Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136102477> ?p ?o ?g. }
- W3136102477 endingPage "119" @default.
- W3136102477 startingPage "108" @default.
- W3136102477 abstract "Mutations in the genes coding for tryptophan-hydrolase-2 and the scaffold protein FKBP5 are associated with an increased risk of suicide. The mutation in both cases enhances the enzymatic activity of glycogen synthase kinase-3 (GSK3). Conversely, anti-suicidal medications, such as lithium, clozapine, and ketamine, indirectly inhibit the activity of GSK3. When GSK3 is active, it promotes the metabolic removal of the transcription factor NRF2 (nuclear factor erythroid 2-related factor-2), which suppresses the transcription of multiple genes that encode anti-oxidative and anti-inflammatory proteins. Notably, several suicide-biomarkers bear witness to an ongoing inflammatory process. Moreover, alterations in serum lipid levels measured in suicidal individuals are mirrored by data obtained in mice with genetic deletion of the NRF2 gene. Inflammation is presumably causally related to both dysphoria and anger, two factors relevant for suicide ideation and attempt. Preventing the catabolism of NRF2 could be a strategy to obtain novel suicide-prophylactic medications. Possible candidates are minocycline and nicotinic-α7 agonists. The antibiotic minocycline indirectly activates NRF2-transcriptional activity, whereas the activation of nicotinic-α7 receptors indirectly inhibits GSK3." @default.
- W3136102477 created "2021-03-29" @default.
- W3136102477 creator A5032330352 @default.
- W3136102477 date "2021-03-21" @default.
- W3136102477 modified "2023-09-25" @default.
- W3136102477 title "The GSK3-NRF2 Axis in Suicide" @default.
- W3136102477 cites W1575385540 @default.
- W3136102477 cites W1589025210 @default.
- W3136102477 cites W1771262887 @default.
- W3136102477 cites W1800932169 @default.
- W3136102477 cites W1816875290 @default.
- W3136102477 cites W1893670457 @default.
- W3136102477 cites W1963440759 @default.
- W3136102477 cites W1968764187 @default.
- W3136102477 cites W1970155580 @default.
- W3136102477 cites W1970816180 @default.
- W3136102477 cites W1976396510 @default.
- W3136102477 cites W1976955283 @default.
- W3136102477 cites W1977170154 @default.
- W3136102477 cites W1977676880 @default.
- W3136102477 cites W1995120027 @default.
- W3136102477 cites W1995274749 @default.
- W3136102477 cites W1995630168 @default.
- W3136102477 cites W1999121442 @default.
- W3136102477 cites W1999148207 @default.
- W3136102477 cites W1999468411 @default.
- W3136102477 cites W1999600703 @default.
- W3136102477 cites W2006940628 @default.
- W3136102477 cites W2011668019 @default.
- W3136102477 cites W2013689853 @default.
- W3136102477 cites W2015928690 @default.
- W3136102477 cites W2016278859 @default.
- W3136102477 cites W2017149290 @default.
- W3136102477 cites W2018529141 @default.
- W3136102477 cites W2019203176 @default.
- W3136102477 cites W2021763195 @default.
- W3136102477 cites W2025330029 @default.
- W3136102477 cites W2035360924 @default.
- W3136102477 cites W2038084705 @default.
- W3136102477 cites W2040894493 @default.
- W3136102477 cites W2041013746 @default.
- W3136102477 cites W2043313558 @default.
- W3136102477 cites W2045821670 @default.
- W3136102477 cites W2048881476 @default.
- W3136102477 cites W2061711185 @default.
- W3136102477 cites W2063682731 @default.
- W3136102477 cites W2063897784 @default.
- W3136102477 cites W2064150110 @default.
- W3136102477 cites W2066248256 @default.
- W3136102477 cites W2068205986 @default.
- W3136102477 cites W2072920261 @default.
- W3136102477 cites W2073707788 @default.
- W3136102477 cites W2076368041 @default.
- W3136102477 cites W2081102171 @default.
- W3136102477 cites W2089638277 @default.
- W3136102477 cites W2091945251 @default.
- W3136102477 cites W2094177807 @default.
- W3136102477 cites W2094976308 @default.
- W3136102477 cites W2097183790 @default.
- W3136102477 cites W2100654304 @default.
- W3136102477 cites W2102636814 @default.
- W3136102477 cites W2103232698 @default.
- W3136102477 cites W2104536121 @default.
- W3136102477 cites W2107492660 @default.
- W3136102477 cites W2115679410 @default.
- W3136102477 cites W2116194465 @default.
- W3136102477 cites W2117178110 @default.
- W3136102477 cites W2117800935 @default.
- W3136102477 cites W2118394016 @default.
- W3136102477 cites W2118815581 @default.
- W3136102477 cites W2120306544 @default.
- W3136102477 cites W2121242600 @default.
- W3136102477 cites W2121304943 @default.
- W3136102477 cites W2126795224 @default.
- W3136102477 cites W2127119869 @default.
- W3136102477 cites W2131964197 @default.
- W3136102477 cites W2133961780 @default.
- W3136102477 cites W2137625559 @default.
- W3136102477 cites W2138517367 @default.
- W3136102477 cites W2140793441 @default.
- W3136102477 cites W2142470720 @default.
- W3136102477 cites W2144565283 @default.
- W3136102477 cites W2146249230 @default.
- W3136102477 cites W2147984935 @default.
- W3136102477 cites W2151740555 @default.
- W3136102477 cites W2156083049 @default.
- W3136102477 cites W2156381640 @default.
- W3136102477 cites W2158113210 @default.
- W3136102477 cites W2159304116 @default.
- W3136102477 cites W2161793782 @default.
- W3136102477 cites W2161963246 @default.
- W3136102477 cites W2164393748 @default.
- W3136102477 cites W2165500341 @default.
- W3136102477 cites W2166945572 @default.
- W3136102477 cites W2167112221 @default.
- W3136102477 cites W2182110160 @default.
- W3136102477 cites W2192559277 @default.
- W3136102477 cites W2201065648 @default.