FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135800657> ?p ?o ?g. }

• W3135800657 endingPage "241" @default.
• W3135800657 startingPage "221" @default.
• W3135800657 abstract "BACKGROUND: Heterogenous outcome reporting in non-muscle-invasive bladder cancer (NMIBC) effectiveness trials of adjuvant treatment after transurethral resection (TURBT) has been noted in systematic reviews (SRs). This hinders comparing results across trials, combining them in meta-analyses, and evidence-based decision-making for patients and clinicians. OBJECTIVE: We aimed to systematically review the extent of reporting and definition heterogeneity. METHODS: We included randomized controlled trials (RCTs) identified from SRs comparing adjuvant treatments after TURBT or TURBT alone in patients with NMIBC (with or without carcinoma in situ) published between 2000–2020. Abstracts and full texts were screened independently by two reviewers. Data were extracted by one reviewer and checked by another. RESULTS: We screened 807 abstracts; from 15 SRs, 57 RCTs were included. Verbatim outcome names were coded to standard outcome names and organised using the Williamson and Clarke taxonomy. Recurrence (98%), progression (74%), treatment response (in CIS studies) (40%), and adverse events (77%) were frequently reported across studies. However, overall (33%) and cancer-specific (33%) survival, treatment completion (17%) and treatment change (37%) were less often reported. Quality of Life (3%) and economic outcomes (2%) were rarely reported. Heterogeneity was evident throughout, particularly in the definitions of progression and recurrence, and how CIS patients were handled in the analysis of studies with predominantly papillary patients, highlighting further issues with the definition of recurrence and progression vs treatment response for CIS patients. Data reporting was also inconsistent, with some trials reporting event rates at various time-points and others reporting time-to-event with or without Hazard Ratios. Adverse events were inconsistently reported. QoL data was absent in most trials. CONCLUSIONS: Heterogenous outcome reporting is evident in NMIBC effectiveness trials. This has profound implications for meta-analyses, SRs and evidence-based treatment decisions. A core outcome set is required to reduce heterogeneity. PATIENT SUMMARY: This systematic review found inconsistencies in outcome definitions and reporting, pointing out the urgent need for a core outcome set to help improve evidence-based treatment decisions." @default.
• W3135800657 created "2021-03-15" @default.
• W3135800657 creator A5003951535 @default.
• W3135800657 creator A5004584899 @default.
• W3135800657 creator A5016227054 @default.
• W3135800657 creator A5022322719 @default.
• W3135800657 creator A5030962499 @default.
• W3135800657 creator A5039047936 @default.
• W3135800657 creator A5046942511 @default.
• W3135800657 creator A5050157873 @default.
• W3135800657 creator A5050900637 @default.
• W3135800657 creator A5052809243 @default.
• W3135800657 creator A5068797509 @default.
• W3135800657 creator A5077678731 @default.
• W3135800657 creator A5085935947 @default.
• W3135800657 creator A5091703484 @default.
• W3135800657 date "2021-05-25" @default.
• W3135800657 modified "2023-10-14" @default.
• W3135800657 title "A Systematic Review of Outcome Reporting, Definition and Measurement Heterogeneity in Non-Muscle Invasive Bladder Cancer Effectiveness Trials of Adjuvant, Prophylactic Treatment After Transurethral Resection" @default.
• W3135800657 cites W1572827793 @default.
• W3135800657 cites W1684738998 @default.
• W3135800657 cites W172279490 @default.
• W3135800657 cites W1754265771 @default.
• W3135800657 cites W1768837071 @default.
• W3135800657 cites W1912816158 @default.
• W3135800657 cites W1973345646 @default.
• W3135800657 cites W1981266090 @default.
• W3135800657 cites W2053155246 @default.
• W3135800657 cites W2094459583 @default.
• W3135800657 cites W2099325295 @default.
• W3135800657 cites W2104881646 @default.
• W3135800657 cites W2110973315 @default.
• W3135800657 cites W2123981884 @default.
• W3135800657 cites W2133413668 @default.
• W3135800657 cites W2136012690 @default.
• W3135800657 cites W2146391374 @default.
• W3135800657 cites W2152455106 @default.
• W3135800657 cites W2157427387 @default.
• W3135800657 cites W2233134160 @default.
• W3135800657 cites W2270022169 @default.
• W3135800657 cites W2291779308 @default.
• W3135800657 cites W2328393094 @default.
• W3135800657 cites W2519102334 @default.
• W3135800657 cites W2589348657 @default.
• W3135800657 cites W2612425293 @default.
• W3135800657 cites W2683672249 @default.
• W3135800657 cites W2761759076 @default.
• W3135800657 cites W2778471389 @default.
• W3135800657 cites W2800146731 @default.
• W3135800657 cites W2901315920 @default.
• W3135800657 cites W2969983122 @default.
• W3135800657 cites W2983476233 @default.
• W3135800657 cites W2994733409 @default.
• W3135800657 cites W4245346161 @default.
• W3135800657 cites W4249522930 @default.
• W3135800657 cites W4253567199 @default.
• W3135800657 cites W4294215472 @default.
• W3135800657 doi "https://doi.org/10.3233/blc-201510" @default.
• W3135800657 hasPublicationYear "2021" @default.
• W3135800657 type Work @default.
• W3135800657 sameAs 3135800657 @default.
• W3135800657 citedByCount "3" @default.
• W3135800657 countsByYear W31358006572022 @default.
• W3135800657 countsByYear W31358006572023 @default.
• W3135800657 crossrefType "journal-article" @default.
• W3135800657 hasAuthorship W3135800657A5003951535 @default.
• W3135800657 hasAuthorship W3135800657A5004584899 @default.
• W3135800657 hasAuthorship W3135800657A5016227054 @default.
• W3135800657 hasAuthorship W3135800657A5022322719 @default.
• W3135800657 hasAuthorship W3135800657A5030962499 @default.
• W3135800657 hasAuthorship W3135800657A5039047936 @default.
• W3135800657 hasAuthorship W3135800657A5046942511 @default.
• W3135800657 hasAuthorship W3135800657A5050157873 @default.
• W3135800657 hasAuthorship W3135800657A5050900637 @default.
• W3135800657 hasAuthorship W3135800657A5052809243 @default.
• W3135800657 hasAuthorship W3135800657A5068797509 @default.
• W3135800657 hasAuthorship W3135800657A5077678731 @default.
• W3135800657 hasAuthorship W3135800657A5085935947 @default.
• W3135800657 hasAuthorship W3135800657A5091703484 @default.
• W3135800657 hasBestOaLocation W31358006571 @default.
• W3135800657 hasConcept C121608353 @default.
• W3135800657 hasConcept C126322002 @default.
• W3135800657 hasConcept C141071460 @default.
• W3135800657 hasConcept C143998085 @default.
• W3135800657 hasConcept C168563851 @default.
• W3135800657 hasConcept C17744445 @default.
• W3135800657 hasConcept C189708586 @default.
• W3135800657 hasConcept C197934379 @default.
• W3135800657 hasConcept C199539241 @default.
• W3135800657 hasConcept C2777661416 @default.
• W3135800657 hasConcept C2777863537 @default.
• W3135800657 hasConcept C2779473830 @default.
• W3135800657 hasConcept C2780352672 @default.
• W3135800657 hasConcept C535046627 @default.
• W3135800657 hasConcept C71924100 @default.
• W3135800657 hasConcept C95190672 @default.
• W3135800657 hasConceptScore W3135800657C121608353 @default.
• W3135800657 hasConceptScore W3135800657C126322002 @default.

• next