Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136017362> ?p ?o ?g. }
- W3136017362 abstract "Abstract Background The current pandemic of the SARS-CoV-2 virus, widely known as COVID-19, has affected millions of people around the world. The World Health Organization (WHO) has recommended vigorous testing to differentiate SARS-CoV-2 from other respiratory infections to aid in guiding appropriate care and management. Situations like this have demanded robust testing strategies and pooled testing of samples for SARS-CoV-2 virus has provided the solution to mass screening of people for COVID-19. A pooled testing strategy can be very effective in testing when resources are limited, yet it comes with its own limitations. These benefits and limitations need critical consideration when it comes to testing highly infectious diseases like COVID-19. Methods This study evaluated the pooled testing of nasopharyngeal swabs for SARS-COV-2 by comparing the sensitivity of individual sample testing with 4-and 8-pool sample testing. Median cycle threshold (Ct) values were compared, and the precision of pooled testing was assessed through an inter- and intra-assay of pooled samples. Coefficient of variance was calculated for inter- and intra-assay variability. Results The sensitivity becomes considerably lower when the samples are pooled. There is a high percentage of false negative reports with larger sample pool size and when the patient viral load is low or weak positive samples. High variability was seen in the intra- and inter-assay, especially among weak positive samples and when more number of samples are pooled together. Conclusion As COVID − 19 infection numbers and need for testing remain high, we must meticulously evaluate the testing strategy for each country depending on its testing capacity, infrastructure, economic strength, and need to determine the optimal balance on the cost-effective strategy of resource saving and risk/ cost of missing positive patients." @default.
- W3136017362 created "2021-03-29" @default.
- W3136017362 creator A5008137443 @default.
- W3136017362 creator A5016094684 @default.
- W3136017362 creator A5031407568 @default.
- W3136017362 creator A5036683780 @default.
- W3136017362 creator A5057345901 @default.
- W3136017362 creator A5076840553 @default.
- W3136017362 creator A5088654181 @default.
- W3136017362 date "2021-04-17" @default.
- W3136017362 modified "2023-10-10" @default.
- W3136017362 title "Evaluation of pooling of samples for testing SARS-CoV- 2 for mass screening of COVID-19" @default.
- W3136017362 cites W3013907808 @default.
- W3136017362 cites W3014846055 @default.
- W3136017362 cites W3016677553 @default.
- W3136017362 cites W3019625944 @default.
- W3136017362 cites W3022676039 @default.
- W3136017362 cites W3023086180 @default.
- W3136017362 cites W3023881891 @default.
- W3136017362 cites W3036064703 @default.
- W3136017362 cites W3036757363 @default.
- W3136017362 cites W3041479969 @default.
- W3136017362 cites W3046638841 @default.
- W3136017362 cites W3047349135 @default.
- W3136017362 cites W3048081793 @default.
- W3136017362 cites W3080119772 @default.
- W3136017362 cites W3088968345 @default.
- W3136017362 cites W3097962031 @default.
- W3136017362 cites W3098533462 @default.
- W3136017362 cites W3102923109 @default.
- W3136017362 cites W3111916089 @default.
- W3136017362 cites W4256733558 @default.
- W3136017362 doi "https://doi.org/10.1186/s12879-021-06061-3" @default.
- W3136017362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8052526" @default.
- W3136017362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33865325" @default.
- W3136017362 hasPublicationYear "2021" @default.
- W3136017362 type Work @default.
- W3136017362 sameAs 3136017362 @default.
- W3136017362 citedByCount "22" @default.
- W3136017362 countsByYear W31360173622021 @default.
- W3136017362 countsByYear W31360173622022 @default.
- W3136017362 countsByYear W31360173622023 @default.
- W3136017362 crossrefType "journal-article" @default.
- W3136017362 hasAuthorship W3136017362A5008137443 @default.
- W3136017362 hasAuthorship W3136017362A5016094684 @default.
- W3136017362 hasAuthorship W3136017362A5031407568 @default.
- W3136017362 hasAuthorship W3136017362A5036683780 @default.
- W3136017362 hasAuthorship W3136017362A5057345901 @default.
- W3136017362 hasAuthorship W3136017362A5076840553 @default.
- W3136017362 hasAuthorship W3136017362A5088654181 @default.
- W3136017362 hasBestOaLocation W31360173621 @default.
- W3136017362 hasConcept C105795698 @default.
- W3136017362 hasConcept C126322002 @default.
- W3136017362 hasConcept C129848803 @default.
- W3136017362 hasConcept C154945302 @default.
- W3136017362 hasConcept C159047783 @default.
- W3136017362 hasConcept C190139176 @default.
- W3136017362 hasConcept C2779134260 @default.
- W3136017362 hasConcept C3007834351 @default.
- W3136017362 hasConcept C3008058167 @default.
- W3136017362 hasConcept C33923547 @default.
- W3136017362 hasConcept C41008148 @default.
- W3136017362 hasConcept C524204448 @default.
- W3136017362 hasConcept C70437156 @default.
- W3136017362 hasConcept C71924100 @default.
- W3136017362 hasConcept C89623803 @default.
- W3136017362 hasConceptScore W3136017362C105795698 @default.
- W3136017362 hasConceptScore W3136017362C126322002 @default.
- W3136017362 hasConceptScore W3136017362C129848803 @default.
- W3136017362 hasConceptScore W3136017362C154945302 @default.
- W3136017362 hasConceptScore W3136017362C159047783 @default.
- W3136017362 hasConceptScore W3136017362C190139176 @default.
- W3136017362 hasConceptScore W3136017362C2779134260 @default.
- W3136017362 hasConceptScore W3136017362C3007834351 @default.
- W3136017362 hasConceptScore W3136017362C3008058167 @default.
- W3136017362 hasConceptScore W3136017362C33923547 @default.
- W3136017362 hasConceptScore W3136017362C41008148 @default.
- W3136017362 hasConceptScore W3136017362C524204448 @default.
- W3136017362 hasConceptScore W3136017362C70437156 @default.
- W3136017362 hasConceptScore W3136017362C71924100 @default.
- W3136017362 hasConceptScore W3136017362C89623803 @default.
- W3136017362 hasIssue "1" @default.
- W3136017362 hasLocation W31360173621 @default.
- W3136017362 hasLocation W31360173622 @default.
- W3136017362 hasLocation W31360173623 @default.
- W3136017362 hasLocation W31360173624 @default.
- W3136017362 hasOpenAccess W3136017362 @default.
- W3136017362 hasPrimaryLocation W31360173621 @default.
- W3136017362 hasRelatedWork W3017171836 @default.
- W3136017362 hasRelatedWork W3025176011 @default.
- W3136017362 hasRelatedWork W3027835066 @default.
- W3136017362 hasRelatedWork W3032320397 @default.
- W3136017362 hasRelatedWork W3033635008 @default.
- W3136017362 hasRelatedWork W3119540162 @default.
- W3136017362 hasRelatedWork W3152606407 @default.
- W3136017362 hasRelatedWork W4280491013 @default.
- W3136017362 hasRelatedWork W4308017287 @default.
- W3136017362 hasRelatedWork W3107152225 @default.
- W3136017362 hasVolume "21" @default.
- W3136017362 isParatext "false" @default.