FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136074699> ?p ?o ?g. }

• W3136074699 endingPage "445" @default.
• W3136074699 startingPage "438" @default.
• W3136074699 abstract "Dengue virus (DENV) infection is mostly prevalent in tropical and sub-tropical regions of the world. Though most DENV infections are self-limiting febrile like-illness, a small proportion of secondary infection is fatal, if untreated symptomatically. Among various factors involved in severe dengue, immune enhancement by cytokine is the major one. The objective of the study is to elucidate serum cytokine expression among primary and secondary infection and determine if any signature cytokine is correlated with disease severity. Seventy-six serum samples at acute time points were collected during the 2017 DENV outbreak in Madurai, Tamil Nadu. Among the 76 serum samples, 49 belong to primary and 27 to secondary DENV infection. Interestingly, a large number of primary infection presented with DHF/DSS symptoms and, children were found prone to DHF and DSS in secondary infection. The serum samples were analysed for inflammatory cytokines, namely IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17A, IFN-γ, TNF-α, IP-10 and GM-CSF using ELISA assay as well as mRNA analysis using qPCR. Among the 12 inflammatory cytokines analysed IP-10 and GMCSF mRNA and protein shows significant upregulation in secondary infection. Similarly, a strong correlation was observed between GM-CSF and IP-10 with thrombocytopenia, ascites, serous effusion and spontaneous bleeding. Based on the observations, GM-CSF and IP-10 could be a potential prognostic biomarkers for secondary DENV infection." @default.
• W3136074699 created "2021-03-29" @default.
• W3136074699 creator A5048445348 @default.
• W3136074699 creator A5072962826 @default.
• W3136074699 date "2021-06-01" @default.
• W3136074699 modified "2023-09-25" @default.
• W3136074699 title "Cytokine IP-10 and GM-CSF are prognostic biomarkers for severity in secondary dengue infection" @default.
• W3136074699 cites W1570191940 @default.
• W3136074699 cites W1620079123 @default.
• W3136074699 cites W1777780029 @default.
• W3136074699 cites W1904386998 @default.
• W3136074699 cites W1959061129 @default.
• W3136074699 cites W1976958872 @default.
• W3136074699 cites W1980143030 @default.
• W3136074699 cites W1997491414 @default.
• W3136074699 cites W2000730994 @default.
• W3136074699 cites W2001410517 @default.
• W3136074699 cites W2001866502 @default.
• W3136074699 cites W2007781148 @default.
• W3136074699 cites W2012279425 @default.
• W3136074699 cites W2013054229 @default.
• W3136074699 cites W2018438873 @default.
• W3136074699 cites W2027185875 @default.
• W3136074699 cites W2035541724 @default.
• W3136074699 cites W2043930556 @default.
• W3136074699 cites W2053306858 @default.
• W3136074699 cites W2065497934 @default.
• W3136074699 cites W2069197869 @default.
• W3136074699 cites W2070210577 @default.
• W3136074699 cites W2080395015 @default.
• W3136074699 cites W2081020320 @default.
• W3136074699 cites W2082278155 @default.
• W3136074699 cites W2084236775 @default.
• W3136074699 cites W2095461325 @default.
• W3136074699 cites W2100185080 @default.
• W3136074699 cites W2107277218 @default.
• W3136074699 cites W2109265452 @default.
• W3136074699 cites W2110628545 @default.
• W3136074699 cites W2113669223 @default.
• W3136074699 cites W2118726943 @default.
• W3136074699 cites W2119817288 @default.
• W3136074699 cites W2125904929 @default.
• W3136074699 cites W2131112023 @default.
• W3136074699 cites W2134435798 @default.
• W3136074699 cites W2137138056 @default.
• W3136074699 cites W2156938943 @default.
• W3136074699 cites W2161074777 @default.
• W3136074699 cites W2165338511 @default.
• W3136074699 cites W2167017590 @default.
• W3136074699 cites W2180866574 @default.
• W3136074699 cites W2256356363 @default.
• W3136074699 cites W2260854250 @default.
• W3136074699 cites W2268759776 @default.
• W3136074699 cites W2274083554 @default.
• W3136074699 cites W2297808287 @default.
• W3136074699 cites W2339085646 @default.
• W3136074699 cites W2339270564 @default.
• W3136074699 cites W2403980193 @default.
• W3136074699 cites W2464992808 @default.
• W3136074699 cites W2534871897 @default.
• W3136074699 cites W2560217615 @default.
• W3136074699 cites W2583681475 @default.
• W3136074699 cites W2604923378 @default.
• W3136074699 cites W2607074353 @default.
• W3136074699 cites W2686440742 @default.
• W3136074699 cites W2789468013 @default.
• W3136074699 cites W2799946792 @default.
• W3136074699 cites W2883541885 @default.
• W3136074699 cites W2886357148 @default.
• W3136074699 cites W2896581424 @default.
• W3136074699 cites W2910997220 @default.
• W3136074699 cites W2978577943 @default.
• W3136074699 cites W3000890074 @default.
• W3136074699 cites W3091465752 @default.
• W3136074699 cites W41621885 @default.
• W3136074699 cites W4211002680 @default.
• W3136074699 cites W4211248568 @default.
• W3136074699 doi "https://doi.org/10.1016/j.humimm.2021.03.003" @default.
• W3136074699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33766427" @default.
• W3136074699 hasPublicationYear "2021" @default.
• W3136074699 type Work @default.
• W3136074699 sameAs 3136074699 @default.
• W3136074699 citedByCount "9" @default.
• W3136074699 countsByYear W31360746992021 @default.
• W3136074699 countsByYear W31360746992022 @default.
• W3136074699 countsByYear W31360746992023 @default.
• W3136074699 crossrefType "journal-article" @default.
• W3136074699 hasAuthorship W3136074699A5048445348 @default.
• W3136074699 hasAuthorship W3136074699A5072962826 @default.
• W3136074699 hasConcept C203014093 @default.
• W3136074699 hasConcept C2778690821 @default.
• W3136074699 hasConcept C2779635636 @default.
• W3136074699 hasConcept C533803919 @default.
• W3136074699 hasConcept C71924100 @default.
• W3136074699 hasConcept C86803240 @default.
• W3136074699 hasConcept C8891405 @default.
• W3136074699 hasConceptScore W3136074699C203014093 @default.
• W3136074699 hasConceptScore W3136074699C2778690821 @default.

• next