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- W3136061698 abstract "Somatostatin (SST) and somatostatin receptors (SSTRs) play an important role in the brain and gastrointestinal (GI) system. SST is produced in various organs and cells, and the inhibitory function of somatostatin-containing cells is involved in a range of physiological functions and pathological modifications. The GI system is the largest endocrine organ for digestion and absorption, SST-endocrine cells and neurons in the GI system are a critical effecter to maintain homeostasis via SSTRs 1-5 and co-receptors, while SST-SSTRs are involved in chemo-sensory, mucus, and hormone secretion, motility, inflammation response, itch, and pain via the autocrine, paracrine, endocrine, and exoendocrine pathways. It is also a power inhibitor for tumor cell proliferation, severe inflammation, and post-operation complications, and is a first-line anti-cancer drug in clinical practice. This mini review focuses on the current function of producing SST endocrine cells and local neurons SST-SSTRs in the GI system, discusses new development prognostic markers, phosphate-specific antibodies, and molecular imaging emerging in diagnostics and therapy, and summarizes the mechanism of the SST family in basic research and clinical practice. Understanding of endocrines and neuroendocrines in SST-SSTRs in GI will provide an insight into advanced medicine in basic and clinical research." @default.
- W3136061698 created "2021-03-29" @default.
- W3136061698 creator A5030627692 @default.
- W3136061698 creator A5037146801 @default.
- W3136061698 creator A5066155047 @default.
- W3136061698 creator A5066267808 @default.
- W3136061698 creator A5084138424 @default.
- W3136061698 date "2021-03-16" @default.
- W3136061698 modified "2023-10-06" @default.
- W3136061698 title "Versatile Functions of Somatostatin and Somatostatin Receptors in the Gastrointestinal System" @default.
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