Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135859770> ?p ?o ?g. }
- W3135859770 endingPage "e10830" @default.
- W3135859770 startingPage "e10830" @default.
- W3135859770 abstract "Tumor-derived circulating tumor DNA (ctDNA) has demonstrated its excellent potential for cancer diagnosis by DNA methylome; therefore, this study aimed to identify the retinoblastoma (RB) specific methylated CpG loci as the RB diagnostic biomarkers and design a methylation specific assay to detect these biomarker from aqueous humor of RB patients. Through a genome-wide methylation profiling of tissue samples from patients with RB, normal retina and other retinal diseases, we shortlisted two CpG loci were only methylated in RB but not in normal retina or other retinal diseases. Both of these two CpG loci were located in the genome of TFAP2A. Through the screening, a primer and probe set for the two CpG loci were tested in fully methylated standards and RB tissues with a significant differentiation of RB. Our results of this assay tested in aqueous humor from RB revealed an accuracy of 92.7% for RB diagnosis. These results suggested our assay targeting the TFAP2A ctDNA methylation can be utilized for RB diagnosis and cancer monitoring." @default.
- W3135859770 created "2021-03-15" @default.
- W3135859770 creator A5015402167 @default.
- W3135859770 creator A5071074966 @default.
- W3135859770 creator A5085218435 @default.
- W3135859770 creator A5085663287 @default.
- W3135859770 creator A5090153645 @default.
- W3135859770 date "2021-03-02" @default.
- W3135859770 modified "2023-10-14" @default.
- W3135859770 title "The methylation level of TFAP2A is a potential diagnostic biomarker for retinoblastoma: an analytical validation study" @default.
- W3135859770 cites W1126260776 @default.
- W3135859770 cites W1844379777 @default.
- W3135859770 cites W1975528145 @default.
- W3135859770 cites W1984966593 @default.
- W3135859770 cites W1993214904 @default.
- W3135859770 cites W1995686810 @default.
- W3135859770 cites W2000305484 @default.
- W3135859770 cites W2029787649 @default.
- W3135859770 cites W2045467759 @default.
- W3135859770 cites W2060650722 @default.
- W3135859770 cites W2070379621 @default.
- W3135859770 cites W2079584632 @default.
- W3135859770 cites W2086391240 @default.
- W3135859770 cites W2088287802 @default.
- W3135859770 cites W2298824325 @default.
- W3135859770 cites W2404113298 @default.
- W3135859770 cites W2606903365 @default.
- W3135859770 cites W2727204090 @default.
- W3135859770 cites W2740523213 @default.
- W3135859770 cites W2754078715 @default.
- W3135859770 cites W2767148244 @default.
- W3135859770 cites W2785550069 @default.
- W3135859770 cites W2788091007 @default.
- W3135859770 cites W2793963805 @default.
- W3135859770 cites W2797471265 @default.
- W3135859770 cites W2885182378 @default.
- W3135859770 cites W2900597399 @default.
- W3135859770 cites W2900771557 @default.
- W3135859770 cites W2937196653 @default.
- W3135859770 cites W2952214509 @default.
- W3135859770 cites W2971764330 @default.
- W3135859770 cites W2972416174 @default.
- W3135859770 cites W2984827653 @default.
- W3135859770 cites W3012959001 @default.
- W3135859770 cites W3022650529 @default.
- W3135859770 cites W3026492376 @default.
- W3135859770 cites W3044254950 @default.
- W3135859770 cites W3086276576 @default.
- W3135859770 doi "https://doi.org/10.7717/peerj.10830" @default.
- W3135859770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7934648" @default.
- W3135859770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33717678" @default.
- W3135859770 hasPublicationYear "2021" @default.
- W3135859770 type Work @default.
- W3135859770 sameAs 3135859770 @default.
- W3135859770 citedByCount "4" @default.
- W3135859770 countsByYear W31358597702021 @default.
- W3135859770 countsByYear W31358597702022 @default.
- W3135859770 countsByYear W31358597702023 @default.
- W3135859770 crossrefType "journal-article" @default.
- W3135859770 hasAuthorship W3135859770A5015402167 @default.
- W3135859770 hasAuthorship W3135859770A5071074966 @default.
- W3135859770 hasAuthorship W3135859770A5085218435 @default.
- W3135859770 hasAuthorship W3135859770A5085663287 @default.
- W3135859770 hasAuthorship W3135859770A5090153645 @default.
- W3135859770 hasBestOaLocation W31358597701 @default.
- W3135859770 hasConcept C104317684 @default.
- W3135859770 hasConcept C140173407 @default.
- W3135859770 hasConcept C150194340 @default.
- W3135859770 hasConcept C153911025 @default.
- W3135859770 hasConcept C190727270 @default.
- W3135859770 hasConcept C2776577112 @default.
- W3135859770 hasConcept C2781197716 @default.
- W3135859770 hasConcept C33288867 @default.
- W3135859770 hasConcept C502942594 @default.
- W3135859770 hasConcept C54355233 @default.
- W3135859770 hasConcept C552990157 @default.
- W3135859770 hasConcept C70721500 @default.
- W3135859770 hasConcept C86803240 @default.
- W3135859770 hasConceptScore W3135859770C104317684 @default.
- W3135859770 hasConceptScore W3135859770C140173407 @default.
- W3135859770 hasConceptScore W3135859770C150194340 @default.
- W3135859770 hasConceptScore W3135859770C153911025 @default.
- W3135859770 hasConceptScore W3135859770C190727270 @default.
- W3135859770 hasConceptScore W3135859770C2776577112 @default.
- W3135859770 hasConceptScore W3135859770C2781197716 @default.
- W3135859770 hasConceptScore W3135859770C33288867 @default.
- W3135859770 hasConceptScore W3135859770C502942594 @default.
- W3135859770 hasConceptScore W3135859770C54355233 @default.
- W3135859770 hasConceptScore W3135859770C552990157 @default.
- W3135859770 hasConceptScore W3135859770C70721500 @default.
- W3135859770 hasConceptScore W3135859770C86803240 @default.
- W3135859770 hasLocation W31358597701 @default.
- W3135859770 hasLocation W31358597702 @default.
- W3135859770 hasOpenAccess W3135859770 @default.
- W3135859770 hasPrimaryLocation W31358597701 @default.
- W3135859770 hasRelatedWork W2118210161 @default.
- W3135859770 hasRelatedWork W2132384241 @default.
- W3135859770 hasRelatedWork W2292349056 @default.