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- W3136120216 startingPage "3312" @default.
- W3136120216 abstract "The proper expression of gonadotropin-releasing hormone receptors (GnRHRs) by pituitary gonadotropes is critical for maintaining maximum reproductive capacity. GnRH receptor expression must be tightly regulated in order to maintain the normal pattern of expression through the estrous cycle in rodents, which is believed to be important for interpreting the finely tuned pulses of GnRH from the hypothalamus. Much work has shown that Gnrhr expression is heavily regulated at the level of transcription. However, researchers have also discovered that Gnrhr is regulated post-transcriptionally. This review will discuss how RNA-binding proteins and microRNAs may play critical roles in the regulation of GnRHR expression. We will also discuss how these post-transcriptional regulators may themselves be affected by metabolic cues, specifically with regards to the adipokine leptin. All together, we present evidence that Gnrhr is regulated post-transcriptionally, and that this concept must be further explored in order to fully understand the complex nature of this receptor." @default.
- W3136120216 created "2021-03-29" @default.
- W3136120216 creator A5023815811 @default.
- W3136120216 creator A5036013287 @default.
- W3136120216 creator A5037772198 @default.
- W3136120216 creator A5047232306 @default.
- W3136120216 date "2021-03-24" @default.
- W3136120216 modified "2023-10-14" @default.
- W3136120216 title "Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction" @default.
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