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- W3136113210 endingPage "113379" @default.
- W3136113210 startingPage "113379" @default.
- W3136113210 abstract "Emerging evidence suggests that cancer metabolism is closely associated to the serine biosynthesis pathway (SSP), in which glycolytic intermediate 3-phosphoglycerate is converted to serine through a three-step enzymatic transformation. As the rate-limiting enzyme in the first step of SSP, phosphoglycerate dehydrogenase (PHGDH) is overexpressed in various diseases, especially in cancer. Genetic knockdown or silencing of PHGDH exhibits obvious anti-tumor response both in vitro and in vivo, demonstrating that PHGDH is a promising drug target for cancer therapy. So far, several types of PHGDH inhibitors have been identified as a significant and newly emerging option for anticancer treatment. Herein, this comprehensive review summarizes the recent achievements of PHGDH, especially its critical role in cancer and the development of PHGDH inhibitors in drug discovery." @default.
- W3136113210 created "2021-03-29" @default.
- W3136113210 creator A5006247366 @default.
- W3136113210 creator A5006264629 @default.
- W3136113210 creator A5016112062 @default.
- W3136113210 creator A5020012787 @default.
- W3136113210 creator A5023443985 @default.
- W3136113210 creator A5038580778 @default.
- W3136113210 creator A5063909737 @default.
- W3136113210 creator A5066235983 @default.
- W3136113210 date "2021-05-01" @default.
- W3136113210 modified "2023-10-16" @default.
- W3136113210 title "A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism" @default.
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