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- W3135853802 endingPage "L1193" @default.
- W3135853802 startingPage "L1186" @default.
- W3135853802 abstract "A significant number of patients with coronavirus disease 2019 (COVID-19) develop acute respiratory distress syndrome (ARDS) that is associated with a poor outcome. The molecular mechanisms driving failure of the alveolar barrier upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain incompletely understood. The Na,K-ATPase is an adhesion molecule and a plasma membrane transporter that is critically required for proper alveolar epithelial function by both promoting barrier integrity and resolution of excess alveolar fluid, thus enabling appropriate gas exchange. However, numerous SARS-CoV-2-mediated and COVID-19-related signals directly or indirectly impair the function of the Na,K-ATPase, thereby potentially contributing to disease progression. In this Perspective, we highlight some of the putative mechanisms of SARS-CoV-2-driven dysfunction of the Na,K-ATPase, focusing on expression, maturation, and trafficking of the transporter. A therapeutic mean to selectively inhibit the maladaptive signals that impair the Na,K-ATPase upon SARS-CoV-2 infection might be effective in reestablishing the alveolar epithelial barrier and promoting alveolar fluid clearance and thus advantageous in patients with COVID-19-associated ARDS." @default.
- W3135853802 created "2021-03-15" @default.
- W3135853802 creator A5028749103 @default.
- W3135853802 creator A5060335517 @default.
- W3135853802 date "2021-06-01" @default.
- W3135853802 modified "2023-10-18" @default.
- W3135853802 title "Molecular mechanisms of Na,K-ATPase dysregulation driving alveolar epithelial barrier failure in severe COVID-19" @default.
- W3135853802 cites W1566255459 @default.
- W3135853802 cites W1586371368 @default.
- W3135853802 cites W1969829115 @default.
- W3135853802 cites W1975595673 @default.
- W3135853802 cites W1981703454 @default.
- W3135853802 cites W1985197179 @default.
- W3135853802 cites W1987505763 @default.
- W3135853802 cites W1993413023 @default.
- W3135853802 cites W1993779407 @default.
- W3135853802 cites W2000971263 @default.
- W3135853802 cites W2001930317 @default.
- W3135853802 cites W2008042305 @default.
- W3135853802 cites W2009326075 @default.
- W3135853802 cites W2013996883 @default.
- W3135853802 cites W2016168978 @default.
- W3135853802 cites W2019312368 @default.
- W3135853802 cites W2023397454 @default.
- W3135853802 cites W2028354274 @default.
- W3135853802 cites W2028980230 @default.
- W3135853802 cites W2033777508 @default.
- W3135853802 cites W2040596758 @default.
- W3135853802 cites W2048930760 @default.
- W3135853802 cites W2053349673 @default.
- W3135853802 cites W2081315017 @default.
- W3135853802 cites W2090605131 @default.
- W3135853802 cites W2096549714 @default.
- W3135853802 cites W2104982056 @default.
- W3135853802 cites W2105076167 @default.
- W3135853802 cites W2109618330 @default.
- W3135853802 cites W2110707896 @default.
- W3135853802 cites W2111091988 @default.
- W3135853802 cites W2118995962 @default.
- W3135853802 cites W2132167011 @default.
- W3135853802 cites W2133204871 @default.
- W3135853802 cites W2133449810 @default.
- W3135853802 cites W2136331613 @default.
- W3135853802 cites W2138182041 @default.
- W3135853802 cites W2138790773 @default.
- W3135853802 cites W2141818933 @default.
- W3135853802 cites W2142048790 @default.
- W3135853802 cites W2142130608 @default.
- W3135853802 cites W2145084709 @default.
- W3135853802 cites W2159485385 @default.
- W3135853802 cites W2159567532 @default.
- W3135853802 cites W2164434965 @default.
- W3135853802 cites W2180643154 @default.
- W3135853802 cites W2181668860 @default.
- W3135853802 cites W2188324213 @default.
- W3135853802 cites W2218393282 @default.
- W3135853802 cites W2263003212 @default.
- W3135853802 cites W2263498456 @default.
- W3135853802 cites W2279646527 @default.
- W3135853802 cites W2300945474 @default.
- W3135853802 cites W2303831017 @default.
- W3135853802 cites W2314477558 @default.
- W3135853802 cites W2316699811 @default.
- W3135853802 cites W2415358415 @default.
- W3135853802 cites W2470646526 @default.
- W3135853802 cites W2604264722 @default.
- W3135853802 cites W2618111461 @default.
- W3135853802 cites W2622488119 @default.
- W3135853802 cites W2626031092 @default.
- W3135853802 cites W2805630019 @default.
- W3135853802 cites W2808130319 @default.
- W3135853802 cites W2888979282 @default.
- W3135853802 cites W2897146785 @default.
- W3135853802 cites W2946013240 @default.
- W3135853802 cites W3001118548 @default.
- W3135853802 cites W3008028633 @default.
- W3135853802 cites W3008824018 @default.
- W3135853802 cites W3008827533 @default.
- W3135853802 cites W3011305151 @default.
- W3135853802 cites W3012042245 @default.
- W3135853802 cites W3012923578 @default.
- W3135853802 cites W3016489853 @default.
- W3135853802 cites W3016885766 @default.
- W3135853802 cites W3018037557 @default.
- W3135853802 cites W3023376619 @default.
- W3135853802 cites W3024896020 @default.
- W3135853802 cites W3026002191 @default.
- W3135853802 cites W3026032531 @default.
- W3135853802 cites W3026354710 @default.
- W3135853802 cites W3030700284 @default.
- W3135853802 cites W3030871984 @default.
- W3135853802 cites W3033090821 @default.
- W3135853802 cites W3036360747 @default.
- W3135853802 cites W3043427328 @default.
- W3135853802 cites W3045775815 @default.
- W3135853802 cites W3045822005 @default.
- W3135853802 cites W3046992876 @default.
- W3135853802 cites W3080285565 @default.