FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135853960> ?p ?o ?g. }

• W3135853960 endingPage "434" @default.
• W3135853960 startingPage "424" @default.
• W3135853960 abstract "Objective: This study aimed to identify the novel microRNAs (miRNAs) for early diagnosis of bladder cancer. Materials and Methods: Differentially expressed miRNAs between early and advanced bladder cancer were identified by differential expression analysis, using miRNA-seq data from The Cancer Genome Atlas (TCGA). The optimal subset of feature miRNAs for pathologic stage prediction was acquired by Random Forest algorithm and was used to construct a support vector machine (SVM) classifier. The performance of the SVM classifier in predicting the progression of bladder cancer samples was validated using an independent validating dataset. An miRNA-regulated target gene network was finally constructed and functional annotation were performed for the target genes. Results: A total of 52 significantly differentially expressed miRNAs were identified between early and advanced bladder cancer samples and 17 of these miRNAs were identified to be feature miRNAs. The 17 feature miRNAs were used to construct an SVM classifier, which showed a high performance in pathologic stage prediction for both training and validating dataset. Besides, our functional annotation analysis showed that the feature miRNAs were significantly involved in biological processes and pathways related to extracellular matrix process and PI3K/Akt signaling. Conclusions: The optimal subset of miRNAs may act as potential therapeutic targets and diagnostic markers of bladder cancer." @default.
• W3135853960 created "2021-03-15" @default.
• W3135853960 creator A5017847020 @default.
• W3135853960 creator A5025896370 @default.
• W3135853960 creator A5048868382 @default.
• W3135853960 creator A5055151897 @default.
• W3135853960 creator A5061494199 @default.
• W3135853960 creator A5061608987 @default.
• W3135853960 date "2022-08-01" @default.
• W3135853960 modified "2023-09-26" @default.
• W3135853960 title "Screening of MicroRNA Biomarkers Related to the Progression of Bladder Cancer" @default.
• W3135853960 cites W1855871243 @default.
• W3135853960 cites W1974254202 @default.
• W3135853960 cites W1975304818 @default.
• W3135853960 cites W1989376396 @default.
• W3135853960 cites W2007948724 @default.
• W3135853960 cites W2010926126 @default.
• W3135853960 cites W2020201687 @default.
• W3135853960 cites W2032798840 @default.
• W3135853960 cites W2075744639 @default.
• W3135853960 cites W2088358497 @default.
• W3135853960 cites W2089154518 @default.
• W3135853960 cites W2102570883 @default.
• W3135853960 cites W2111547563 @default.
• W3135853960 cites W2116634113 @default.
• W3135853960 cites W2132566055 @default.
• W3135853960 cites W2133220812 @default.
• W3135853960 cites W2146512944 @default.
• W3135853960 cites W2156332695 @default.
• W3135853960 cites W2159083300 @default.
• W3135853960 cites W2167980479 @default.
• W3135853960 cites W2317125315 @default.
• W3135853960 cites W2394657413 @default.
• W3135853960 cites W2405264636 @default.
• W3135853960 cites W2473193283 @default.
• W3135853960 cites W2507608866 @default.
• W3135853960 cites W2570618306 @default.
• W3135853960 cites W2581012810 @default.
• W3135853960 cites W2614876189 @default.
• W3135853960 cites W2741016737 @default.
• W3135853960 cites W2808614229 @default.
• W3135853960 cites W2952132363 @default.
• W3135853960 cites W2959929684 @default.
• W3135853960 cites W2962725324 @default.
• W3135853960 cites W2963091977 @default.
• W3135853960 cites W2982302765 @default.
• W3135853960 cites W2983674450 @default.
• W3135853960 cites W4294214970 @default.
• W3135853960 cites W918937935 @default.
• W3135853960 doi "https://doi.org/10.1089/cbr.2020.4217" @default.
• W3135853960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33661056" @default.
• W3135853960 hasPublicationYear "2022" @default.
• W3135853960 type Work @default.
• W3135853960 sameAs 3135853960 @default.
• W3135853960 citedByCount "1" @default.
• W3135853960 countsByYear W31358539602021 @default.
• W3135853960 crossrefType "journal-article" @default.
• W3135853960 hasAuthorship W3135853960A5017847020 @default.
• W3135853960 hasAuthorship W3135853960A5025896370 @default.
• W3135853960 hasAuthorship W3135853960A5048868382 @default.
• W3135853960 hasAuthorship W3135853960A5055151897 @default.
• W3135853960 hasAuthorship W3135853960A5061494199 @default.
• W3135853960 hasAuthorship W3135853960A5061608987 @default.
• W3135853960 hasConcept C104317684 @default.
• W3135853960 hasConcept C121608353 @default.
• W3135853960 hasConcept C12267149 @default.
• W3135853960 hasConcept C145059251 @default.
• W3135853960 hasConcept C154945302 @default.
• W3135853960 hasConcept C169258074 @default.
• W3135853960 hasConcept C2780352672 @default.
• W3135853960 hasConcept C41008148 @default.
• W3135853960 hasConcept C54355233 @default.
• W3135853960 hasConcept C60644358 @default.
• W3135853960 hasConcept C70721500 @default.
• W3135853960 hasConcept C86803240 @default.
• W3135853960 hasConcept C95623464 @default.
• W3135853960 hasConceptScore W3135853960C104317684 @default.
• W3135853960 hasConceptScore W3135853960C121608353 @default.
• W3135853960 hasConceptScore W3135853960C12267149 @default.
• W3135853960 hasConceptScore W3135853960C145059251 @default.
• W3135853960 hasConceptScore W3135853960C154945302 @default.
• W3135853960 hasConceptScore W3135853960C169258074 @default.
• W3135853960 hasConceptScore W3135853960C2780352672 @default.
• W3135853960 hasConceptScore W3135853960C41008148 @default.
• W3135853960 hasConceptScore W3135853960C54355233 @default.
• W3135853960 hasConceptScore W3135853960C60644358 @default.
• W3135853960 hasConceptScore W3135853960C70721500 @default.
• W3135853960 hasConceptScore W3135853960C86803240 @default.
• W3135853960 hasConceptScore W3135853960C95623464 @default.
• W3135853960 hasIssue "6" @default.
• W3135853960 hasLocation W31358539601 @default.
• W3135853960 hasLocation W31358539602 @default.
• W3135853960 hasOpenAccess W3135853960 @default.
• W3135853960 hasPrimaryLocation W31358539601 @default.
• W3135853960 hasRelatedWork W1996856743 @default.
• W3135853960 hasRelatedWork W2938230790 @default.
• W3135853960 hasRelatedWork W3127571946 @default.
• W3135853960 hasRelatedWork W3168994312 @default.

• next