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- W3135861642 endingPage "173983" @default.
- W3135861642 startingPage "173983" @default.
- W3135861642 abstract "Genetic and epigenetic alterations have been under concentrated investigations for many years in order to unearth the molecules regulating human cancer pathogenesis. However, the identification of a wide range of dysregulated genes and their protein products has raised a question regarding how the results of this large collection of alterations could converge into a formation of one malignancy. The answer may be found in the signaling cascades that regulate the survival and metabolism of the cells. Aberrancies of each participant molecule of such cascades may well result in augmented viability and unlimited proliferation of cancer cells. Among various signaling pathways, the phosphatidylinositol-3-kinase (PI3K) axis has been shown to be activated in about one-third of human cancers. One of the malignancies that is mostly affected by this axis is gastric cancer (GC), one of the most fatal cancers worldwide. In the present review, we aimed to illustrate the significance of the PI3K/Akt/mTOR axis in the pathogenesis of GC and also provided a wide perspective about the application of the inhibitors of this axis in the therapeutic strategies of this malignancy." @default.
- W3135861642 created "2021-03-15" @default.
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- W3135861642 creator A5056184302 @default.
- W3135861642 creator A5072758074 @default.
- W3135861642 creator A5076707279 @default.
- W3135861642 date "2021-05-01" @default.
- W3135861642 modified "2023-10-14" @default.
- W3135861642 title "The PI3K/Akt/mTOR signaling pathway in gastric cancer; from oncogenic variations to the possibilities for pharmacologic interventions" @default.
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