Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136100821> ?p ?o ?g. }
- W3136100821 endingPage "1248" @default.
- W3136100821 startingPage "1235" @default.
- W3136100821 abstract "Cyclic GMP-AMP synthase (cGAS), a key sensor of intracellular DNA, is essential for eliciting innate immunity against infection, whereas aberrant activation of cGAS by endogenous DNA promotes severe autoimmune diseases. However, it is largely unknown how cGAS expression is regulated during pathogen infection and autoimmunity. Here, we report that during herpes simplex virus type 1 (HSV-1) infection, two microRNAs (miR-23a and miR-23b) whose levels significantly decrease due to their interaction with the lncRNA Oasl2-209 directly regulate the expression of cGAS. Overexpression of miR-23a/b markedly dampens cytosolic DNA-induced innate immune responses, whereas inhibition of miR-23a/b enhances these responses. Mice treated with miR-23a/b agomirs exhibit increased susceptibility to HSV-1 infection. Moreover, cGAS is significantly upregulated in the Trex1-/- mouse autoimmune disease model. Administration of miR-23a/b blunts self DNA-induced autoinflammatory responses in Trex1-/- mice. Collectively, our study not only reveals a novel regulatory mechanism of cGAS expression by miRNAs but also identifies a potential therapy for cGAS-related autoimmune diseases." @default.
- W3136100821 created "2021-03-29" @default.
- W3136100821 creator A5010496720 @default.
- W3136100821 creator A5013038112 @default.
- W3136100821 creator A5042560699 @default.
- W3136100821 creator A5053047432 @default.
- W3136100821 creator A5070317068 @default.
- W3136100821 creator A5076373378 @default.
- W3136100821 creator A5091629317 @default.
- W3136100821 date "2021-03-25" @default.
- W3136100821 modified "2023-10-16" @default.
- W3136100821 title "miR-23a/b suppress cGAS-mediated innate and autoimmunity" @default.
- W3136100821 cites W1559117436 @default.
- W3136100821 cites W1594574415 @default.
- W3136100821 cites W1857174086 @default.
- W3136100821 cites W1929156901 @default.
- W3136100821 cites W1975437957 @default.
- W3136100821 cites W1980923315 @default.
- W3136100821 cites W1988740302 @default.
- W3136100821 cites W1993375838 @default.
- W3136100821 cites W1997069349 @default.
- W3136100821 cites W2004714113 @default.
- W3136100821 cites W2012463451 @default.
- W3136100821 cites W2024733002 @default.
- W3136100821 cites W2042433863 @default.
- W3136100821 cites W2060004514 @default.
- W3136100821 cites W2068275410 @default.
- W3136100821 cites W2075264446 @default.
- W3136100821 cites W2076690763 @default.
- W3136100821 cites W2080503329 @default.
- W3136100821 cites W2083147016 @default.
- W3136100821 cites W2091114810 @default.
- W3136100821 cites W2099610218 @default.
- W3136100821 cites W2111585311 @default.
- W3136100821 cites W2117391818 @default.
- W3136100821 cites W2123645680 @default.
- W3136100821 cites W2145812105 @default.
- W3136100821 cites W2147701649 @default.
- W3136100821 cites W2156066970 @default.
- W3136100821 cites W2161227864 @default.
- W3136100821 cites W2170688212 @default.
- W3136100821 cites W2171946670 @default.
- W3136100821 cites W2263197327 @default.
- W3136100821 cites W2268476648 @default.
- W3136100821 cites W2520054346 @default.
- W3136100821 cites W2560080983 @default.
- W3136100821 cites W2566200459 @default.
- W3136100821 cites W2571604033 @default.
- W3136100821 cites W2580868078 @default.
- W3136100821 cites W2618634776 @default.
- W3136100821 cites W2742007963 @default.
- W3136100821 cites W2755550738 @default.
- W3136100821 cites W2759921274 @default.
- W3136100821 cites W2762611634 @default.
- W3136100821 cites W2801610489 @default.
- W3136100821 cites W2803376047 @default.
- W3136100821 cites W2854081253 @default.
- W3136100821 cites W2913251892 @default.
- W3136100821 cites W2916717448 @default.
- W3136100821 cites W2916844040 @default.
- W3136100821 cites W2922120784 @default.
- W3136100821 cites W2972890624 @default.
- W3136100821 cites W2990429902 @default.
- W3136100821 cites W2994834355 @default.
- W3136100821 cites W3024191006 @default.
- W3136100821 cites W3025075911 @default.
- W3136100821 doi "https://doi.org/10.1038/s41423-021-00668-x" @default.
- W3136100821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8093233" @default.
- W3136100821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33767433" @default.
- W3136100821 hasPublicationYear "2021" @default.
- W3136100821 type Work @default.
- W3136100821 sameAs 3136100821 @default.
- W3136100821 citedByCount "14" @default.
- W3136100821 countsByYear W31361008212021 @default.
- W3136100821 countsByYear W31361008212022 @default.
- W3136100821 countsByYear W31361008212023 @default.
- W3136100821 crossrefType "journal-article" @default.
- W3136100821 hasAuthorship W3136100821A5010496720 @default.
- W3136100821 hasAuthorship W3136100821A5013038112 @default.
- W3136100821 hasAuthorship W3136100821A5042560699 @default.
- W3136100821 hasAuthorship W3136100821A5053047432 @default.
- W3136100821 hasAuthorship W3136100821A5070317068 @default.
- W3136100821 hasAuthorship W3136100821A5076373378 @default.
- W3136100821 hasAuthorship W3136100821A5091629317 @default.
- W3136100821 hasBestOaLocation W31361008211 @default.
- W3136100821 hasConcept C104317684 @default.
- W3136100821 hasConcept C127561419 @default.
- W3136100821 hasConcept C136449434 @default.
- W3136100821 hasConcept C145059251 @default.
- W3136100821 hasConcept C203014093 @default.
- W3136100821 hasConcept C2522874641 @default.
- W3136100821 hasConcept C2779341262 @default.
- W3136100821 hasConcept C2780130043 @default.
- W3136100821 hasConcept C2781196997 @default.
- W3136100821 hasConcept C54355233 @default.
- W3136100821 hasConcept C79879829 @default.
- W3136100821 hasConcept C86803240 @default.
- W3136100821 hasConcept C8891405 @default.