Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136057191> ?p ?o ?g. }
- W3136057191 endingPage "40" @default.
- W3136057191 startingPage "30" @default.
- W3136057191 abstract "Acute respiratory infections caused by influenza A virus (IAV) spread widely and lead to substantial morbidity and mortality. Host cell induction of type I interferon (IFN-I) plays a fundamental role in eliminating the virus during the innate antiviral response. The potential role of N-myc and STAT interactor (NMI) and its underlying mechanisms of action during IAV infection, however, remain elusive. In this study, we found that the expression of NMI increased after IAV infection. Nmi-knockout mice infected with IAV displayed increased survival rate, decreased weight loss, lower viral replication, and attenuated lung inflammation when compared with wild-type mice. Deficiency of NMI promoted the production of IFN-I and IFN-stimulated genes in vivo and in vitro. Reduced levels of NMI also resulted in an increase of the expression of IFN regulator factor (IRF) 7. Further studies have revealed that NMI could interact with IRF7 after IAV infection, and this interaction involved its NID1 and NID2 domain. In addition, NMI facilitated ubiquitination and proteasome-dependent degradation of IRF7 through recruitment of the E3 ubiquitin ligase TRIM21 (tripartite motif-containing 21) to limit the IAV-triggered innate immunity. Our findings reveal a clearer understanding of the role of NMI in regulating the host innate antiviral response and provide a potential therapeutic target for controlling IAV infection." @default.
- W3136057191 created "2021-03-29" @default.
- W3136057191 creator A5015114845 @default.
- W3136057191 creator A5019120402 @default.
- W3136057191 creator A5022069770 @default.
- W3136057191 creator A5040495727 @default.
- W3136057191 creator A5058451144 @default.
- W3136057191 creator A5069299119 @default.
- W3136057191 date "2021-07-01" @default.
- W3136057191 modified "2023-09-26" @default.
- W3136057191 title "NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21" @default.
- W3136057191 cites W1254225346 @default.
- W3136057191 cites W1771741017 @default.
- W3136057191 cites W1869071094 @default.
- W3136057191 cites W1951864429 @default.
- W3136057191 cites W1968458610 @default.
- W3136057191 cites W1977548433 @default.
- W3136057191 cites W1980727752 @default.
- W3136057191 cites W1987334631 @default.
- W3136057191 cites W2005884645 @default.
- W3136057191 cites W2011678998 @default.
- W3136057191 cites W2019965289 @default.
- W3136057191 cites W2023262974 @default.
- W3136057191 cites W2026833958 @default.
- W3136057191 cites W2040267633 @default.
- W3136057191 cites W2040527513 @default.
- W3136057191 cites W2049933929 @default.
- W3136057191 cites W2049985537 @default.
- W3136057191 cites W2052046406 @default.
- W3136057191 cites W2062278858 @default.
- W3136057191 cites W2064918308 @default.
- W3136057191 cites W2077942286 @default.
- W3136057191 cites W2083069444 @default.
- W3136057191 cites W2091129202 @default.
- W3136057191 cites W2094899168 @default.
- W3136057191 cites W2095766576 @default.
- W3136057191 cites W2106368852 @default.
- W3136057191 cites W2106772621 @default.
- W3136057191 cites W2111724750 @default.
- W3136057191 cites W2116778443 @default.
- W3136057191 cites W2124911348 @default.
- W3136057191 cites W2145460770 @default.
- W3136057191 cites W2147640266 @default.
- W3136057191 cites W2148690764 @default.
- W3136057191 cites W2166623529 @default.
- W3136057191 cites W2175166656 @default.
- W3136057191 cites W2219188266 @default.
- W3136057191 cites W2377781519 @default.
- W3136057191 cites W2738641035 @default.
- W3136057191 cites W2763277113 @default.
- W3136057191 cites W2767039566 @default.
- W3136057191 cites W2820518421 @default.
- W3136057191 cites W2914019546 @default.
- W3136057191 cites W2927511963 @default.
- W3136057191 cites W2951538424 @default.
- W3136057191 cites W2990384551 @default.
- W3136057191 cites W2991413733 @default.
- W3136057191 doi "https://doi.org/10.1165/rcmb.2020-0391oc" @default.
- W3136057191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33761305" @default.
- W3136057191 hasPublicationYear "2021" @default.
- W3136057191 type Work @default.
- W3136057191 sameAs 3136057191 @default.
- W3136057191 citedByCount "10" @default.
- W3136057191 countsByYear W31360571912021 @default.
- W3136057191 countsByYear W31360571912022 @default.
- W3136057191 countsByYear W31360571912023 @default.
- W3136057191 crossrefType "journal-article" @default.
- W3136057191 hasAuthorship W3136057191A5015114845 @default.
- W3136057191 hasAuthorship W3136057191A5019120402 @default.
- W3136057191 hasAuthorship W3136057191A5022069770 @default.
- W3136057191 hasAuthorship W3136057191A5040495727 @default.
- W3136057191 hasAuthorship W3136057191A5058451144 @default.
- W3136057191 hasAuthorship W3136057191A5069299119 @default.
- W3136057191 hasConcept C104317684 @default.
- W3136057191 hasConcept C134459356 @default.
- W3136057191 hasConcept C136449434 @default.
- W3136057191 hasConcept C140704245 @default.
- W3136057191 hasConcept C159047783 @default.
- W3136057191 hasConcept C203014093 @default.
- W3136057191 hasConcept C2522874641 @default.
- W3136057191 hasConcept C25602115 @default.
- W3136057191 hasConcept C2776178377 @default.
- W3136057191 hasConcept C2776966659 @default.
- W3136057191 hasConcept C2777546802 @default.
- W3136057191 hasConcept C2780209191 @default.
- W3136057191 hasConcept C32300475 @default.
- W3136057191 hasConcept C55493867 @default.
- W3136057191 hasConcept C86339819 @default.
- W3136057191 hasConcept C86803240 @default.
- W3136057191 hasConcept C8891405 @default.
- W3136057191 hasConcept C9173399 @default.
- W3136057191 hasConceptScore W3136057191C104317684 @default.
- W3136057191 hasConceptScore W3136057191C134459356 @default.
- W3136057191 hasConceptScore W3136057191C136449434 @default.
- W3136057191 hasConceptScore W3136057191C140704245 @default.
- W3136057191 hasConceptScore W3136057191C159047783 @default.
- W3136057191 hasConceptScore W3136057191C203014093 @default.
- W3136057191 hasConceptScore W3136057191C2522874641 @default.