Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135810454> ?p ?o ?g. }
- W3135810454 endingPage "620" @default.
- W3135810454 startingPage "608" @default.
- W3135810454 abstract "Abstract Individuals with a schizophrenia-spectrum disorder (SSD) and those at familial high risk (FHR) for SSDs experience social difficulties that are related to neural abnormalities in the network of brain regions recruited during theory of mind (ToM). Prior work with these groups has focused almost exclusively on characterizing the involvement of these regions in ToM. Here, we examine the representational content of these regions using multivariate pattern analysis. We analyzed two previously collected datasets of SSD, FHR and control participants who, while undergoing functional magnetic resonance imaging, completed the false-belief task in which they read stories describing beliefs or physical representations (e.g. photographs). Univariate and multivariate analyses were performed in regions of interest to evaluate group differences in task-based activation and representational content, respectively. Compared to non-SSDs, SSDs showed reduced decoding accuracy for the category of mental states in the right temporo-parietal junction—which was related to false-belief accuracy—and the dorsal medial prefrontal cortex (DMPFC) and reduced involvement of DMPFC for mental state understanding. FHR showed no differences in decoding accuracy or involvement compared to non-FHR. Given prior studies of disrupted neural involvement in FHR and the lack of decoding differences observed here, the onset of illness may involve processes that corrupt how mental state information is represented." @default.
- W3135810454 created "2021-03-15" @default.
- W3135810454 creator A5009590307 @default.
- W3135810454 creator A5010787350 @default.
- W3135810454 creator A5029563630 @default.
- W3135810454 creator A5073259162 @default.
- W3135810454 date "2021-03-04" @default.
- W3135810454 modified "2023-10-16" @default.
- W3135810454 title "The representation of mental state information in schizophrenia and first-degree relatives: a multivariate pattern analysis of fMRI data" @default.
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