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• W3135817634 abstract "• Lack of comprehensive gene-centric ncRNA database for non-coding variant scrutiny. • The GeneCaRNA database is an all-inclusive compendium of non-coding RNA genes. • GeneCaRNA provides an effective search leveraging annotations from 178 data sources. • GeneCaRNA data are visualized by a UCSC hub and empower ncRNA interaction networks. • GeneCaRNA provides a potent whole genome sequencing disease interpretation tool. Non-coding RNA (ncRNA) genes assume increasing biological importance, with growing associations with diseases. Many ncRNA sources are transcript-centric, but for non-coding variant analysis and disease decipherment it is essential to transform this information into a comprehensive set of genome-mapped ncRNA genes. We present GeneCaRNA, a new all-inclusive gene-centric ncRNA database within the GeneCards Suite. GeneCaRNA information is integrated from four community-backed data structures: the major transcript database RNAcentral with its 20 encompassed databases, and the ncRNA entries of three major gene resources HGNC, Ensembl and NCBI Gene. GeneCaRNA presents 219,587 ncRNA gene pages, a 7-fold increase from those available in our three gene mining sources. Each ncRNA gene has wide-ranging annotation, mined from >100 worldwide sources, providing a powerful GeneCards-leveraged search. The latter empowers VarElect, our disease-gene interpretation tool, allowing one to systematically decipher ncRNA variants. The combined power of GeneCaRNA with GeneHancer, our regulatory elements database, facilitates wide-ranging scrutiny of the non-coding terra incognita of gene networks and whole genome analyses." @default.
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• W3135817634 date "2021-05-01" @default.
• W3135817634 modified "2023-10-13" @default.
• W3135817634 title "GeneCaRNA: A Comprehensive Gene-centric Database of Human Non-coding RNAs in the GeneCards Suite" @default.
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• W3135817634 doi "https://doi.org/10.1016/j.jmb.2021.166913" @default.
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