Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136078809> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W3136078809 endingPage "1471" @default.
- W3136078809 startingPage "1460" @default.
- W3136078809 abstract "Mild to moderate bleeding disorders are a diagnostic challenge. Many patients remain undiagnosed despite thorough and repeated laboratory testing. Thrombin generation (TG) is an overall assay measuring the functionality of the hemostatic system and may be a useful tool in diagnosing patients with bleeding tendency.We examined the added value of TG in patients with mild bleeding tendency with and without diagnosis after classical laboratory testing. Further, we investigated the role of different expressions of results, between-method variation, and reference ranges.TG of patients and controls was measured in parallel by two TG platforms (ST Genesia and calibrated automated thrombogram [CAT]). All TG parameters in patient and control groups were compared by statistical analysis (Mann-Whitney U tests) including visual representation with box-and-whisker plots. Results were expressed as normalized ratios (ST Genesia and CAT) or corrected values (ST Genesia). Reference intervals were calculated to which patient results were compared. We studied lot-to-lot reagent variability for both platforms.In 62.7% (ST Genesia) to 69.5% (CAT) of patients undiagnosed with a traditional laboratory work-up, abnormal TG parameters (lag time and endogenous thrombin potential expressed as normalized ratio and/or corrected value) were detected. In the group of previously diagnosed patients, abnormal parameters were found in 58.1% of patients for both TG assays. No relevant lot-to-lot reagent variability was observed.Adding TG helps with diagnosing patients with mild bleeding disorder. TG seems a promising tool in diagnosis of bleeding tendency, but further evaluation is necessary before application in diagnostic laboratory testing." @default.
- W3136078809 created "2021-03-29" @default.
- W3136078809 creator A5040611296 @default.
- W3136078809 creator A5056763738 @default.
- W3136078809 creator A5068949684 @default.
- W3136078809 creator A5071705224 @default.
- W3136078809 date "2021-06-01" @default.
- W3136078809 modified "2023-10-12" @default.
- W3136078809 title "Thrombin generation measured by two platforms in patients with a bleeding tendency" @default.
- W3136078809 cites W1505239733 @default.
- W3136078809 cites W1963731836 @default.
- W3136078809 cites W1971375546 @default.
- W3136078809 cites W1973687787 @default.
- W3136078809 cites W1989503911 @default.
- W3136078809 cites W2022828223 @default.
- W3136078809 cites W2031847335 @default.
- W3136078809 cites W2051150132 @default.
- W3136078809 cites W2060090185 @default.
- W3136078809 cites W2076636814 @default.
- W3136078809 cites W2085433233 @default.
- W3136078809 cites W2087879607 @default.
- W3136078809 cites W2096306307 @default.
- W3136078809 cites W2114246103 @default.
- W3136078809 cites W2119768870 @default.
- W3136078809 cites W2120037305 @default.
- W3136078809 cites W2130801240 @default.
- W3136078809 cites W2134656911 @default.
- W3136078809 cites W2171630863 @default.
- W3136078809 cites W2293439019 @default.
- W3136078809 cites W2398829893 @default.
- W3136078809 cites W2612674059 @default.
- W3136078809 cites W2799641449 @default.
- W3136078809 cites W2903909082 @default.
- W3136078809 cites W2937401573 @default.
- W3136078809 cites W2944304799 @default.
- W3136078809 cites W2962781082 @default.
- W3136078809 cites W3016752843 @default.
- W3136078809 cites W3036777711 @default.
- W3136078809 doi "https://doi.org/10.1111/jth.15292" @default.
- W3136078809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34668300" @default.
- W3136078809 hasPublicationYear "2021" @default.
- W3136078809 type Work @default.
- W3136078809 sameAs 3136078809 @default.
- W3136078809 citedByCount "9" @default.
- W3136078809 countsByYear W31360788092021 @default.
- W3136078809 countsByYear W31360788092022 @default.
- W3136078809 countsByYear W31360788092023 @default.
- W3136078809 crossrefType "journal-article" @default.
- W3136078809 hasAuthorship W3136078809A5040611296 @default.
- W3136078809 hasAuthorship W3136078809A5056763738 @default.
- W3136078809 hasAuthorship W3136078809A5068949684 @default.
- W3136078809 hasAuthorship W3136078809A5071705224 @default.
- W3136078809 hasBestOaLocation W31360788091 @default.
- W3136078809 hasConcept C126322002 @default.
- W3136078809 hasConcept C141071460 @default.
- W3136078809 hasConcept C164705383 @default.
- W3136078809 hasConcept C2777292125 @default.
- W3136078809 hasConcept C3018972837 @default.
- W3136078809 hasConcept C71924100 @default.
- W3136078809 hasConcept C89560881 @default.
- W3136078809 hasConcept C90924648 @default.
- W3136078809 hasConceptScore W3136078809C126322002 @default.
- W3136078809 hasConceptScore W3136078809C141071460 @default.
- W3136078809 hasConceptScore W3136078809C164705383 @default.
- W3136078809 hasConceptScore W3136078809C2777292125 @default.
- W3136078809 hasConceptScore W3136078809C3018972837 @default.
- W3136078809 hasConceptScore W3136078809C71924100 @default.
- W3136078809 hasConceptScore W3136078809C89560881 @default.
- W3136078809 hasConceptScore W3136078809C90924648 @default.
- W3136078809 hasIssue "6" @default.
- W3136078809 hasLocation W31360788091 @default.
- W3136078809 hasLocation W31360788092 @default.
- W3136078809 hasOpenAccess W3136078809 @default.
- W3136078809 hasPrimaryLocation W31360788091 @default.
- W3136078809 hasRelatedWork W1489399279 @default.
- W3136078809 hasRelatedWork W1836976275 @default.
- W3136078809 hasRelatedWork W1972859004 @default.
- W3136078809 hasRelatedWork W1973687787 @default.
- W3136078809 hasRelatedWork W2014352220 @default.
- W3136078809 hasRelatedWork W2274642994 @default.
- W3136078809 hasRelatedWork W2399776670 @default.
- W3136078809 hasRelatedWork W2417206646 @default.
- W3136078809 hasRelatedWork W2427949989 @default.
- W3136078809 hasRelatedWork W4302560895 @default.
- W3136078809 hasVolume "19" @default.
- W3136078809 isParatext "false" @default.
- W3136078809 isRetracted "false" @default.
- W3136078809 magId "3136078809" @default.
- W3136078809 workType "article" @default.