FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135908056> ?p ?o ?g. }

• W3135908056 endingPage "100263" @default.
• W3135908056 startingPage "100263" @default.
• W3135908056 abstract "Previous studies have identified physical activity as an important lifestyle factor in the pathogenesis of chronic liver diseases (CLD). However, most studies were short in follow-up, and based on self-reported activity. Moreover, it is unknown whether physical activity affects the risk of liver disease development in the general population. Herein, we aimed to clarify the association between physical activity and CLD by examining the risk of liver disease and progression in relation to accelerometer-based physical activity in a large subset of prospectively recruited participants in the UK Biobank.We analysed data from 96,688 participants that recorded their physical activity through the use of a wrist accelerometer. Relative risks for development of liver diseases were calculated using multivariable-adjusted Cox regression models. In a subgroup of participants without any previously diagnosed liver disease (n = 95,974), a total of 374 liver disease cases were diagnosed during follow-up (mean = 5.5 years).Participants in the top compared with the bottom quartile of physical activity had a reduced risk of both overall CLD (hazard ratio [HR]: 0.41 [0.29-0.59]) and NAFLD (HR: 0.39 [0.21-0.70]). An activity increase of an additional 2,500 steps per day, was associated with a 38% reduction in CLD and a 47% reduction in NAFLD development, independent of adiposity. In the subgroup of participants with previously diagnosed liver disease (n = 714), participants in the top compared with the bottom quartile of physical activity had a striking 89% risk reduction in liver-related death (HR: 0.11 [0.02-0.86]), and 85% risk reduction in all-cause mortality (adjusted HR: 0.15 [0.05-0.44]). Walking an additional 2,500 steps per day was associated with 44% reduction in liver disease progression.Greater physical activity is associated with a dose-dependent reduction in liver disease, which appears to be independent of adiposity.In this study, we aimed to clarify the association between accelerometer-measured physical activity and chronic liver disease by examining risk of overall and specific liver diseases and their progression in relation to accelerometer-based physical activity in 96,688 participants in the UK Biobank. Our results show a clear, dose-dependent protective association between accelerometer-measured physical activity and liver disease development and progression. The linkage of device-measured activity could therefore create a framework for using wearables for personalised prevention of liver diseases." @default.
• W3135908056 created "2021-03-15" @default.
• W3135908056 creator A5034132009 @default.
• W3135908056 creator A5036945580 @default.
• W3135908056 creator A5040184864 @default.
• W3135908056 creator A5071354944 @default.
• W3135908056 date "2021-06-01" @default.
• W3135908056 modified "2023-10-15" @default.
• W3135908056 title "Physical activity is associated with reduced risk of liver disease in the prospective UK Biobank cohort" @default.
• W3135908056 cites W1719679710 @default.
• W3135908056 cites W1970765180 @default.
• W3135908056 cites W1984454671 @default.
• W3135908056 cites W1998109668 @default.
• W3135908056 cites W2017032820 @default.
• W3135908056 cites W2034114152 @default.
• W3135908056 cites W2044756609 @default.
• W3135908056 cites W2048164507 @default.
• W3135908056 cites W2056935896 @default.
• W3135908056 cites W2060400927 @default.
• W3135908056 cites W2073263541 @default.
• W3135908056 cites W2075536892 @default.
• W3135908056 cites W2105186409 @default.
• W3135908056 cites W2130478573 @default.
• W3135908056 cites W2155519151 @default.
• W3135908056 cites W2157254871 @default.
• W3135908056 cites W2164604426 @default.
• W3135908056 cites W2169843646 @default.
• W3135908056 cites W2204688218 @default.
• W3135908056 cites W2470168770 @default.
• W3135908056 cites W2471743917 @default.
• W3135908056 cites W2525022598 @default.
• W3135908056 cites W2535376176 @default.
• W3135908056 cites W2566427467 @default.
• W3135908056 cites W2584016859 @default.
• W3135908056 cites W2768551517 @default.
• W3135908056 cites W2774108532 @default.
• W3135908056 cites W2900962412 @default.
• W3135908056 cites W2913133429 @default.
• W3135908056 cites W2931842102 @default.
• W3135908056 cites W2980176227 @default.
• W3135908056 cites W3000017717 @default.
• W3135908056 cites W3011846974 @default.
• W3135908056 cites W3015739657 @default.
• W3135908056 cites W3049300342 @default.
• W3135908056 doi "https://doi.org/10.1016/j.jhepr.2021.100263" @default.
• W3135908056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8056270" @default.
• W3135908056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33898961" @default.
• W3135908056 hasPublicationYear "2021" @default.
• W3135908056 type Work @default.
• W3135908056 sameAs 3135908056 @default.
• W3135908056 citedByCount "22" @default.
• W3135908056 countsByYear W31359080562021 @default.
• W3135908056 countsByYear W31359080562022 @default.
• W3135908056 countsByYear W31359080562023 @default.
• W3135908056 crossrefType "journal-article" @default.
• W3135908056 hasAuthorship W3135908056A5034132009 @default.
• W3135908056 hasAuthorship W3135908056A5036945580 @default.
• W3135908056 hasAuthorship W3135908056A5040184864 @default.
• W3135908056 hasAuthorship W3135908056A5071354944 @default.
• W3135908056 hasBestOaLocation W31359080561 @default.
• W3135908056 hasConcept C116567970 @default.
• W3135908056 hasConcept C126322002 @default.
• W3135908056 hasConcept C1862650 @default.
• W3135908056 hasConcept C188816634 @default.
• W3135908056 hasConcept C201903717 @default.
• W3135908056 hasConcept C207103383 @default.
• W3135908056 hasConcept C2777075537 @default.
• W3135908056 hasConcept C2777214474 @default.
• W3135908056 hasConcept C2779102576 @default.
• W3135908056 hasConcept C2908647359 @default.
• W3135908056 hasConcept C44249647 @default.
• W3135908056 hasConcept C50382708 @default.
• W3135908056 hasConcept C50440223 @default.
• W3135908056 hasConcept C60644358 @default.
• W3135908056 hasConcept C68443243 @default.
• W3135908056 hasConcept C71924100 @default.
• W3135908056 hasConcept C72563966 @default.
• W3135908056 hasConcept C86803240 @default.
• W3135908056 hasConcept C99454951 @default.
• W3135908056 hasConceptScore W3135908056C116567970 @default.
• W3135908056 hasConceptScore W3135908056C126322002 @default.
• W3135908056 hasConceptScore W3135908056C1862650 @default.
• W3135908056 hasConceptScore W3135908056C188816634 @default.
• W3135908056 hasConceptScore W3135908056C201903717 @default.
• W3135908056 hasConceptScore W3135908056C207103383 @default.
• W3135908056 hasConceptScore W3135908056C2777075537 @default.
• W3135908056 hasConceptScore W3135908056C2777214474 @default.
• W3135908056 hasConceptScore W3135908056C2779102576 @default.
• W3135908056 hasConceptScore W3135908056C2908647359 @default.
• W3135908056 hasConceptScore W3135908056C44249647 @default.
• W3135908056 hasConceptScore W3135908056C50382708 @default.
• W3135908056 hasConceptScore W3135908056C50440223 @default.
• W3135908056 hasConceptScore W3135908056C60644358 @default.
• W3135908056 hasConceptScore W3135908056C68443243 @default.
• W3135908056 hasConceptScore W3135908056C71924100 @default.
• W3135908056 hasConceptScore W3135908056C72563966 @default.
• W3135908056 hasConceptScore W3135908056C86803240 @default.
• W3135908056 hasConceptScore W3135908056C99454951 @default.

• next