FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136101070> ?p ?o ?g. }

• W3136101070 abstract "Introduction: Cerebral vasospasm (CV) following aneurysmal subarachnoid hemorrhage (aSAH) is associated with a high degree of morbidity and mortality. In an adequate oxidative environment, certain products of bilirubin metabolism have been hypothesized to be a cause of CV. To our knowledge no prospective CSF collection has been performed to establish a time course for their formation in the clinical context of CV. We aimed to design a pilot study assessing the feasibility of collecting and storing CSF for analysis of potential biochemical markers for CV, and to evaluate which variables can accurately and reliably be measured for a larger prospective study. Methods: Adult patients with aSAH and an external ventricular drain (EVD) were enrolled. Patients who had complications following treatment of aSAH or who developed any neurological deterioration unrelated to the aSAH were excluded. CSF was extracted from patients on the initial day of EVD placement and then daily for a total of 10 days and frozen until data analysis. Heme, Heme Oxygenase (HO-1) and Cu/Zn-Superoxide Dismutase (SOD) were measured using commercially available assay kits. Results: Patients 1, 2 and 3 had modified Fisher grades of 2, 3 and 4, respectively. Patients 1 and 3 underwent endovascular coiling and patient 2 had surgical clipping. There were no complications and no CV. Heme concentrations were 40.0 ± 8.5 μm, 55.6 ± 7.7 μm, and 64.7 ± 0.4 μm on day of bleed (day 0) for patients 1, 2, and 3, respectively, and decreased in patients 1 and 2 on day 1. SOD concentrations peaked on day 2 for patient 1 (140.2 ± 15.6 ng/mL), on day 0 for patient 2 (25.8 ± 14.9 ng/mL), and on day 1 for patient 3 (215.9 ± 24.4 ng/mL). HO-1 concentrations peaked for all three patients on day 2 (14.6 ± 0.4, 17.6 ± 12.0 and 23.6 ± 5.4 ng/mL, respectively). Conclusions: The study was successful in completing our objective of establishing a protocol for collection, storage, and measurement of three potential biochemical markers in CSF. A larger prospective study will be performed to establish the time course of bilirubin metabolism and oxidation in the CSF relative to the clinical condition of CV in patients after aSAH." @default.
• W3136101070 created "2021-03-29" @default.
• W3136101070 creator A5018078038 @default.
• W3136101070 creator A5033501751 @default.
• W3136101070 creator A5033655360 @default.
• W3136101070 creator A5034282536 @default.
• W3136101070 creator A5052353170 @default.
• W3136101070 creator A5080206898 @default.
• W3136101070 date "2021-03-01" @default.
• W3136101070 modified "2023-10-18" @default.
• W3136101070 title "Abstract P756: Bilirubin Oxidation and Cerebral Vasospasm in Subarachnoid Hemorrhage: A Feasibility Study" @default.
• W3136101070 doi "https://doi.org/10.1161/str.52.suppl_1.p756" @default.
• W3136101070 hasPublicationYear "2021" @default.
• W3136101070 type Work @default.
• W3136101070 sameAs 3136101070 @default.
• W3136101070 citedByCount "0" @default.
• W3136101070 crossrefType "journal-article" @default.
• W3136101070 hasAuthorship W3136101070A5018078038 @default.
• W3136101070 hasAuthorship W3136101070A5033501751 @default.
• W3136101070 hasAuthorship W3136101070A5033655360 @default.
• W3136101070 hasAuthorship W3136101070A5034282536 @default.
• W3136101070 hasAuthorship W3136101070A5052353170 @default.
• W3136101070 hasAuthorship W3136101070A5080206898 @default.
• W3136101070 hasConcept C126322002 @default.
• W3136101070 hasConcept C141071460 @default.
• W3136101070 hasConcept C151730666 @default.
• W3136101070 hasConcept C188816634 @default.
• W3136101070 hasConcept C2776259030 @default.
• W3136101070 hasConcept C2776820941 @default.
• W3136101070 hasConcept C2777094939 @default.
• W3136101070 hasConcept C2777513400 @default.
• W3136101070 hasConcept C2777736543 @default.
• W3136101070 hasConcept C2778506911 @default.
• W3136101070 hasConcept C2779343474 @default.
• W3136101070 hasConcept C42219234 @default.
• W3136101070 hasConcept C71924100 @default.
• W3136101070 hasConcept C86803240 @default.
• W3136101070 hasConceptScore W3136101070C126322002 @default.
• W3136101070 hasConceptScore W3136101070C141071460 @default.
• W3136101070 hasConceptScore W3136101070C151730666 @default.
• W3136101070 hasConceptScore W3136101070C188816634 @default.
• W3136101070 hasConceptScore W3136101070C2776259030 @default.
• W3136101070 hasConceptScore W3136101070C2776820941 @default.
• W3136101070 hasConceptScore W3136101070C2777094939 @default.
• W3136101070 hasConceptScore W3136101070C2777513400 @default.
• W3136101070 hasConceptScore W3136101070C2777736543 @default.
• W3136101070 hasConceptScore W3136101070C2778506911 @default.
• W3136101070 hasConceptScore W3136101070C2779343474 @default.
• W3136101070 hasConceptScore W3136101070C42219234 @default.
• W3136101070 hasConceptScore W3136101070C71924100 @default.
• W3136101070 hasConceptScore W3136101070C86803240 @default.
• W3136101070 hasIssue "Suppl_1" @default.
• W3136101070 hasLocation W31361010701 @default.
• W3136101070 hasOpenAccess W3136101070 @default.
• W3136101070 hasPrimaryLocation W31361010701 @default.
• W3136101070 hasRelatedWork W1534827720 @default.
• W3136101070 hasRelatedWork W1951980777 @default.
• W3136101070 hasRelatedWork W1974855968 @default.
• W3136101070 hasRelatedWork W1990794882 @default.
• W3136101070 hasRelatedWork W2006872818 @default.
• W3136101070 hasRelatedWork W2015503583 @default.
• W3136101070 hasRelatedWork W2115785602 @default.
• W3136101070 hasRelatedWork W2885340870 @default.
• W3136101070 hasRelatedWork W3136101070 @default.
• W3136101070 hasRelatedWork W4210753068 @default.
• W3136101070 hasVolume "52" @default.
• W3136101070 isParatext "false" @default.
• W3136101070 isRetracted "false" @default.
• W3136101070 magId "3136101070" @default.
• W3136101070 workType "article" @default.