FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135954112> ?p ?o ?g. }

• W3135954112 endingPage "S634" @default.
• W3135954112 startingPage "S634" @default.
• W3135954112 abstract "Epidermal growth factor receptor (EGFR) exon 20 insertion mutations have been identified in approximately 4% of non-small cell lung cancer (NSCLC) cases. Many previous works suggested that EGFR exon 20 insertion mutations were generally associated with insensitivity to available tyrosine kinase inhibitors (TKIs). Currently, no standard targeted therapies are approved for NSCLC patients harboring EGFR exon 20 insertion mutations. Next-generation sequencing (NGS) on the tumor tissue was performed. A 71-year-old non-smoker Chinese female was diagnosed with lung adenocarcinoma with multiple metastases in bilateral lung and mass in the right chest with osteolytic bone destruction in the sixth rib in May 2019. The tumor node metastasis (TNM) classification of this patient was T4N3M1. Before treatment, her tumor DNA extracted from tissue was subjected to DNA sequencing analysis using a cancer-gene panel (3D Medicines, Shanghai, China) with next-generation sequencing (NGS). The sequencing results suggested that the patient had a novel EGFR exon 20 insertion mutation (EGFR p. N771delinsKG). The patient started to receive first-line treatment with afatinib (40 mg/day) according to the NGS results in July 2019. Before the treatment, the computed tomography (CT) scans showed that the size of tumor lesions located in left lower lung and right chest were 62.6 mm×60.9 mm and 58.3 mm×46.7 mm respectively. After the treatment of afatinib, one lesion in left lower lung became obscure and unmeasurable, and the tumor size of the other lesion in right chest decreased to 43.7 mm×37.2 mm. According to the response evaluation criteria in solid tumors (RESIST 1.1), she achieved a radiological partial response (PR). Furthermore, no grade 3 or higher adverse events (AEs) occurred. The treatment-related AEs associated with afatinib were grade 1 or 2 diarrhea, skin rash, paronychia and stomatitis without treatment interruption. These AEs occurred during the first month of afatinib treatment and relieved with corresponding symptomatic treatments. Until May 2020, progressive disease was observed due to the enlarged tumor lesions. The final PFS was 10 months. Overall, we reported the first case of a patient with NSCLC harboring a novel EGFR exon 20 insertion mutation (p. N771delinsKG), who benefited from afatinib. Based on this finding, afatinib might be considered as an optimal treatment for NSCLC harboring uncommon EGFR exon 20 insertion mutations. Further investigations need to be carried out." @default.
• W3135954112 created "2021-03-29" @default.
• W3135954112 creator A5016109980 @default.
• W3135954112 creator A5021520299 @default.
• W3135954112 creator A5050116047 @default.
• W3135954112 creator A5051976562 @default.
• W3135954112 creator A5074691262 @default.
• W3135954112 creator A5079960883 @default.
• W3135954112 creator A5083326550 @default.
• W3135954112 date "2021-03-01" @default.
• W3135954112 modified "2023-10-02" @default.
• W3135954112 title "P76.99 Response to Afatinib in a Patient with NSCLC Harboring Novel EGFR Exon 20 Insertion Mutations" @default.
• W3135954112 doi "https://doi.org/10.1016/j.jtho.2021.01.1156" @default.
• W3135954112 hasPublicationYear "2021" @default.
• W3135954112 type Work @default.
• W3135954112 sameAs 3135954112 @default.
• W3135954112 citedByCount "0" @default.
• W3135954112 crossrefType "journal-article" @default.
• W3135954112 hasAuthorship W3135954112A5016109980 @default.
• W3135954112 hasAuthorship W3135954112A5021520299 @default.
• W3135954112 hasAuthorship W3135954112A5050116047 @default.
• W3135954112 hasAuthorship W3135954112A5051976562 @default.
• W3135954112 hasAuthorship W3135954112A5074691262 @default.
• W3135954112 hasAuthorship W3135954112A5079960883 @default.
• W3135954112 hasAuthorship W3135954112A5083326550 @default.
• W3135954112 hasBestOaLocation W31359541121 @default.
• W3135954112 hasConcept C104317684 @default.
• W3135954112 hasConcept C121608353 @default.
• W3135954112 hasConcept C126322002 @default.
• W3135954112 hasConcept C143998085 @default.
• W3135954112 hasConcept C2776256026 @default.
• W3135954112 hasConcept C2777714996 @default.
• W3135954112 hasConcept C2779438470 @default.
• W3135954112 hasConcept C2780580887 @default.
• W3135954112 hasConcept C2780586478 @default.
• W3135954112 hasConcept C2781182431 @default.
• W3135954112 hasConcept C36823959 @default.
• W3135954112 hasConcept C502942594 @default.
• W3135954112 hasConcept C54355233 @default.
• W3135954112 hasConcept C71924100 @default.
• W3135954112 hasConcept C86803240 @default.
• W3135954112 hasConceptScore W3135954112C104317684 @default.
• W3135954112 hasConceptScore W3135954112C121608353 @default.
• W3135954112 hasConceptScore W3135954112C126322002 @default.
• W3135954112 hasConceptScore W3135954112C143998085 @default.
• W3135954112 hasConceptScore W3135954112C2776256026 @default.
• W3135954112 hasConceptScore W3135954112C2777714996 @default.
• W3135954112 hasConceptScore W3135954112C2779438470 @default.
• W3135954112 hasConceptScore W3135954112C2780580887 @default.
• W3135954112 hasConceptScore W3135954112C2780586478 @default.
• W3135954112 hasConceptScore W3135954112C2781182431 @default.
• W3135954112 hasConceptScore W3135954112C36823959 @default.
• W3135954112 hasConceptScore W3135954112C502942594 @default.
• W3135954112 hasConceptScore W3135954112C54355233 @default.
• W3135954112 hasConceptScore W3135954112C71924100 @default.
• W3135954112 hasConceptScore W3135954112C86803240 @default.
• W3135954112 hasIssue "3" @default.
• W3135954112 hasLocation W31359541121 @default.
• W3135954112 hasOpenAccess W3135954112 @default.
• W3135954112 hasPrimaryLocation W31359541121 @default.
• W3135954112 hasRelatedWork W1602357875 @default.
• W3135954112 hasRelatedWork W2772338590 @default.
• W3135954112 hasRelatedWork W2799307105 @default.
• W3135954112 hasRelatedWork W2888534976 @default.
• W3135954112 hasRelatedWork W2907478003 @default.
• W3135954112 hasRelatedWork W4362611067 @default.
• W3135954112 hasRelatedWork W4362621128 @default.
• W3135954112 hasRelatedWork W4364376773 @default.
• W3135954112 hasRelatedWork W4366082921 @default.
• W3135954112 hasRelatedWork W1931533321 @default.
• W3135954112 hasVolume "16" @default.
• W3135954112 isParatext "false" @default.
• W3135954112 isRetracted "false" @default.
• W3135954112 magId "3135954112" @default.
• W3135954112 workType "article" @default.