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- W3135963375 abstract "Abstract The design and synthesis of a novel acid‐degradable polyethylene glycol‐based N ‐hydroxysuccinimide (NHS) ester‐activated crosslinker is reported. The crosslinker is reactive towards nucleophiles and features a central ketal functional group that is stable at pH > 7.5 and rapidly hydrolyses at pH > 6.0. The crosslinker is used to (i) fabricate acid‐degradable polysaccharide hydrogels that exhibit controlled degradation upon exposure to an acidic environment or via endogenous enzyme activity; and (ii) construct hydrogel‐filled protein‐polymer microcompartments (termed proteinosomes ) capable of pH‐dependent membrane disassembly. Taken together the results provide new opportunities for the fabrication of pH‐responsive soft materials with potential applications in drug delivery, tissue engineering, and soft‐matter bioengineering." @default.
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- W3135963375 date "2021-03-22" @default.
- W3135963375 modified "2023-10-18" @default.
- W3135963375 title "A Novel Acid‐Degradable PEG Crosslinker for the Fabrication of pH‐Responsive Soft Materials" @default.
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- W3135963375 doi "https://doi.org/10.1002/marc.202100102" @default.
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