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• W3135891212 endingPage "111007" @default.
• W3135891212 startingPage "111007" @default.
• W3135891212 abstract "A novel bolt-like-blocking nanovalve based on mesoporous silica nanoparticles (MSNs) has developed as a drug carrier, using the modified short peptide as a support and the delivery drug as a bridge for fulfilling the blocking process. The peptide-modified nanoparticle MSN-S-S-NAC-Trp combined with the loaded drug can be used as a carrier with no leakage and be triggered for release by appropriate GSH. The peptide-modified nanoparticles have showed no obvious cytotoxicity and can be internalized into L929 cells; moreover, the doxorubicin loaded nanoparticles incubated with HeLa cells have showed GSH-responsive capability and induced cell apoptosis. Since the chain of the modified peptide on the surface of MSN is not long enough to block the channel via self-assembly process, a bolt-like-blocking model is proposed." @default.
• W3135891212 created "2021-03-15" @default.
• W3135891212 creator A5008979378 @default.
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• W3135891212 date "2021-04-01" @default.
• W3135891212 modified "2023-09-23" @default.
• W3135891212 title "A bolt-like-blocking nanovalve on mesoporous silica nanoparticles for controlled release" @default.
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• W3135891212 doi "https://doi.org/10.1016/j.micromeso.2021.111007" @default.
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