FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136075442> ?p ?o ?g. }

• W3136075442 endingPage "1291" @default.
• W3136075442 startingPage "1263" @default.
• W3136075442 abstract "The objective of this review was to determine the diagnostic accuracy of [-2]proPSA (p2PSA) and the Prostate Health Index compared to the Gleason score in determining the aggressiveness of prostate cancer.Prostate cancer is the most commonly diagnosed cancer in men. However, the utility of currently available biomarkers for determining the aggressive form of the disease remains unknown. This review sought to determine the diagnostic accuracy of two new biomarkers in determining the aggressive form of prostate cancer.Diagnostic accuracy studies that enrolled men of any age and any prostate specific antigen (PSA) level with histologically confirmed prostate cancer in which Prostate Health Index and p2PSA were assessed in comparison to Gleason score for the determination of aggressive prostate cancer were considered for inclusion. There was no time limitation on study inclusion.A three-step search strategy was utilized to identify both published and unpublished studies in the English language in the following sources: PubMed, Cochrane Central Register of Controlled Trials, CINAHL, Web of Science, Google Scholar, MedNar, and SIGLE. Databases were searched from inception to January 2019. Study selection, critical appraisal, data extraction, and data synthesis were done according to the approach recommended by JBI.A total of 12 studies (n = 8462) that recruited men with aggressive prostate cancer were considered in this review. The majority of included subjects had a total PSA level of 2 to 10ng/mL. The sensitivity of the Prostate Health Index ranged from 67% to 97% while specificity ranged from 6% to 64%. At a Prostate Health Index threshold of 25 and below (three studies, n = 3222), pooled sensitivity was 97% (95% confidence interval [CI], 95% to 98%) and specificity was 10% (95% CI, 6% to 16%). At a Prostate Health Index threshold of between 26 and 35 (six studies, n = 6030), pooled sensitivity was 87% (95% CI, 8% to 91%) and specificity was 45% (95% CI, 39% to 50%). At a Prostate Health Index threshold of 36 and above (five studies, n = 1476), pooled sensitivity was 72% (95% CI, 64% to 79%) and specificity was 74% (95% CI, 68% to 80%). Only one study assessed p2PSA. Sensitivity ranged from 80% to 95%, and specificity ranged from 9.9% to 27.9% with increasing threshold values from 7.9 to 10.9ng/mL.Overall, both Prostate Health Index and p2PSA have acceptable accuracy for the determination of the likelihood of aggressive prostate cancer. However, the inverse relationship between sensitivity and specificity makes it difficult to determine an optimum cut-off value for positivity. Further research is warranted to determine their utility in the management of prostate cancer." @default.
• W3136075442 created "2021-03-29" @default.
• W3136075442 creator A5010749328 @default.
• W3136075442 creator A5016852570 @default.
• W3136075442 creator A5037148746 @default.
• W3136075442 creator A5060786897 @default.
• W3136075442 date "2021-03-17" @default.
• W3136075442 modified "2023-10-16" @default.
• W3136075442 title "Diagnostic accuracy of [-2]proPSA versus Gleason score and Prostate Health Index versus Gleason score for the determination of aggressive prostate cancer: a systematic review" @default.
• W3136075442 cites W1487984827 @default.
• W3136075442 cites W1585611509 @default.
• W3136075442 cites W1757407923 @default.
• W3136075442 cites W1967456134 @default.
• W3136075442 cites W1969825763 @default.
• W3136075442 cites W1970876554 @default.
• W3136075442 cites W1971225393 @default.
• W3136075442 cites W1973482484 @default.
• W3136075442 cites W1978111804 @default.
• W3136075442 cites W1983219943 @default.
• W3136075442 cites W1986912270 @default.
• W3136075442 cites W1988864511 @default.
• W3136075442 cites W1994708097 @default.
• W3136075442 cites W1997356983 @default.
• W3136075442 cites W2003465402 @default.
• W3136075442 cites W2011332958 @default.
• W3136075442 cites W2020293070 @default.
• W3136075442 cites W2032359663 @default.
• W3136075442 cites W2033843156 @default.
• W3136075442 cites W2044385780 @default.
• W3136075442 cites W2054269513 @default.
• W3136075442 cites W2056426318 @default.
• W3136075442 cites W2071221115 @default.
• W3136075442 cites W2072315075 @default.
• W3136075442 cites W2073372361 @default.
• W3136075442 cites W2073521250 @default.
• W3136075442 cites W2081474318 @default.
• W3136075442 cites W2088978840 @default.
• W3136075442 cites W2103764347 @default.
• W3136075442 cites W2111089373 @default.
• W3136075442 cites W2111704207 @default.
• W3136075442 cites W2115441465 @default.
• W3136075442 cites W2120719882 @default.
• W3136075442 cites W2126157922 @default.
• W3136075442 cites W2136550229 @default.
• W3136075442 cites W2151523929 @default.
• W3136075442 cites W2161484910 @default.
• W3136075442 cites W2170552969 @default.
• W3136075442 cites W2195006090 @default.
• W3136075442 cites W2200543190 @default.
• W3136075442 cites W2220924064 @default.
• W3136075442 cites W2288230592 @default.
• W3136075442 cites W2293704657 @default.
• W3136075442 cites W2313566866 @default.
• W3136075442 cites W2319842284 @default.
• W3136075442 cites W2333563466 @default.
• W3136075442 cites W2334197964 @default.
• W3136075442 cites W2471854534 @default.
• W3136075442 cites W2508767114 @default.
• W3136075442 cites W2510939497 @default.
• W3136075442 cites W2531555178 @default.
• W3136075442 cites W2547167998 @default.
• W3136075442 cites W2555522697 @default.
• W3136075442 cites W2559014962 @default.
• W3136075442 cites W2565866108 @default.
• W3136075442 cites W2586531365 @default.
• W3136075442 cites W2601498065 @default.
• W3136075442 cites W2617782898 @default.
• W3136075442 cites W2731682278 @default.
• W3136075442 cites W2740270226 @default.
• W3136075442 cites W2748382959 @default.
• W3136075442 cites W2767464694 @default.
• W3136075442 cites W2771725048 @default.
• W3136075442 cites W2789262688 @default.
• W3136075442 cites W2792740577 @default.
• W3136075442 cites W2793689913 @default.
• W3136075442 cites W2796467050 @default.
• W3136075442 cites W2807974757 @default.
• W3136075442 cites W2884014904 @default.
• W3136075442 cites W2884987582 @default.
• W3136075442 cites W4244945083 @default.
• W3136075442 cites W4294215472 @default.
• W3136075442 doi "https://doi.org/10.11124/jbisrir-d-19-00194" @default.
• W3136075442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33741840" @default.
• W3136075442 hasPublicationYear "2021" @default.
• W3136075442 type Work @default.
• W3136075442 sameAs 3136075442 @default.
• W3136075442 citedByCount "0" @default.
• W3136075442 crossrefType "journal-article" @default.
• W3136075442 hasAuthorship W3136075442A5010749328 @default.
• W3136075442 hasAuthorship W3136075442A5016852570 @default.
• W3136075442 hasAuthorship W3136075442A5037148746 @default.
• W3136075442 hasAuthorship W3136075442A5060786897 @default.
• W3136075442 hasBestOaLocation W31360754421 @default.
• W3136075442 hasConcept C118552586 @default.
• W3136075442 hasConcept C121608353 @default.
• W3136075442 hasConcept C126322002 @default.
• W3136075442 hasConcept C142724271 @default.
• W3136075442 hasConcept C143998085 @default.

• next