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W3136122532 abstract "Ăvod: MetabolickĂ˝ syndrom patĹĂ mezi zĂĄvaĹžnĂ˝ celosvÄtovĂ˝ spoleÄenskĂ˝ problĂŠm. V ÄeskĂŠ republice trpĂ tĂmto onemocnÄnĂm vĂce neĹž 30 % dospÄlĂŠ populace. Role rekurentnĂ akutnĂ pankreatitidy v indukci pankreatitidy chronickĂŠ, ve shodÄ s mechanistickou definicĂ chronickĂŠ pankreatitidy, byla jednoznaÄnÄ potvrzena. Existuje vĹĄak Ĺada faktorĹŻ, kterĂŠ mohou pĹispÄt k rozvoji chronickĂŠ pankreatitidy. PrvnĂm cĂlem studie bylo zjistit, zda metabolickĂ˝ syndrom mĹŻĹže mĂt vliv na rozvoj chronickĂŠ pankreatitidy. Druhou otĂĄzku jsme si poloĹžili, zda i jedna prodÄlanĂĄ ataka pankreatitidy akutnĂ, mĹŻĹže bĂ˝t vyvolĂĄvajĂcĂ faktor pankreatitidy chronickĂŠ. Metody: Na zĂĄkladÄ retrospektivnÄ zĂskanĂ˝ch dat celkem od 264 osob, kterĂŠ jsou dispenzarizovĂĄny s diagnĂłzou chronickĂŠ pankreatitidy ve 4 centrech, byl zĂskĂĄn soubor celkem 59 osob (22,3 %) s chronickou pankreatitidou diagnostikovanou do 36 mÄsĂcĹŻ od prvĂŠ ataky pankreatitidy akutnĂ. VylouÄena byla etiologie pankreatitidy geneticky indukovanĂŠ a pankreatitidy autoimunitnĂ. Ze zĂskanĂŠho souboru 59 osob byla provedena diagnostika metabolickĂŠho syndromu na zĂĄkladÄ splnÄnĂ kritĂŠriĂ tzv. harmonizovanĂŠ definice z roku 2009 (obezita, arteriĂĄlnĂ hypertenze, hypertriglyceridĂŠmie, diabetes mellitus 2. typu a snĂĹženĂĄ hladina HDL cholesterolu). VĂ˝sledky: PĹi porovnĂĄnĂ nĂĄlezĹŻ jednotlivĂ˝ch komponent metabolickĂŠho syndromu u osob s chronickou pankreatitidou po 1. atace akutnĂ pankreatitidy s metabolickĂ˝m syndromem a u osob s chronickou pankreatitidou po 1. atace akutnĂ pankreatitidy bez metabolickĂŠho syndromu, byl nalezen statisticky vĂ˝znamnĂ˝ rozdĂl v zastoupenĂ obezity (82,5 % v.s. 28,5 %), hypertriglyceridĂŠmie (82,3 % v.s. 17,8 %) a arteriĂĄlnĂ hypertenze (70,5 % v.s. 21,4 %). Interval, bÄhem kterĂŠho doĹĄlo ke vzniku chronickĂŠ pankreatitidy po akutnĂ pankreatitidÄ, u osob s metabolickĂ˝m syndromem Äinila prĹŻmÄrnĂĄ doba 12 mÄsĂcĹŻ (10-14 mÄsĂcĹŻ), zatĂmco u skupiny bez pĹĂtomnosti metabolickĂŠho syndromu byl ÄasovĂ˝ interval delĹĄĂ, Äinil 20 mÄsĂcĹŻ (16-29 mÄsĂcĹŻ). ZĂĄvÄr: NaĹĄe vĂ˝sledky ukazujĂ, Ĺže i jedna ataka akutnĂ pankreatitidy (bez ohledu na etiologii), mĹŻĹže bĂ˝t vyvolĂĄvajĂcĂm faktorem pankreatitidy chronickĂŠ. PĹĂtomnost metabolickĂŠho syndromu mĹŻĹže akcelerovat rozvoj chronickĂŠ pankreatitidy po prodÄlanĂŠ pankreatitidÄ akutnĂ." @default.
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W3136122532 date "2020-12-15" @default.
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W3136122532 title "The role of metabolic syndrome in the induction of chronic pancreatitis after a first attack of acute pancreatitis - multicenter trial" @default.
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W3136122532 doi "https://doi.org/10.36290/vnl.2020.152" @default.
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