Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135851966> ?p ?o ?g. }
- W3135851966 abstract "Abstract Blood malignancies arise from the dysregulation of haematopoiesis. The type of blood cell and the specific order of oncogenic events initiating abnormal growth ultimately determine the cancer subtype and subsequent clinical outcome. HOXA9 plays an important role in acute myeloid leukaemia (AML) prognosis by promoting blood cell expansion and altering differentiation; however, the function of HOXA9 in other blood malignancies is still unclear. Here, we demonstrate the importance of this gene in chronic myeloproliferative neoplasms (MPN) and highlight the biological switch and prognosis marker properties of HOXA9 in AML and MPN. This binary switch function can explain the clinical stratification of these two blood disorders. First, we establish the ability of HOXA9 to stratify AML patients with distinct cellular and clinical outcomes. Then, through the use of a computational network model of MPN, we show that the self-activation of HOXA9 and its relationship to JAK2 and TET2 can explain the branching progression of JAK2/TET2 mutant MPN patients towards divergent clinical characteristics. Finally, we predict a connection between the RUNX1 and MYB genes and a suppressive role for the NOTCH pathway in MPN diseases." @default.
- W3135851966 created "2021-03-15" @default.
- W3135851966 creator A5027490511 @default.
- W3135851966 creator A5064997315 @default.
- W3135851966 creator A5086492427 @default.
- W3135851966 creator A5091801141 @default.
- W3135851966 date "2021-03-06" @default.
- W3135851966 modified "2023-10-03" @default.
- W3135851966 title "HOXA9 acts as a regulatory switch in acute myeloid leukaemia and myeloproliferative neoplasms" @default.
- W3135851966 cites W1255676896 @default.
- W3135851966 cites W1575657391 @default.
- W3135851966 cites W1858399368 @default.
- W3135851966 cites W1993775542 @default.
- W3135851966 cites W2001460493 @default.
- W3135851966 cites W2002784005 @default.
- W3135851966 cites W2036163692 @default.
- W3135851966 cites W2038969189 @default.
- W3135851966 cites W2044511711 @default.
- W3135851966 cites W2047365291 @default.
- W3135851966 cites W2057360098 @default.
- W3135851966 cites W2059194853 @default.
- W3135851966 cites W2061866900 @default.
- W3135851966 cites W2072881492 @default.
- W3135851966 cites W2079360110 @default.
- W3135851966 cites W2097743943 @default.
- W3135851966 cites W2101518963 @default.
- W3135851966 cites W2107139993 @default.
- W3135851966 cites W2109363337 @default.
- W3135851966 cites W2111866362 @default.
- W3135851966 cites W2125367344 @default.
- W3135851966 cites W2130983069 @default.
- W3135851966 cites W2146142395 @default.
- W3135851966 cites W2149185747 @default.
- W3135851966 cites W2406250479 @default.
- W3135851966 cites W2419558864 @default.
- W3135851966 cites W2529435032 @default.
- W3135851966 cites W2555224212 @default.
- W3135851966 cites W2588622147 @default.
- W3135851966 cites W2725261266 @default.
- W3135851966 cites W2773788125 @default.
- W3135851966 cites W2786795173 @default.
- W3135851966 cites W2790425028 @default.
- W3135851966 cites W2793421318 @default.
- W3135851966 cites W2803918343 @default.
- W3135851966 cites W2901714442 @default.
- W3135851966 cites W2929105074 @default.
- W3135851966 cites W2955516635 @default.
- W3135851966 cites W3102476541 @default.
- W3135851966 cites W4245754806 @default.
- W3135851966 cites W4249369999 @default.
- W3135851966 doi "https://doi.org/10.1101/2021.03.05.434116" @default.
- W3135851966 hasPublicationYear "2021" @default.
- W3135851966 type Work @default.
- W3135851966 sameAs 3135851966 @default.
- W3135851966 citedByCount "0" @default.
- W3135851966 crossrefType "posted-content" @default.
- W3135851966 hasAuthorship W3135851966A5027490511 @default.
- W3135851966 hasAuthorship W3135851966A5064997315 @default.
- W3135851966 hasAuthorship W3135851966A5086492427 @default.
- W3135851966 hasAuthorship W3135851966A5091801141 @default.
- W3135851966 hasBestOaLocation W31358519661 @default.
- W3135851966 hasConcept C109159458 @default.
- W3135851966 hasConcept C121608353 @default.
- W3135851966 hasConcept C126322002 @default.
- W3135851966 hasConcept C203014093 @default.
- W3135851966 hasConcept C2778193527 @default.
- W3135851966 hasConcept C2779282312 @default.
- W3135851966 hasConcept C28328180 @default.
- W3135851966 hasConcept C2910274570 @default.
- W3135851966 hasConcept C502942594 @default.
- W3135851966 hasConcept C54355233 @default.
- W3135851966 hasConcept C71924100 @default.
- W3135851966 hasConcept C86803240 @default.
- W3135851966 hasConceptScore W3135851966C109159458 @default.
- W3135851966 hasConceptScore W3135851966C121608353 @default.
- W3135851966 hasConceptScore W3135851966C126322002 @default.
- W3135851966 hasConceptScore W3135851966C203014093 @default.
- W3135851966 hasConceptScore W3135851966C2778193527 @default.
- W3135851966 hasConceptScore W3135851966C2779282312 @default.
- W3135851966 hasConceptScore W3135851966C28328180 @default.
- W3135851966 hasConceptScore W3135851966C2910274570 @default.
- W3135851966 hasConceptScore W3135851966C502942594 @default.
- W3135851966 hasConceptScore W3135851966C54355233 @default.
- W3135851966 hasConceptScore W3135851966C71924100 @default.
- W3135851966 hasConceptScore W3135851966C86803240 @default.
- W3135851966 hasLocation W31358519661 @default.
- W3135851966 hasOpenAccess W3135851966 @default.
- W3135851966 hasPrimaryLocation W31358519661 @default.
- W3135851966 hasRelatedWork W1590498065 @default.
- W3135851966 hasRelatedWork W2081031511 @default.
- W3135851966 hasRelatedWork W2156722529 @default.
- W3135851966 hasRelatedWork W2160494819 @default.
- W3135851966 hasRelatedWork W2337320742 @default.
- W3135851966 hasRelatedWork W3018598466 @default.
- W3135851966 hasRelatedWork W3020355793 @default.
- W3135851966 hasRelatedWork W4225145976 @default.
- W3135851966 hasRelatedWork W4235442288 @default.
- W3135851966 hasRelatedWork W4318624625 @default.
- W3135851966 isParatext "false" @default.
- W3135851966 isRetracted "false" @default.