FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135800535> ?p ?o ?g. }

• W3135800535 endingPage "42" @default.
• W3135800535 startingPage "33" @default.
• W3135800535 abstract "Metformin is associated with a reduced incidence and growth of abdominal aortic aneurysms (AAAs). The aim of the present study was to investigate the inhibitory effects of metformin on AAA development and possible underlying mechanisms in experimentally induced AAAs in mice, along with the possible synergistic effects of metformin and imatinib.Angiotensin II was used to induce AAAs in apolipoprotein E knockout (ApoE-/- ) mice for 28 days. The mice were treated with metformin (n = 11), metformin combined with imatinib (n = 7), or vehicle (n = 12), starting 3 days before angiotensin II infusion. Ultrasound examination was used to analyze aneurysm formation. Cholesterol and blood pressure levels were measured at the start and end of the study. Gene array and quantitative polymerase chain reaction were used to analyze the changes in gene expression in the aorta. Wire myography was used to study vascular function.Metformin (n = 11) suppressed the formation and progression of AAAs by 50% compared with the vehicle controls (n = 12), with no further effects from imatinib (n = 7). Metformin reduced total cholesterol and mRNA expression of SPP1 (encoding osteopontin), MMP12, and the glycoprotein genes Gpnmb and Clec7a. Furthermore, metformin inhibited blood pressure increases and reduced vascular contractions, as determined by wire myography, and restored the anticontractile function of perivascular adipose tissue.Metformin inhibited aneurysm formation and progression and normalized vascular function in ApoE-/- mice with no additional effect of imatinib. This might be mediated by the protective effects on vascular endothelial function and perivascular adipose tissue via reduced expression of genes promoting inflammation, including SPP1, MMP12, Gpnmb, and Clec7a.Retrospective studies of the effects of metformin in patients with aneurysm have so far only been performed of those with type 2 diabetes. The present study shows that metformin has effects on nondiabetic mice and revealed the mechanistic effects mediated by the drug that could also be important to study as outcomes in humans. Future clinical trials using metformin are warranted in patients without diabetes with abdominal aortic aneurysms." @default.
• W3135800535 created "2021-03-15" @default.
• W3135800535 creator A5004241415 @default.
• W3135800535 creator A5009935207 @default.
• W3135800535 creator A5021388716 @default.
• W3135800535 creator A5029419578 @default.
• W3135800535 creator A5039036487 @default.
• W3135800535 creator A5047772842 @default.
• W3135800535 creator A5054836912 @default.
• W3135800535 creator A5068493192 @default.
• W3135800535 creator A5071794395 @default.
• W3135800535 date "2021-01-01" @default.
• W3135800535 modified "2023-09-29" @default.
• W3135800535 title "Inhibition of angiotensin-induced aortic aneurysm by metformin in apolipoprotein E–deficient mice" @default.
• W3135800535 cites W1622431244 @default.
• W3135800535 cites W1979217617 @default.
• W3135800535 cites W1980410924 @default.
• W3135800535 cites W1987280936 @default.
• W3135800535 cites W1994815880 @default.
• W3135800535 cites W2006519499 @default.
• W3135800535 cites W2031565266 @default.
• W3135800535 cites W2037187996 @default.
• W3135800535 cites W2052402508 @default.
• W3135800535 cites W2052860092 @default.
• W3135800535 cites W2058298189 @default.
• W3135800535 cites W2063699934 @default.
• W3135800535 cites W2094325843 @default.
• W3135800535 cites W2098033604 @default.
• W3135800535 cites W2099276421 @default.
• W3135800535 cites W2126173974 @default.
• W3135800535 cites W2143381614 @default.
• W3135800535 cites W2147891699 @default.
• W3135800535 cites W2149602039 @default.
• W3135800535 cites W2161663914 @default.
• W3135800535 cites W2243930861 @default.
• W3135800535 cites W2253736653 @default.
• W3135800535 cites W2289196382 @default.
• W3135800535 cites W2333650350 @default.
• W3135800535 cites W2338299575 @default.
• W3135800535 cites W2511762120 @default.
• W3135800535 cites W2564988619 @default.
• W3135800535 cites W2762772328 @default.
• W3135800535 cites W2795889789 @default.
• W3135800535 cites W2806453500 @default.
• W3135800535 cites W2960200798 @default.
• W3135800535 cites W2970285019 @default.
• W3135800535 cites W3038503485 @default.
• W3135800535 doi "https://doi.org/10.1016/j.jvssci.2020.11.031" @default.
• W3135800535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8489247" @default.
• W3135800535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34617056" @default.
• W3135800535 hasPublicationYear "2021" @default.
• W3135800535 type Work @default.
• W3135800535 sameAs 3135800535 @default.
• W3135800535 citedByCount "8" @default.
• W3135800535 countsByYear W31358005352022 @default.
• W3135800535 countsByYear W31358005352023 @default.
• W3135800535 crossrefType "journal-article" @default.
• W3135800535 hasAuthorship W3135800535A5004241415 @default.
• W3135800535 hasAuthorship W3135800535A5009935207 @default.
• W3135800535 hasAuthorship W3135800535A5021388716 @default.
• W3135800535 hasAuthorship W3135800535A5029419578 @default.
• W3135800535 hasAuthorship W3135800535A5039036487 @default.
• W3135800535 hasAuthorship W3135800535A5047772842 @default.
• W3135800535 hasAuthorship W3135800535A5054836912 @default.
• W3135800535 hasAuthorship W3135800535A5068493192 @default.
• W3135800535 hasAuthorship W3135800535A5071794395 @default.
• W3135800535 hasBestOaLocation W31358005351 @default.
• W3135800535 hasConcept C120770815 @default.
• W3135800535 hasConcept C126322002 @default.
• W3135800535 hasConcept C134018914 @default.
• W3135800535 hasConcept C1918360 @default.
• W3135800535 hasConcept C2778163477 @default.
• W3135800535 hasConcept C2779134260 @default.
• W3135800535 hasConcept C2780323712 @default.
• W3135800535 hasConcept C2908929049 @default.
• W3135800535 hasConcept C555293320 @default.
• W3135800535 hasConcept C57089818 @default.
• W3135800535 hasConcept C62746215 @default.
• W3135800535 hasConcept C71924100 @default.
• W3135800535 hasConcept C84393581 @default.
• W3135800535 hasConcept C98274493 @default.
• W3135800535 hasConceptScore W3135800535C120770815 @default.
• W3135800535 hasConceptScore W3135800535C126322002 @default.
• W3135800535 hasConceptScore W3135800535C134018914 @default.
• W3135800535 hasConceptScore W3135800535C1918360 @default.
• W3135800535 hasConceptScore W3135800535C2778163477 @default.
• W3135800535 hasConceptScore W3135800535C2779134260 @default.
• W3135800535 hasConceptScore W3135800535C2780323712 @default.
• W3135800535 hasConceptScore W3135800535C2908929049 @default.
• W3135800535 hasConceptScore W3135800535C555293320 @default.
• W3135800535 hasConceptScore W3135800535C57089818 @default.
• W3135800535 hasConceptScore W3135800535C62746215 @default.
• W3135800535 hasConceptScore W3135800535C71924100 @default.
• W3135800535 hasConceptScore W3135800535C84393581 @default.
• W3135800535 hasConceptScore W3135800535C98274493 @default.
• W3135800535 hasFunder F4320322169 @default.
• W3135800535 hasFunder F4320322581 @default.
• W3135800535 hasFunder F4320323656 @default.

• next