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- W3136109176 abstract "Benzodiazepines are commonly used to treat disorders of the central nervous system, including anxiety. However, due to their adverse effects, there is a continuing interest in discovering new safe and effective drugs. Marine natural products have emerged as a prolific source of bioactive nitrogenated compounds. Aiming to discover new biologically active natural compounds, the marine sponge Aplysina fulva , a nitrogen-bearing heterocyst producer, was investigated. The main isolated compounds ( 4 , 6 , and 9 ) were evaluated on adult zebrafish ( Danio rerio ). A group of fishes (n = 6) was preliminarily subjected to acute toxicity, and open field tests using 0.1, 0.5, and 1.0 mg/mL ( v. o. ) of those compounds was performed. The anxiolytic effect was further investigated in the light/dark assay based on the locomotor response at zebrafish. Interactions through the GABAergic system were investigated using flumazenil, a silent modulator of GABA receptors. To improve the results, a study of molecular docking using the GABAA receptor also was performed. Based on the results, the bromotyrosine derivative compounds 4 , 6 , and 9 exhibited anxiolytic-like effects mediated by the GABAergic system. • The isolated compounds from Aplysina fulva ( 4 , 6 , and 9 ) showed no toxicity and reduced locomotor activity in adult zebrafish. • The compounds showed an anxiolytic-like effect in adult zebrafish. • The anxiolytic effect was modulated via the GABAergic system. • The molecular docking study corroborated the anxiolytic effect via GABA A receptor." @default.
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- W3136109176 date "2021-06-01" @default.
- W3136109176 modified "2023-09-27" @default.
- W3136109176 title "Anxiolytic-like effect of brominated compounds from the marine sponge Aplysina fulva on adult zebrafish (Danio rerio): Involvement of the GABAergic system" @default.
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- W3136109176 doi "https://doi.org/10.1016/j.neuint.2021.105021" @default.
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