Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135847349> ?p ?o ?g. }
- W3135847349 endingPage "847" @default.
- W3135847349 startingPage "834" @default.
- W3135847349 abstract "Triterpenoids are ubiquitously distributed secondary metabolites, primarily scrutinized as a source of medication and preventive measures for various chronic diseases. The ease of isolation and excellent pharmacological properties of triterpenoids are notable reasons behind the exponential rise of extensive research on the bioactive triterpenoids over the past few decades. Herein, we attempted to explore the anticancer potential of the fruit extract of the ethnomedicinal plant Dillenia indica against oral squamous cell carcinoma (OSCC) and have exclusively attributed the efficacy of the extracts to the presence of two triterpenoids, namely, betulinic acid (BA) and koetjapic acid (KA). Preliminary in vitro screening of both BA and KA unveiled that the entities could impart cytotoxicity and induce apoptosis in OSCC cell lines, which were further well-supported by virtual screening based on ligand binding affinity and molecular dynamic simulations. Additionally, the aforementioned metabolites could significantly modulate the critical players such as Akt/mTOR, NF-κB, and JAK/STAT3 signaling pathways involved in the regulation of important hallmarks of cancer like cell survival, proliferation, invasion, angiogenesis, and metastasis. The present findings provide insight and immense scientific support and integrity to a piece of indigenous knowledge. However, in vivo validation is a requisite for moving to clinical trials and developing it as a commercial drug." @default.
- W3135847349 created "2021-03-15" @default.
- W3135847349 creator A5006044322 @default.
- W3135847349 creator A5006114608 @default.
- W3135847349 creator A5019088155 @default.
- W3135847349 creator A5034161818 @default.
- W3135847349 creator A5037680581 @default.
- W3135847349 creator A5038274221 @default.
- W3135847349 creator A5038694282 @default.
- W3135847349 creator A5044329274 @default.
- W3135847349 creator A5060091493 @default.
- W3135847349 creator A5090030629 @default.
- W3135847349 date "2021-03-09" @default.
- W3135847349 modified "2023-09-26" @default.
- W3135847349 title "Exploring the Cytotoxic Effects of the Extracts and Bioactive Triterpenoids from <i>Dillenia indica</i> against Oral Squamous Cell Carcinoma: A Scientific Interpretation and Validation of Indigenous Knowledge" @default.
- W3135847349 cites W1438161774 @default.
- W3135847349 cites W1482994876 @default.
- W3135847349 cites W1853943513 @default.
- W3135847349 cites W1977258127 @default.
- W3135847349 cites W2001641583 @default.
- W3135847349 cites W2002212526 @default.
- W3135847349 cites W2006858056 @default.
- W3135847349 cites W2017807973 @default.
- W3135847349 cites W2020902654 @default.
- W3135847349 cites W2024608433 @default.
- W3135847349 cites W2027730833 @default.
- W3135847349 cites W2032173703 @default.
- W3135847349 cites W2056103673 @default.
- W3135847349 cites W2058843107 @default.
- W3135847349 cites W2069977793 @default.
- W3135847349 cites W2073631346 @default.
- W3135847349 cites W2093156396 @default.
- W3135847349 cites W2107826427 @default.
- W3135847349 cites W2109398166 @default.
- W3135847349 cites W2114375386 @default.
- W3135847349 cites W2117692326 @default.
- W3135847349 cites W2137631271 @default.
- W3135847349 cites W2151633680 @default.
- W3135847349 cites W2156656162 @default.
- W3135847349 cites W2161821631 @default.
- W3135847349 cites W2164799898 @default.
- W3135847349 cites W2167289119 @default.
- W3135847349 cites W2173069051 @default.
- W3135847349 cites W2337482838 @default.
- W3135847349 cites W2343214358 @default.
- W3135847349 cites W2417725501 @default.
- W3135847349 cites W2522163200 @default.
- W3135847349 cites W2573794681 @default.
- W3135847349 cites W2774395025 @default.
- W3135847349 cites W2799475117 @default.
- W3135847349 cites W2804699489 @default.
- W3135847349 cites W2805347650 @default.
- W3135847349 cites W2809476276 @default.
- W3135847349 cites W2886600771 @default.
- W3135847349 cites W2886893513 @default.
- W3135847349 cites W2889646458 @default.
- W3135847349 cites W2891011884 @default.
- W3135847349 cites W2901849372 @default.
- W3135847349 cites W2922779982 @default.
- W3135847349 cites W2937947604 @default.
- W3135847349 cites W2938078090 @default.
- W3135847349 cites W2955457942 @default.
- W3135847349 cites W2964976657 @default.
- W3135847349 cites W2969548222 @default.
- W3135847349 cites W2990283230 @default.
- W3135847349 cites W2990924183 @default.
- W3135847349 cites W2999004020 @default.
- W3135847349 cites W3002071625 @default.
- W3135847349 cites W3023523249 @default.
- W3135847349 cites W3025016259 @default.
- W3135847349 cites W3037948381 @default.
- W3135847349 cites W3047776760 @default.
- W3135847349 cites W3082781661 @default.
- W3135847349 cites W3119493932 @default.
- W3135847349 doi "https://doi.org/10.1021/acsptsci.1c00011" @default.
- W3135847349 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8033758" @default.
- W3135847349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33860206" @default.
- W3135847349 hasPublicationYear "2021" @default.
- W3135847349 type Work @default.
- W3135847349 sameAs 3135847349 @default.
- W3135847349 citedByCount "12" @default.
- W3135847349 countsByYear W31358473492021 @default.
- W3135847349 countsByYear W31358473492022 @default.
- W3135847349 countsByYear W31358473492023 @default.
- W3135847349 crossrefType "journal-article" @default.
- W3135847349 hasAuthorship W3135847349A5006044322 @default.
- W3135847349 hasAuthorship W3135847349A5006114608 @default.
- W3135847349 hasAuthorship W3135847349A5019088155 @default.
- W3135847349 hasAuthorship W3135847349A5034161818 @default.
- W3135847349 hasAuthorship W3135847349A5037680581 @default.
- W3135847349 hasAuthorship W3135847349A5038274221 @default.
- W3135847349 hasAuthorship W3135847349A5038694282 @default.
- W3135847349 hasAuthorship W3135847349A5044329274 @default.
- W3135847349 hasAuthorship W3135847349A5060091493 @default.
- W3135847349 hasAuthorship W3135847349A5090030629 @default.
- W3135847349 hasBestOaLocation W31358473492 @default.
- W3135847349 hasConcept C107585567 @default.
- W3135847349 hasConcept C109316439 @default.