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• W3136014681 abstract "Newly emerging transformed cells are often eliminated from the epithelium via cell competition with the surrounding normal cells. A number of recent studies using mammalian cell competition systems have demonstrated that cells with various types of oncogenic insults are extruded from the tissue in a cell death-dependent or -independent manner. Cell competition-mediated elimination of transformed cells, called EDAC (epithelial defense against cancer), represents an intrinsic anti-tumor activity within the epithelial cell society to reduce the risk of oncogenesis. Here we delineate roles and molecular mechanisms of this homeostatic process, especially focusing on mammalian models . • EDAC-mediated elimination of transformed cells governs the tissue homeostasis. • Dual modes of EDAC function to eradicate transformed cells. • We review recent advances on EDAC in mammalian models. • EDAC-induced apical elimination of transformed cells requires elaborate biological processes." @default.
• W3136014681 created "2021-03-29" @default.
• W3136014681 creator A5003775933 @default.
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• W3136014681 date "2021-08-01" @default.
• W3136014681 modified "2023-10-17" @default.
• W3136014681 title "Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis" @default.
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• W3136014681 doi "https://doi.org/10.1016/j.ydbio.2021.03.015" @default.
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