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• W3136100188 startingPage "1675" @default.
• W3136100188 abstract "The compound 4-dihydroxyboryl-l-phenylalanine (BPA) has found use in clinical trials of boron neutron capture therapy (BNCT). Here, we have examined the interaction with DNA of an amide-blocked BPA derivative of hexa-l-arginine (Ac-BPA-Arg6-NH2). Physical and spectroscopic assays show that this peptide binds to and condenses DNA. The resulting condensates are highly resistant to the effects of nuclease incubation (68-fold) and gamma (38-fold) irradiation. Radioprotection was modeled by Monte Carlo track structure simulations of DNA single strand breaks (SSBs) with TOPAS-nBio. The differences between experimental and simulated SSB yields for uncondensed and condensed DNAs were ca. 2 and 18%, respectively. These observations indicate that the combination of a plasmid DNA target, the BPA-containing peptide, and track structure simulation provides a powerful approach to characterize DNA damage by the high-LET radiation associated with neutron capture on boron." @default.
• W3136100188 created "2021-03-29" @default.
• W3136100188 creator A5002358311 @default.
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• W3136100188 date "2021-03-22" @default.
• W3136100188 modified "2023-10-17" @default.
• W3136100188 title "Boronated Condensed DNA as a Heterochromatic Radiation Target Model" @default.
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• W3136100188 doi "https://doi.org/10.1021/acs.biomac.1c00106" @default.
• W3136100188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33750108" @default.
• W3136100188 hasPublicationYear "2021" @default.
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