" @default.
• W3135800461 title "The molecular functions of Biodentine and mineral trioxide aggregate in lipopolysaccharide‐induced inflamed dental pulp cells" @default.
• W3135800461 cites W1823755123 @default.
• W3135800461 cites W1873411329 @default.
• W3135800461 cites W1973653947 @default.
• W3135800461 cites W1975174220 @default.
• W3135800461 cites W1975872621 @default.
• W3135800461 cites W1993410470 @default.
• W3135800461 cites W2017315028 @default.
• W3135800461 cites W2021926216 @default.
• W3135800461 cites W2029260748 @default.
• W3135800461 cites W2044892809 @default.
• W3135800461 cites W2051941815 @default.
• W3135800461 cites W2063052160 @default.
• W3135800461 cites W2063794759 @default.
• W3135800461 cites W2070209856 @default.
• W3135800461 cites W2079767601 @default.
• W3135800461 cites W2101619948 @default.
• W3135800461 cites W2103554755 @default.
• W3135800461 cites W2109380802 @default.
• W3135800461 cites W2122740046 @default.
• W3135800461 cites W2124322436 @default.
• W3135800461 cites W2129665717 @default.
• W3135800461 cites W2172035295 @default.
• W3135800461 cites W2306550569 @default.
• W3135800461 cites W2514758118 @default.
• W3135800461 cites W2616550717 @default.
• W3135800461 cites W2749296808 @default.
• W3135800461 cites W2794302286 @default.
• W3135800461 cites W2808439730 @default.
• W3135800461 cites W2809407873 @default.
• W3135800461 cites W2836367517 @default.
• W3135800461 cites W2884261134 @default.
• W3135800461 cites W2888918871 @default.
• W3135800461 cites W2892195332 @default.
• W3135800461 cites W2893058683 @default.
• W3135800461 cites W2901833490 @default.
• W3135800461 cites W2906600289 @default.
• W3135800461 cites W2922082686 @default.
• W3135800461 cites W2928336389 @default.
• W3135800461 cites W2950604682 @default.
• W3135800461 cites W2953970397 @default.
• W3135800461 cites W3016616349 @default.
• W3135800461 doi "https://doi.org/10.1111/iej.13513" @default.
• W3135800461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33711171" @default.
• W3135800461 hasPublicationYear "2021" @default.
• W3135800461 type Work @default.
• W3135800461 sameAs 3135800461 @default.
• W3135800461 citedByCount "6" @default.
• W3135800461 countsByYear W31358004612022 @default.
• W3135800461 crossrefType "journal-article" @default.
• W3135800461 hasAuthorship W3135800461A5005811575 @default.
• W3135800461 hasAuthorship W3135800461A5006608753 @default.
• W3135800461 hasAuthorship W3135800461A5050528726 @default.
• W3135800461 hasAuthorship W3135800461A5077659211 @default.
• W3135800461 hasAuthorship W3135800461A5082830058 @default.
• W3135800461 hasAuthorship W3135800461A5091826022 @default.
• W3135800461 hasConcept C104317684 @default.
• W3135800461 hasConcept C1491633281 @default.
• W3135800461 hasConcept C153911025 @default.
• W3135800461 hasConcept C161312837 @default.
• W3135800461 hasConcept C185592680 @default.
• W3135800461 hasConcept C188442228 @default.
• W3135800461 hasConcept C199343813 @default.
• W3135800461 hasConcept C203014093 @default.
• W3135800461 hasConcept C2776914184 @default.
• W3135800461 hasConcept C2777090975 @default.
• W3135800461 hasConcept C2778754761 @default.
• W3135800461 hasConcept C2780783641 @default.
• W3135800461 hasConcept C55493867 @default.
• W3135800461 hasConcept C62112901 @default.
• W3135800461 hasConcept C71924100 @default.
• W3135800461 hasConcept C85265743 @default.
• W3135800461 hasConcept C85789140 @default.
• W3135800461 hasConcept C86492073 @default.
• W3135800461 hasConcept C86803240 @default.
• W3135800461 hasConceptScore W3135800461C104317684 @default.
• W3135800461 hasConceptScore W3135800461C1491633281 @default.
• W3135800461 hasConceptScore W3135800461C153911025 @default.
• W3135800461 hasConceptScore W3135800461C161312837 @default.
• W3135800461 hasConceptScore W3135800461C185592680 @default.
• W3135800461 hasConceptScore W3135800461C188442228 @default.
• W3135800461 hasConceptScore W3135800461C199343813 @default.
• W3135800461 hasConceptScore W3135800461C203014093 @default.
• W3135800461 hasConceptScore W3135800461C2776914184 @default.
• W3135800461 hasConceptScore W3135800461C2777090975 @default.
• W3135800461 hasConceptScore W3135800461C2778754761 @default.
• W3135800461 hasConceptScore W3135800461C2780783641 @default.
• W3135800461 hasConceptScore W3135800461C55493867 @default.

• next