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- W3135951202 abstract "<h2>Abstract</h2><h3>Aims</h3> Descriptions of sporadic Creutzfeldt-Jakob disease (sCJD) in non-White populations are limited. Improved understanding may aid diagnoses and case ascertainment within surveillance programmes. We aimed to: 1) Ascertain the proportion of sCJD cases with non-White ethnicity in the United Kingdom (UK); 2) Compare clinical and investigation findings between non-White and White cases. <h3>Methods</h3> We analysed records of probable and definite sCJD cases assessed by the UK National CJD Research and Surveillance Unit over 28 years (1990–2017). Cases were stratified into White and non-White groups. Demographics, clinical features, investigation findings, and post-mortem numbers were compared. <h3>Results</h3> 1697 sCJD cases were included: 1642 (97%) White, 55 (3%) non-White (Asian/Asian British, Black/African/Caribbean). The proportion of non-Whites among sCJD cases is 7% lower than the proportion the non-White population make up in the UK (<i>p</i> < 0.001). This was not statistically significant when age-matched by ≥60 years (<i>p</i> = 0.071). Age at symptom onset was 4 years lower in the non-White population (<i>p</i> = 0.007). Clinical and investigation characteristics were otherwise similar between ethnic groupings. The proportion of non-Whites undergoing autopsy and classification as definite was 30% and 24% lower (<i>p</i> < 0.001) respectively in comparison to those for White cases. <h3>Conclusions</h3> Approximately 3% of sCJD cases in the UK are non-White, despite non-Whites representing approximately 10% of the UK population. This difference was not statistically significant when age-matched at ≥60 years. Non-White cases tend to be younger and likelihood of autopsy is lower; relevant considerations for surveillance programmes. Reasons for these differences in non-White populations are unclear and merit further evaluation." @default.
- W3135951202 created "2021-03-29" @default.
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- W3135951202 date "2021-05-01" @default.
- W3135951202 modified "2023-09-26" @default.
- W3135951202 title "Non-white cases of sporadic Creutzfeldt-Jakob disease: A 28 year review of United Kingdom National Surveillance Data" @default.
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- W3135951202 doi "https://doi.org/10.1016/j.jns.2021.117416" @default.
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