Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135904208> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W3135904208 endingPage "08" @default.
- W3135904208 startingPage "IA" @default.
- W3135904208 abstract "Abstract High parameter single cell analysis has driven deep understanding of immune processes. Using a next-generation single-cell “mass cytometry” platform we quantify surface and cytokine or drug responsive indices of kinase target with 45 or more parameter analyses (e.g. 45 antibodies, viability, nucleic acid content, and relative cell size). Similarly, we have developed two advanced technologies termed MIBI and CODEX that enable deep phenotyping of solid tissue in both fresh frozen and FFPE formats (50 – 100 markers). Collectively, the systems allow for subcellular analysis from the 70nm resolution scale to whole tissue in 3D. I will present evidence of deep internal order in immune functionality demonstrating that differentiation and immune activities have evolved with a definable “shape”. Further, specific cellular neighborhoods of immune cells are now definable with unique abilities to affect cellular phenotypes—and these neighborhoods alter in various cancer disease states. In addition to cancer, these shapes and neighborhoods are altered during immune action and “imprinted” during, and after, pathogen attack, traumatic injury, or auto-immune disease. Hierarchies of functionally defined trans-cellular modules are observed that can be used for mechanistic and clinical insights in cancer and immune therapies. Citation Format: Garry P. Nolan. High parameter single cell analysis has driven deep understanding of immune processes [abstract]. In: Proceedings of the AACR Virtual Special Conference on Artificial Intelligence, Diagnosis, and Imaging; 2021 Jan 13-14. Philadelphia (PA): AACR; Clin Cancer Res 2021;27(5_Suppl):Abstract nr IA-08." @default.
- W3135904208 created "2021-03-15" @default.
- W3135904208 creator A5044213727 @default.
- W3135904208 date "2021-03-01" @default.
- W3135904208 modified "2023-09-27" @default.
- W3135904208 title "Abstract IA-08: High parameter single cell analysis has driven deep understanding of immune processes" @default.
- W3135904208 doi "https://doi.org/10.1158/1557-3265.adi21-ia-08" @default.
- W3135904208 hasPublicationYear "2021" @default.
- W3135904208 type Work @default.
- W3135904208 sameAs 3135904208 @default.
- W3135904208 citedByCount "0" @default.
- W3135904208 crossrefType "journal-article" @default.
- W3135904208 hasAuthorship W3135904208A5044213727 @default.
- W3135904208 hasConcept C104317684 @default.
- W3135904208 hasConcept C121608353 @default.
- W3135904208 hasConcept C127716648 @default.
- W3135904208 hasConcept C132917006 @default.
- W3135904208 hasConcept C141231307 @default.
- W3135904208 hasConcept C1491633281 @default.
- W3135904208 hasConcept C159654299 @default.
- W3135904208 hasConcept C203014093 @default.
- W3135904208 hasConcept C2778015335 @default.
- W3135904208 hasConcept C502942594 @default.
- W3135904208 hasConcept C54355233 @default.
- W3135904208 hasConcept C553184892 @default.
- W3135904208 hasConcept C70721500 @default.
- W3135904208 hasConcept C86803240 @default.
- W3135904208 hasConcept C8891405 @default.
- W3135904208 hasConcept C96232424 @default.
- W3135904208 hasConceptScore W3135904208C104317684 @default.
- W3135904208 hasConceptScore W3135904208C121608353 @default.
- W3135904208 hasConceptScore W3135904208C127716648 @default.
- W3135904208 hasConceptScore W3135904208C132917006 @default.
- W3135904208 hasConceptScore W3135904208C141231307 @default.
- W3135904208 hasConceptScore W3135904208C1491633281 @default.
- W3135904208 hasConceptScore W3135904208C159654299 @default.
- W3135904208 hasConceptScore W3135904208C203014093 @default.
- W3135904208 hasConceptScore W3135904208C2778015335 @default.
- W3135904208 hasConceptScore W3135904208C502942594 @default.
- W3135904208 hasConceptScore W3135904208C54355233 @default.
- W3135904208 hasConceptScore W3135904208C553184892 @default.
- W3135904208 hasConceptScore W3135904208C70721500 @default.
- W3135904208 hasConceptScore W3135904208C86803240 @default.
- W3135904208 hasConceptScore W3135904208C8891405 @default.
- W3135904208 hasConceptScore W3135904208C96232424 @default.
- W3135904208 hasIssue "5_Supplement" @default.
- W3135904208 hasLocation W31359042081 @default.
- W3135904208 hasOpenAccess W3135904208 @default.
- W3135904208 hasPrimaryLocation W31359042081 @default.
- W3135904208 hasRelatedWork W2378785636 @default.
- W3135904208 hasRelatedWork W2386605958 @default.
- W3135904208 hasRelatedWork W2890187591 @default.
- W3135904208 hasRelatedWork W3085337485 @default.
- W3135904208 hasRelatedWork W3136050734 @default.
- W3135904208 hasRelatedWork W3206685145 @default.
- W3135904208 hasRelatedWork W4226150303 @default.
- W3135904208 hasRelatedWork W4283731173 @default.
- W3135904208 hasRelatedWork W4291367166 @default.
- W3135904208 hasRelatedWork W4308359949 @default.
- W3135904208 hasVolume "27" @default.
- W3135904208 isParatext "false" @default.
- W3135904208 isRetracted "false" @default.
- W3135904208 magId "3135904208" @default.
- W3135904208 workType "article" @default.