Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136124560> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3136124560 abstract "Dietary terpenes have not been studied enough, despite the fact that they are absorbed well and display a range of biological properties. Better knowledge about their metabolism will help understanding the health effects of plant foods, herbs and spices and may provide new biomarkers of food intake. As part of the FoodBAll project we are investigating the metabolism of terpenes, identifying metabolites and biotransformations involved in their metabolism. PhytoHub (database that compiles all known metabolites of dietary phytochemicals, including terpenes) and Nexus Meteor (in silico prediction of metabolism), were used to identify biotransformations involved in the metabolism of monoterpenoids. Twenty-two selected biotransformations were used to predict the metabolism of camphene, camphor, carvacrol, carvone, 1,4-cineole, 1,8-cineole, citral, citronellal, cuminaldehyde, p-cymene, fenchone, geraniol, limonene, linalool, menthol, myrcene, nootkatone, perillyl alcohol, pinene, pulegone, terpinen-4-ol and thymol. In parallel, Wistar rats received a chemically defined diet with or without 0.05% of the referred compounds. Before and after 5 days of the exposure to the dietary monoterpenes, urine was collected and untargeted metabolomics analysis performed using high-resolution mass spectrometry (UPLC-QToF). On average, 10 metabolites per compound were identified in rat urine, including new and known ones. Identification of metabolites was based on monoisotopic mass and formula match, presence of adducts and specific mass losses indicative of glucuronidation and conjugation to amino acids. Validation of identification is being done using orbitrap MS/MS and hydrogen-deuterium exchange experiments. The combination of in silico prediction and in vivo experiment allowed the identification of known and new metabolites of different dietary terpenoids. Predicted metabolites of terpenes will be added in PhytoHub to complement the database of known metabolites. Acknowledgement : Agence Nationale de la Recherche - FoodBAll project (JPI HDHL)" @default.
- W3136124560 created "2021-03-29" @default.
- W3136124560 creator A5006231307 @default.
- W3136124560 creator A5016616599 @default.
- W3136124560 creator A5027504288 @default.
- W3136124560 creator A5046607944 @default.
- W3136124560 creator A5081075111 @default.
- W3136124560 date "2017-08-22" @default.
- W3136124560 modified "2023-09-23" @default.
- W3136124560 title "IN SILICO PREDICTION OF METABOLISM AS A TOOL TO IDENTIFY NEW METABOLITES OF DIETARY MONOTERPENES IN RATS" @default.
- W3136124560 doi "https://doi.org/10.14748/ssp.v4i1.3945" @default.
- W3136124560 hasPublicationYear "2017" @default.
- W3136124560 type Work @default.
- W3136124560 sameAs 3136124560 @default.
- W3136124560 citedByCount "0" @default.
- W3136124560 crossrefType "journal-article" @default.
- W3136124560 hasAuthorship W3136124560A5006231307 @default.
- W3136124560 hasAuthorship W3136124560A5016616599 @default.
- W3136124560 hasAuthorship W3136124560A5027504288 @default.
- W3136124560 hasAuthorship W3136124560A5046607944 @default.
- W3136124560 hasAuthorship W3136124560A5081075111 @default.
- W3136124560 hasConcept C178790620 @default.
- W3136124560 hasConcept C185592680 @default.
- W3136124560 hasConcept C2776134268 @default.
- W3136124560 hasConcept C2777278459 @default.
- W3136124560 hasConcept C2777477808 @default.
- W3136124560 hasConcept C2777861070 @default.
- W3136124560 hasConcept C2778240251 @default.
- W3136124560 hasConcept C2778279090 @default.
- W3136124560 hasConcept C2778829202 @default.
- W3136124560 hasConcept C2779729912 @default.
- W3136124560 hasConcept C2780642067 @default.
- W3136124560 hasConcept C2780676017 @default.
- W3136124560 hasConcept C2780697445 @default.
- W3136124560 hasConcept C43617362 @default.
- W3136124560 hasConcept C44937612 @default.
- W3136124560 hasConcept C55493867 @default.
- W3136124560 hasConcept C62231903 @default.
- W3136124560 hasConceptScore W3136124560C178790620 @default.
- W3136124560 hasConceptScore W3136124560C185592680 @default.
- W3136124560 hasConceptScore W3136124560C2776134268 @default.
- W3136124560 hasConceptScore W3136124560C2777278459 @default.
- W3136124560 hasConceptScore W3136124560C2777477808 @default.
- W3136124560 hasConceptScore W3136124560C2777861070 @default.
- W3136124560 hasConceptScore W3136124560C2778240251 @default.
- W3136124560 hasConceptScore W3136124560C2778279090 @default.
- W3136124560 hasConceptScore W3136124560C2778829202 @default.
- W3136124560 hasConceptScore W3136124560C2779729912 @default.
- W3136124560 hasConceptScore W3136124560C2780642067 @default.
- W3136124560 hasConceptScore W3136124560C2780676017 @default.
- W3136124560 hasConceptScore W3136124560C2780697445 @default.
- W3136124560 hasConceptScore W3136124560C43617362 @default.
- W3136124560 hasConceptScore W3136124560C44937612 @default.
- W3136124560 hasConceptScore W3136124560C55493867 @default.
- W3136124560 hasConceptScore W3136124560C62231903 @default.
- W3136124560 hasIssue "1" @default.
- W3136124560 hasLocation W31361245601 @default.
- W3136124560 hasOpenAccess W3136124560 @default.
- W3136124560 hasPrimaryLocation W31361245601 @default.
- W3136124560 hasRelatedWork W1483062248 @default.
- W3136124560 hasRelatedWork W1569146316 @default.
- W3136124560 hasRelatedWork W1971573926 @default.
- W3136124560 hasRelatedWork W1992140659 @default.
- W3136124560 hasRelatedWork W2031933043 @default.
- W3136124560 hasRelatedWork W2076110748 @default.
- W3136124560 hasRelatedWork W2089459252 @default.
- W3136124560 hasRelatedWork W2150168537 @default.
- W3136124560 hasRelatedWork W2492852399 @default.
- W3136124560 hasRelatedWork W2588093569 @default.
- W3136124560 hasRelatedWork W2957436532 @default.
- W3136124560 hasRelatedWork W3013646386 @default.
- W3136124560 hasRelatedWork W3045471581 @default.
- W3136124560 hasRelatedWork W3048001724 @default.
- W3136124560 hasRelatedWork W3087901656 @default.
- W3136124560 hasRelatedWork W3127565033 @default.
- W3136124560 hasRelatedWork W3155340321 @default.
- W3136124560 hasRelatedWork W3163245436 @default.
- W3136124560 hasRelatedWork W3195542438 @default.
- W3136124560 hasRelatedWork W955795525 @default.
- W3136124560 hasVolume "4" @default.
- W3136124560 isParatext "false" @default.
- W3136124560 isRetracted "false" @default.
- W3136124560 magId "3136124560" @default.
- W3136124560 workType "article" @default.