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• W3135962937 abstract "Hampering-surface presentation of immunogenic peptides by class I/II MHCs is a key strategy opted by several intracellular protozoan pathogens including Leishmania to escape CD8/CD4 mediated host-protective T-cell response. Although Leishmania parasites (LP) primarily hijack/inhibit host lysosomal/proteasomal pathways to hamper antigen-processing/presentation machinery, recent pieces of evidence have linked host-membrane fluidity as a major cause of defective antigen presentation in leishmaniasis. Increased membrane fluidity severely compromised peptide-MHC stability in the lipid raft regions, thereby abrogating T-cell mediated-signalling in the infected host. LP primarily achieves this by quenching host cholesterol, which acts as cementing material in maintaining the membrane fluidity. In this review, we have particularly focused on several strategies opted by LP to hijack-host cholesterol resulting in lipid droplets accumulation around leishmania-containing parasitophorous vacuole favouring intracellular survival of LP. In fact, LP infection can result in altered cholesterol and lipid metabolism in the infected host, thereby favouring the establishment and progression of the infection. From our analysis of two genome-wide transcriptomics data sets of LP infected host, we propose a possible molecular network that connects these interrelated events of altered lipid metabolism with eventual compromised antigen presentation, still existing as a gap in our current understanding of Leishmania infection." @default.
• W3135962937 created "2021-03-29" @default.
• W3135962937 creator A5030089648 @default.
• W3135962937 creator A5056256408 @default.
• W3135962937 creator A5060327738 @default.
• W3135962937 creator A5068495585 @default.
• W3135962937 creator A5074722160 @default.
• W3135962937 date "2021-04-05" @default.
• W3135962937 modified "2023-09-27" @default.
• W3135962937 title "Linking membrane fluidity with defective antigen presentation in leishmaniasis" @default.
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• W3135962937 doi "https://doi.org/10.1111/pim.12835" @default.
• W3135962937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33756007" @default.
• W3135962937 hasPublicationYear "2021" @default.
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• W3135962937 hasAuthorship W3135962937A5060327738 @default.

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