FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135837265> ?p ?o ?g. }

• W3135837265 abstract "Abstract Schizophrenia (SCZ) is an etiologically heterogeneous disease with genetic and environmental risk factors (e.g., Toxoplasma gondii infection) differing among affected individuals. Distinguishing such risk factors may point to differences in pathophysiological pathways and facilitate the discovery of individualized treatments. Toxoplasma gondii (TOXO) has been implicated in increasing the risk of schizophrenia. To determine whether TOXO-positive individuals with SCZ have a different polygenic risk burden than uninfected people, we applied the SCZ polygenic risk score (SCZ-PRS) derived from the Psychiatric GWAS Consortium separately to the TOXO-positive and TOXO-negative subjects with the diagnosis of SCZ as the outcome variable. The SCZ-PRS does not include variants in the major histocompatibility complex. Of 790 subjects assessed for TOXO, the 662 TOXO-negative subjects (50.8% with SCZ) reached a Bonferroni corrected significant association (p = 0.00017, R2 = 0.023). In contrast, the 128 TOXO-positive individuals (53.1% with SCZ) showed no significant association (p = 0.354) for SCZ-PRS and had a much lower R2 (R2 = 0.007). To account for Type-2 error in the TOXO-positive dataset, we performed a random sampling of the TOXO-negative subpopulation (n = 130, repeated 100 times) to simulate equivalent power between groups: the p-value was  0.354. We found intriguing evidence that the SCZ-PRS predicts SCZ in TOXO-negative subjects, as expected, but not in the TOXO-positive individuals. This result highlights the importance of considering environmental risk factors to distinguish a subgroup with independent or different genetic components involved in the development of SCZ." @default.
• W3135837265 created "2021-03-15" @default.
• W3135837265 creator A5012366081 @default.
• W3135837265 creator A5016572077 @default.
• W3135837265 creator A5017691789 @default.
• W3135837265 creator A5018916325 @default.
• W3135837265 creator A5023825201 @default.
• W3135837265 creator A5025251150 @default.
• W3135837265 creator A5032828460 @default.
• W3135837265 creator A5052748790 @default.
• W3135837265 creator A5057974062 @default.
• W3135837265 creator A5064423443 @default.
• W3135837265 creator A5067541594 @default.
• W3135837265 creator A5083258080 @default.
• W3135837265 date "2021-05-01" @default.
• W3135837265 modified "2023-09-24" @default.
• W3135837265 title "Polygenic risk scores differentiate schizophrenia patients with toxoplasma gondii compared to toxoplasma seronegative patients" @default.
• W3135837265 cites W1968703969 @default.
• W3135837265 cites W1982763490 @default.
• W3135837265 cites W1997338841 @default.
• W3135837265 cites W2003756728 @default.
• W3135837265 cites W2004248532 @default.
• W3135837265 cites W2014517913 @default.
• W3135837265 cites W2027308346 @default.
• W3135837265 cites W2037238692 @default.
• W3135837265 cites W2076010384 @default.
• W3135837265 cites W2101357408 @default.
• W3135837265 cites W2110048796 @default.
• W3135837265 cites W2120827529 @default.
• W3135837265 cites W2121505354 @default.
• W3135837265 cites W2161633633 @default.
• W3135837265 cites W2499952289 @default.
• W3135837265 cites W2513402838 @default.
• W3135837265 cites W2560355764 @default.
• W3135837265 cites W2777388159 @default.
• W3135837265 cites W2790789435 @default.
• W3135837265 cites W2803229193 @default.
• W3135837265 cites W2807303223 @default.
• W3135837265 cites W2907428708 @default.
• W3135837265 cites W2944746345 @default.
• W3135837265 cites W2999495681 @default.
• W3135837265 doi "https://doi.org/10.1016/j.comppsych.2021.152236" @default.
• W3135837265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33721583" @default.
• W3135837265 hasPublicationYear "2021" @default.
• W3135837265 type Work @default.
• W3135837265 sameAs 3135837265 @default.
• W3135837265 citedByCount "4" @default.
• W3135837265 countsByYear W31358372652021 @default.
• W3135837265 countsByYear W31358372652022 @default.
• W3135837265 crossrefType "journal-article" @default.
• W3135837265 hasAuthorship W3135837265A5012366081 @default.
• W3135837265 hasAuthorship W3135837265A5016572077 @default.
• W3135837265 hasAuthorship W3135837265A5017691789 @default.
• W3135837265 hasAuthorship W3135837265A5018916325 @default.
• W3135837265 hasAuthorship W3135837265A5023825201 @default.
• W3135837265 hasAuthorship W3135837265A5025251150 @default.
• W3135837265 hasAuthorship W3135837265A5032828460 @default.
• W3135837265 hasAuthorship W3135837265A5052748790 @default.
• W3135837265 hasAuthorship W3135837265A5057974062 @default.
• W3135837265 hasAuthorship W3135837265A5064423443 @default.
• W3135837265 hasAuthorship W3135837265A5067541594 @default.
• W3135837265 hasAuthorship W3135837265A5083258080 @default.
• W3135837265 hasBestOaLocation W31358372651 @default.
• W3135837265 hasConcept C104317684 @default.
• W3135837265 hasConcept C105795698 @default.
• W3135837265 hasConcept C118552586 @default.
• W3135837265 hasConcept C126322002 @default.
• W3135837265 hasConcept C127808970 @default.
• W3135837265 hasConcept C135763542 @default.
• W3135837265 hasConcept C153209595 @default.
• W3135837265 hasConcept C15744967 @default.
• W3135837265 hasConcept C159654299 @default.
• W3135837265 hasConcept C203014093 @default.
• W3135837265 hasConcept C2776412080 @default.
• W3135837265 hasConcept C2778128430 @default.
• W3135837265 hasConcept C2993137441 @default.
• W3135837265 hasConcept C33923547 @default.
• W3135837265 hasConcept C54355233 @default.
• W3135837265 hasConcept C71924100 @default.
• W3135837265 hasConcept C86803240 @default.
• W3135837265 hasConceptScore W3135837265C104317684 @default.
• W3135837265 hasConceptScore W3135837265C105795698 @default.
• W3135837265 hasConceptScore W3135837265C118552586 @default.
• W3135837265 hasConceptScore W3135837265C126322002 @default.
• W3135837265 hasConceptScore W3135837265C127808970 @default.
• W3135837265 hasConceptScore W3135837265C135763542 @default.
• W3135837265 hasConceptScore W3135837265C153209595 @default.
• W3135837265 hasConceptScore W3135837265C15744967 @default.
• W3135837265 hasConceptScore W3135837265C159654299 @default.
• W3135837265 hasConceptScore W3135837265C203014093 @default.
• W3135837265 hasConceptScore W3135837265C2776412080 @default.
• W3135837265 hasConceptScore W3135837265C2778128430 @default.
• W3135837265 hasConceptScore W3135837265C2993137441 @default.
• W3135837265 hasConceptScore W3135837265C33923547 @default.
• W3135837265 hasConceptScore W3135837265C54355233 @default.
• W3135837265 hasConceptScore W3135837265C71924100 @default.
• W3135837265 hasConceptScore W3135837265C86803240 @default.
• W3135837265 hasFunder F4320306147 @default.
• W3135837265 hasFunder F4320332161 @default.
• W3135837265 hasFunder F4320332180 @default.

• next