Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135834627> ?p ?o ?g. }
- W3135834627 endingPage "1489" @default.
- W3135834627 startingPage "1479" @default.
- W3135834627 abstract "Background: The PRESENILIN genes (PSEN1, PSEN2) encoding for their respective proteins have critical roles in many aspects of Alzheimer’s disease (AD) pathogenesis. The PS2V transcript of PSEN2 encodes a truncated protein and is upregulated in AD brains; however, its relevance to AD and disease progression remains to be determined. Objective: Assess transcript levels in postmortem AD and non-AD brain tissue and in lymphocytes collected under the Australian Imaging Biomarker and Lifestyle (AIBL) study. Methods: Full length PSEN2 and PS2V transcript levels were assessed by quantitative digital PCR in postmortem brain tissue (frontal cortex and hippocampus) from control, AD, frontotemporal dementia (FTD), and Lewy body dementia (LBD). Transcript levels were also assessed in lymphocytes obtained from the Perth subset of the AIBL study (n = 160). Linear regression analysis was used to assess correlations between transcript copy number and brain volume and neocortical amyloid load. Results: PS2V levels increased in AD postmortem brain but PS2V was also present at significant levels in FTD and LBD brains. PS2V transcript was detected in lymphocytes and PS2V/PSEN2 ratios were increased in mild cognitive impairment (p = 0.024) and AD (p = 0.019) groups compared to control group. Increased ratios were significantly correlated with hippocampal volumes only (n = 62, β= –0.269, p = 0.03). Conclusion: Taken together, these results suggest that PS2V may be a marker of overall neurodegeneration." @default.
- W3135834627 created "2021-03-15" @default.
- W3135834627 creator A5012850522 @default.
- W3135834627 creator A5019439819 @default.
- W3135834627 creator A5024122155 @default.
- W3135834627 creator A5025669672 @default.
- W3135834627 creator A5038007841 @default.
- W3135834627 creator A5047385288 @default.
- W3135834627 creator A5050793356 @default.
- W3135834627 creator A5058052951 @default.
- W3135834627 creator A5081145118 @default.
- W3135834627 creator A5083750738 @default.
- W3135834627 creator A5084206283 @default.
- W3135834627 creator A5084762480 @default.
- W3135834627 creator A5087249179 @default.
- W3135834627 creator A5089156780 @default.
- W3135834627 creator A5090546674 @default.
- W3135834627 creator A5091505670 @default.
- W3135834627 date "2021-04-20" @default.
- W3135834627 modified "2023-10-16" @default.
- W3135834627 title "Relevance of a Truncated PRESENILIN 2 Transcript to Alzheimer’s Disease and Neurodegeneration" @default.
- W3135834627 cites W1501923207 @default.
- W3135834627 cites W1519424750 @default.
- W3135834627 cites W157704161 @default.
- W3135834627 cites W1964865736 @default.
- W3135834627 cites W1969542268 @default.
- W3135834627 cites W1972214015 @default.
- W3135834627 cites W1981686145 @default.
- W3135834627 cites W1984504747 @default.
- W3135834627 cites W1985816664 @default.
- W3135834627 cites W2003490769 @default.
- W3135834627 cites W2005584197 @default.
- W3135834627 cites W2010625082 @default.
- W3135834627 cites W2013778007 @default.
- W3135834627 cites W2014566892 @default.
- W3135834627 cites W2034311985 @default.
- W3135834627 cites W2042847066 @default.
- W3135834627 cites W2044882968 @default.
- W3135834627 cites W2055776806 @default.
- W3135834627 cites W2066318746 @default.
- W3135834627 cites W2074427084 @default.
- W3135834627 cites W2093403490 @default.
- W3135834627 cites W2103225182 @default.
- W3135834627 cites W2113518834 @default.
- W3135834627 cites W2115799070 @default.
- W3135834627 cites W2122251410 @default.
- W3135834627 cites W2128129890 @default.
- W3135834627 cites W2129771097 @default.
- W3135834627 cites W2134711807 @default.
- W3135834627 cites W2139930052 @default.
- W3135834627 cites W2140361138 @default.
- W3135834627 cites W2144859756 @default.
- W3135834627 cites W2153251699 @default.
- W3135834627 cites W2338681263 @default.
- W3135834627 cites W2787666045 @default.
- W3135834627 cites W2794050431 @default.
- W3135834627 cites W2900370721 @default.
- W3135834627 cites W2921042471 @default.
- W3135834627 cites W4256117201 @default.
- W3135834627 doi "https://doi.org/10.3233/jad-201133" @default.
- W3135834627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33720885" @default.
- W3135834627 hasPublicationYear "2021" @default.
- W3135834627 type Work @default.
- W3135834627 sameAs 3135834627 @default.
- W3135834627 citedByCount "3" @default.
- W3135834627 countsByYear W31358346272022 @default.
- W3135834627 countsByYear W31358346272023 @default.
- W3135834627 crossrefType "journal-article" @default.
- W3135834627 hasAuthorship W3135834627A5012850522 @default.
- W3135834627 hasAuthorship W3135834627A5019439819 @default.
- W3135834627 hasAuthorship W3135834627A5024122155 @default.
- W3135834627 hasAuthorship W3135834627A5025669672 @default.
- W3135834627 hasAuthorship W3135834627A5038007841 @default.
- W3135834627 hasAuthorship W3135834627A5047385288 @default.
- W3135834627 hasAuthorship W3135834627A5050793356 @default.
- W3135834627 hasAuthorship W3135834627A5058052951 @default.
- W3135834627 hasAuthorship W3135834627A5081145118 @default.
- W3135834627 hasAuthorship W3135834627A5083750738 @default.
- W3135834627 hasAuthorship W3135834627A5084206283 @default.
- W3135834627 hasAuthorship W3135834627A5084762480 @default.
- W3135834627 hasAuthorship W3135834627A5087249179 @default.
- W3135834627 hasAuthorship W3135834627A5089156780 @default.
- W3135834627 hasAuthorship W3135834627A5090546674 @default.
- W3135834627 hasAuthorship W3135834627A5091505670 @default.
- W3135834627 hasConcept C142724271 @default.
- W3135834627 hasConcept C148762608 @default.
- W3135834627 hasConcept C169760540 @default.
- W3135834627 hasConcept C175344181 @default.
- W3135834627 hasConcept C2776485563 @default.
- W3135834627 hasConcept C2776925932 @default.
- W3135834627 hasConcept C2778641062 @default.
- W3135834627 hasConcept C2779134260 @default.
- W3135834627 hasConcept C2779483572 @default.
- W3135834627 hasConcept C2781161787 @default.
- W3135834627 hasConcept C2781197716 @default.
- W3135834627 hasConcept C502032728 @default.
- W3135834627 hasConcept C54355233 @default.
- W3135834627 hasConcept C71924100 @default.