Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136126007> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3136126007 endingPage "15" @default.
- W3136126007 startingPage "11" @default.
- W3136126007 abstract "Mecamylamine is a nonselective antagonist of nicotinic acetylcholine receptors that was developed as an antihypertensive medication and is now being studied for its beneficial effects in several pathological conditions, such as substance abuse, depression, anxiety and epilepsy. In this work, we investigate the effect of mecamylamine on the manifestations of seizure-like activity evoked by perfusion of hippocampal slices with low-Mg2+ solution of artificial cerebrospinal fluid. Reducing Mg2+ concentration in extracellular solution induced two distinct types of epileptiform activity: recurring seizure-like activity and continuous discharges. Application of mecamylamine significantly increased internal frequency of recurring seizurelike activity and significantly decreased inter-event intervals between continuous discharges. We also show that mecamylamine significantly decreased internal frequency of continuous epileptiform discharges. The results of our work show that mecamylamine exerts modulatory effect on the low-Mg2+ epileptiform activity induced in hippocampal acute rat brain slices. Additionally, obtained results indicate the role of nicotinic acetylcholine receptors in the modulation of hippocampal network activity, which might explain some of the therapeutic effects of mecamylamine in CNS." @default.
- W3136126007 created "2021-03-29" @default.
- W3136126007 creator A5000055796 @default.
- W3136126007 creator A5013786128 @default.
- W3136126007 date "2021-01-28" @default.
- W3136126007 modified "2023-09-25" @default.
- W3136126007 title "Mecamylamine modulates epileptiform discharges in low-Mg2+ model of epilepsy" @default.
- W3136126007 cites W1969965068 @default.
- W3136126007 cites W2000273086 @default.
- W3136126007 cites W2003630255 @default.
- W3136126007 cites W2010065714 @default.
- W3136126007 cites W2016774858 @default.
- W3136126007 cites W2017374162 @default.
- W3136126007 cites W2031254878 @default.
- W3136126007 cites W2048564755 @default.
- W3136126007 cites W2053696585 @default.
- W3136126007 cites W2064088453 @default.
- W3136126007 cites W2086479915 @default.
- W3136126007 cites W2091673195 @default.
- W3136126007 cites W2127379279 @default.
- W3136126007 cites W2131349644 @default.
- W3136126007 cites W2145085490 @default.
- W3136126007 cites W2304512189 @default.
- W3136126007 cites W2587231596 @default.
- W3136126007 cites W2620611579 @default.
- W3136126007 doi "https://doi.org/10.15407/fz67.01.011" @default.
- W3136126007 hasPublicationYear "2021" @default.
- W3136126007 type Work @default.
- W3136126007 sameAs 3136126007 @default.
- W3136126007 citedByCount "0" @default.
- W3136126007 crossrefType "journal-article" @default.
- W3136126007 hasAuthorship W3136126007A5000055796 @default.
- W3136126007 hasAuthorship W3136126007A5013786128 @default.
- W3136126007 hasBestOaLocation W31361260071 @default.
- W3136126007 hasConcept C126322002 @default.
- W3136126007 hasConcept C148762608 @default.
- W3136126007 hasConcept C15744967 @default.
- W3136126007 hasConcept C169760540 @default.
- W3136126007 hasConcept C170493617 @default.
- W3136126007 hasConcept C185592680 @default.
- W3136126007 hasConcept C188987157 @default.
- W3136126007 hasConcept C2775910092 @default.
- W3136126007 hasConcept C2776880047 @default.
- W3136126007 hasConcept C2776885963 @default.
- W3136126007 hasConcept C2778186239 @default.
- W3136126007 hasConcept C2781161787 @default.
- W3136126007 hasConcept C42219234 @default.
- W3136126007 hasConcept C71924100 @default.
- W3136126007 hasConcept C98274493 @default.
- W3136126007 hasConceptScore W3136126007C126322002 @default.
- W3136126007 hasConceptScore W3136126007C148762608 @default.
- W3136126007 hasConceptScore W3136126007C15744967 @default.
- W3136126007 hasConceptScore W3136126007C169760540 @default.
- W3136126007 hasConceptScore W3136126007C170493617 @default.
- W3136126007 hasConceptScore W3136126007C185592680 @default.
- W3136126007 hasConceptScore W3136126007C188987157 @default.
- W3136126007 hasConceptScore W3136126007C2775910092 @default.
- W3136126007 hasConceptScore W3136126007C2776880047 @default.
- W3136126007 hasConceptScore W3136126007C2776885963 @default.
- W3136126007 hasConceptScore W3136126007C2778186239 @default.
- W3136126007 hasConceptScore W3136126007C2781161787 @default.
- W3136126007 hasConceptScore W3136126007C42219234 @default.
- W3136126007 hasConceptScore W3136126007C71924100 @default.
- W3136126007 hasConceptScore W3136126007C98274493 @default.
- W3136126007 hasIssue "1" @default.
- W3136126007 hasLocation W31361260071 @default.
- W3136126007 hasOpenAccess W3136126007 @default.
- W3136126007 hasPrimaryLocation W31361260071 @default.
- W3136126007 hasRelatedWork W1521272133 @default.
- W3136126007 hasRelatedWork W1910569525 @default.
- W3136126007 hasRelatedWork W2010108080 @default.
- W3136126007 hasRelatedWork W2028217898 @default.
- W3136126007 hasRelatedWork W2033768432 @default.
- W3136126007 hasRelatedWork W2042956033 @default.
- W3136126007 hasRelatedWork W2138730144 @default.
- W3136126007 hasRelatedWork W2748952813 @default.
- W3136126007 hasRelatedWork W2899084033 @default.
- W3136126007 hasRelatedWork W2989716236 @default.
- W3136126007 hasVolume "67" @default.
- W3136126007 isParatext "false" @default.
- W3136126007 isRetracted "false" @default.
- W3136126007 magId "3136126007" @default.
- W3136126007 workType "article" @default.