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- W3135842739 abstract "3,4-Diacyl-2-quinolone derivatives were prepared in a rapid manner starting from N-(2’-alkynylaryl)-1,3-ketoamide substrates. The reaction showcased a mild radical process mediated by ceric ammonium nitrate (CAN) in the presence of 5 mol% PdCl2 under basic conditions and was applicable to a wide range of substrates, giving 3,4-diacyl-2-quinolone products in up to 91% yield in over 40 examples. The reaction proceeded via the generation of a radical intermediate which could be trapped as a TEMPO-adduct that was isolated and fully characterized. The reported method provided a practical and scalable synthetic access to densely functionalized 3,4-diacyl-2-quinolone derivatives which would be suitable for further applications including medicinal and bioactivity evaluations as well as synthetic transformations." @default.
- W3135842739 created "2021-03-15" @default.
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- W3135842739 date "2021-03-23" @default.
- W3135842739 modified "2023-10-16" @default.
- W3135842739 title "PdCl <sub>2</sub> ‐Catalyzed Oxidative Cyclization of <i>N</i> ‐(2’‐Alkynylaryl)‐1,3‐ketoamides: Synthesis of 3,4‐Diacyl‐2‐Quinolones" @default.
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- W3135842739 doi "https://doi.org/10.1002/ajoc.202100035" @default.
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