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- W3135875197 endingPage "276" @default.
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- W3135875197 abstract "Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach their intracellular targets. Our understanding of cellular uptake mechanisms has developed substantially in the past five years. However, these advances in cell biology have not fully translated to the nanoscience and therapeutics literature. Misconceptions surrounding the role of different endocytic pathways and how to study these pathways are hindering progress in developing improved nanoparticle therapies. Here, we summarize the latest insights into cellular uptake mechanisms and pathways. We highlight limitations of current systems to study endocytosis, particularly problems with non-specific inhibitors. We also summarize alternative genetic approaches to robustly probe these pathways and discuss the need to understand how cells endocytose particles in vivo. We hope that this critical assessment of the current methods used in studying nanoparticle uptake will guide future studies at the interface of cell biology and nanomedicine. Successful nanomedicine approaches rely on the efficient cellular uptake of nanoparticles, yet endocytic mechanisms remain challenging to probe. In this Review the authors describe the different cellular endocytic pathways and provide a critical discussion of the available tools and systems for their study." @default.
- W3135875197 created "2021-03-15" @default.
- W3135875197 creator A5001752097 @default.
- W3135875197 creator A5029211283 @default.
- W3135875197 creator A5086995353 @default.
- W3135875197 date "2021-03-01" @default.
- W3135875197 modified "2023-10-18" @default.
- W3135875197 title "Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics" @default.
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