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- W3136123755 abstract "Cellular life depends on transport and communication across membranes, which is emphasized by the fact that membrane proteins are prime drug targets. The cell-like environment of membrane proteins has gained increasing attention based on its important role in function and regulation. As a versatile scaffold for bottom-up synthetic biology and nanoscience, giant liposomes represent minimalistic models of living cells. Nevertheless, the incorporation of fragile multiprotein membrane complexes still remains a major challenge. Here, we report on an approach for the functional reconstitution of membrane assemblies exemplified by human and bacterial ATP-binding cassette (ABC) transporters. We reveal that these nanomachineries transport substrates unidirectionally against a steep concentration gradient. Active substrate transport can be spatiotemporally resolved in single cell-like compartments by light, enabling real-time tracking of substrate export and import in individual liposomes. This approach will help to construct delicate artificial cell-like systems." @default.
- W3136123755 created "2021-03-29" @default.
- W3136123755 creator A5007668889 @default.
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- W3136123755 date "2021-03-16" @default.
- W3136123755 modified "2023-09-24" @default.
- W3136123755 title "Single Cell-like Systems Reveal Active Unidirectional and Light-Controlled Transport by Nanomachineries" @default.
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- W3136123755 doi "https://doi.org/10.1021/acsnano.0c10139" @default.
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