Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136016551> ?p ?o ?g. }
- W3136016551 endingPage "e1009446" @default.
- W3136016551 startingPage "e1009446" @default.
- W3136016551 abstract "RIG-I and MDA5 are cytoplasmic RNA sensors that mediate cell intrinsic immunity against viral pathogens. While it has been well-established that RIG-I and MDA5 recognize RNA viruses, their interactive network with DNA viruses, including herpes simplex virus 1 (HSV-1), remains less clear. Using a combination of RNA-deep sequencing and genetic studies, we show that the γ134.5 gene product, a virus-encoded virulence factor, enables HSV growth by neutralization of RIG-I dependent restriction. When expressed in mammalian cells, HSV-1 γ134.5 targets RIG-I, which cripples cytosolic RNA sensing and subsequently suppresses antiviral gene expression. Rather than inhibition of RIG-I K63-linked ubiquitination, the γ134.5 protein precludes the assembly of RIG-I and cellular chaperone 14-3-3ε into an active complex for mitochondrial translocation. The γ134.5-mediated inhibition of RIG-I-14-3-3ε binding abrogates the access of RIG-I to mitochondrial antiviral-signaling protein (MAVS) and activation of interferon regulatory factor 3. As such, unlike wild type virus HSV-1, a recombinant HSV-1 in which γ134.5 is deleted elicits efficient cytokine induction and replicates poorly, while genetic ablation of RIG-I expression, but not of MDA5 expression, rescues viral growth. Collectively, these findings suggest that viral suppression of cytosolic RNA sensing is a key determinant in the evolutionary arms race of a large DNA virus and its host." @default.
- W3136016551 created "2021-03-29" @default.
- W3136016551 creator A5007705084 @default.
- W3136016551 creator A5014248531 @default.
- W3136016551 creator A5016975145 @default.
- W3136016551 creator A5031994519 @default.
- W3136016551 creator A5045918641 @default.
- W3136016551 creator A5058800828 @default.
- W3136016551 creator A5064050857 @default.
- W3136016551 creator A5082334776 @default.
- W3136016551 date "2021-03-26" @default.
- W3136016551 modified "2023-10-17" @default.
- W3136016551 title "The herpesvirus accessory protein γ134.5 facilitates viral replication by disabling mitochondrial translocation of RIG-I" @default.
- W3136016551 cites W1523693806 @default.
- W3136016551 cites W1915759986 @default.
- W3136016551 cites W1954928472 @default.
- W3136016551 cites W1963614469 @default.
- W3136016551 cites W1970010476 @default.
- W3136016551 cites W1977457899 @default.
- W3136016551 cites W1980477679 @default.
- W3136016551 cites W1981400752 @default.
- W3136016551 cites W1983813078 @default.
- W3136016551 cites W1985240283 @default.
- W3136016551 cites W1985932355 @default.
- W3136016551 cites W1986360322 @default.
- W3136016551 cites W1986536654 @default.
- W3136016551 cites W1990776313 @default.
- W3136016551 cites W1998342624 @default.
- W3136016551 cites W2005121650 @default.
- W3136016551 cites W2008747535 @default.
- W3136016551 cites W2010067084 @default.
- W3136016551 cites W2013092102 @default.
- W3136016551 cites W2013787271 @default.
- W3136016551 cites W2014190963 @default.
- W3136016551 cites W2025335306 @default.
- W3136016551 cites W2031182394 @default.
- W3136016551 cites W2038698914 @default.
- W3136016551 cites W2040589516 @default.
- W3136016551 cites W2048030072 @default.
- W3136016551 cites W2052533199 @default.
- W3136016551 cites W2056795270 @default.
- W3136016551 cites W2060004514 @default.
- W3136016551 cites W2060922355 @default.
- W3136016551 cites W2067706259 @default.
- W3136016551 cites W2068551986 @default.
- W3136016551 cites W2075666178 @default.
- W3136016551 cites W2084603524 @default.
- W3136016551 cites W2085192138 @default.
- W3136016551 cites W2086138941 @default.
- W3136016551 cites W2093256171 @default.
- W3136016551 cites W2093336713 @default.
- W3136016551 cites W2093579074 @default.
- W3136016551 cites W2099610218 @default.
- W3136016551 cites W2100837670 @default.
- W3136016551 cites W2103447184 @default.
- W3136016551 cites W2109274792 @default.
- W3136016551 cites W2110065044 @default.
- W3136016551 cites W2113215587 @default.
- W3136016551 cites W2113560985 @default.
- W3136016551 cites W2114104545 @default.
- W3136016551 cites W2114570899 @default.
- W3136016551 cites W2116803339 @default.
- W3136016551 cites W2123586959 @default.
- W3136016551 cites W2127483144 @default.
- W3136016551 cites W2127824262 @default.
- W3136016551 cites W2130116522 @default.
- W3136016551 cites W2130410032 @default.
- W3136016551 cites W2131617804 @default.
- W3136016551 cites W2131617989 @default.
- W3136016551 cites W2138207763 @default.
- W3136016551 cites W2140354916 @default.
- W3136016551 cites W2141137217 @default.
- W3136016551 cites W2150058561 @default.
- W3136016551 cites W2153342952 @default.
- W3136016551 cites W2154322581 @default.
- W3136016551 cites W2157191168 @default.
- W3136016551 cites W2160810061 @default.
- W3136016551 cites W2162470976 @default.
- W3136016551 cites W2169456326 @default.
- W3136016551 cites W2193575192 @default.
- W3136016551 cites W2307244008 @default.
- W3136016551 cites W2519023924 @default.
- W3136016551 cites W2525729338 @default.
- W3136016551 cites W2530130883 @default.
- W3136016551 cites W2537689739 @default.
- W3136016551 cites W2549958644 @default.
- W3136016551 cites W2562644378 @default.
- W3136016551 cites W2594415105 @default.
- W3136016551 cites W2612912395 @default.
- W3136016551 cites W2724149674 @default.
- W3136016551 cites W2748329964 @default.
- W3136016551 cites W2750781282 @default.
- W3136016551 cites W2766643218 @default.
- W3136016551 cites W2770844838 @default.
- W3136016551 cites W2785075316 @default.
- W3136016551 cites W2801310804 @default.
- W3136016551 cites W2809981814 @default.
- W3136016551 cites W2884159692 @default.