FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136011479> ?p ?o ?g. }

• W3136011479 endingPage "3875" @default.
• W3136011479 startingPage "3856" @default.
• W3136011479 abstract "Abstract The glucocorticoid (GR) and androgen (AR) receptors execute unique functions in vivo, yet have nearly identical DNA binding specificities. To identify mechanisms that facilitate functional diversification among these transcription factor paralogs, we studied them in an equivalent cellular context. Analysis of chromatin and sequence suggest that divergent binding, and corresponding gene regulation, are driven by different abilities of AR and GR to interact with relatively inaccessible chromatin. Divergent genomic binding patterns can also be the result of subtle differences in DNA binding preference between AR and GR. Furthermore, the sequence composition of large regions (&gt;10 kb) surrounding selectively occupied binding sites differs significantly, indicating a role for the sequence environment in guiding AR and GR to distinct binding sites. The comparison of binding sites that are shared shows that the specificity paradox can also be resolved by differences in the events that occur downstream of receptor binding. Specifically, shared binding sites display receptor-specific enhancer activity, cofactor recruitment and changes in histone modifications. Genomic deletion of shared binding sites demonstrates their contribution to directing receptor-specific gene regulation. Together, these data suggest that differences in genomic occupancy as well as divergence in the events that occur downstream of receptor binding direct functional diversification among transcription factor paralogs." @default.
• W3136011479 created "2021-03-29" @default.
• W3136011479 creator A5003731125 @default.
• W3136011479 creator A5005424746 @default.
• W3136011479 creator A5026926427 @default.
• W3136011479 creator A5027706602 @default.
• W3136011479 creator A5029485498 @default.
• W3136011479 creator A5037570217 @default.
• W3136011479 creator A5061531314 @default.
• W3136011479 creator A5065896666 @default.
• W3136011479 creator A5069842603 @default.
• W3136011479 creator A5071406734 @default.
• W3136011479 creator A5071652132 @default.
• W3136011479 creator A5078298172 @default.
• W3136011479 date "2021-03-22" @default.
• W3136011479 modified "2023-10-01" @default.
• W3136011479 title "Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites" @default.
• W3136011479 cites W1964963969 @default.
• W3136011479 cites W1977709885 @default.
• W3136011479 cites W197844582 @default.
• W3136011479 cites W1979513200 @default.
• W3136011479 cites W1981030303 @default.
• W3136011479 cites W1982519328 @default.
• W3136011479 cites W1993502678 @default.
• W3136011479 cites W1994609038 @default.
• W3136011479 cites W1998000745 @default.
• W3136011479 cites W1998547458 @default.
• W3136011479 cites W1999319214 @default.
• W3136011479 cites W2003171404 @default.
• W3136011479 cites W2025919590 @default.
• W3136011479 cites W2036176224 @default.
• W3136011479 cites W2046489321 @default.
• W3136011479 cites W2053427642 @default.
• W3136011479 cites W2068478010 @default.
• W3136011479 cites W2071350501 @default.
• W3136011479 cites W2076113315 @default.
• W3136011479 cites W2077503648 @default.
• W3136011479 cites W2077854579 @default.
• W3136011479 cites W2077874719 @default.
• W3136011479 cites W2078798531 @default.
• W3136011479 cites W2080748037 @default.
• W3136011479 cites W2084620487 @default.
• W3136011479 cites W2087058596 @default.
• W3136011479 cites W2090456077 @default.
• W3136011479 cites W2102619694 @default.
• W3136011479 cites W2102824660 @default.
• W3136011479 cites W2105623411 @default.
• W3136011479 cites W2108234281 @default.
• W3136011479 cites W2116152510 @default.
• W3136011479 cites W2117757143 @default.
• W3136011479 cites W2119969731 @default.
• W3136011479 cites W2122429294 @default.
• W3136011479 cites W2123106337 @default.
• W3136011479 cites W2123436615 @default.
• W3136011479 cites W2128251898 @default.
• W3136011479 cites W2129785061 @default.
• W3136011479 cites W2130410032 @default.
• W3136011479 cites W2135060880 @default.
• W3136011479 cites W2143172590 @default.
• W3136011479 cites W2144091055 @default.
• W3136011479 cites W2149627698 @default.
• W3136011479 cites W2149992318 @default.
• W3136011479 cites W2154746182 @default.
• W3136011479 cites W2155373993 @default.
• W3136011479 cites W2155844132 @default.
• W3136011479 cites W2156449475 @default.
• W3136011479 cites W2156661861 @default.
• W3136011479 cites W2157009395 @default.
• W3136011479 cites W2158074192 @default.
• W3136011479 cites W2158789637 @default.
• W3136011479 cites W2159942968 @default.
• W3136011479 cites W2160975559 @default.
• W3136011479 cites W2167807351 @default.
• W3136011479 cites W2169381378 @default.
• W3136011479 cites W2169456326 @default.
• W3136011479 cites W2170551349 @default.
• W3136011479 cites W2171808845 @default.
• W3136011479 cites W2179438025 @default.
• W3136011479 cites W2211412171 @default.
• W3136011479 cites W2259938310 @default.
• W3136011479 cites W2269247182 @default.
• W3136011479 cites W2353444611 @default.
• W3136011479 cites W2575997426 @default.
• W3136011479 cites W2587654187 @default.
• W3136011479 cites W2623543676 @default.
• W3136011479 cites W2626354035 @default.
• W3136011479 cites W2745343063 @default.
• W3136011479 cites W2756240008 @default.
• W3136011479 cites W2767948671 @default.
• W3136011479 cites W2770178180 @default.
• W3136011479 cites W2772841828 @default.
• W3136011479 cites W2786356824 @default.
• W3136011479 cites W2790867006 @default.
• W3136011479 cites W2794737870 @default.
• W3136011479 cites W2945999435 @default.
• W3136011479 cites W2949152404 @default.
• W3136011479 cites W2950190910 @default.
• W3136011479 cites W2952109315 @default.

• next