FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136126105> ?p ?o ?g. }

• W3136126105 endingPage "174054" @default.
• W3136126105 startingPage "174054" @default.
• W3136126105 abstract "MicroRNAs (miRNAs) are involved in the initiation and development of cancer and participate in drug resistance. Paclitaxel (PTX) is a first-line chemotherapy drug for advanced non-small cell lung cancer (NSCLC). The abnormal miRNA expression in NSCLC and its association with chemotherapy drug resistance remains largely unknown. The study aimed to investigate the aberrant expression of miR-221–3p in NSCLC and to elucidate its molecular mechanisms in relation to PTX resistance. PTX increased miR-221–3p expression and regulated MDM2/P53 expression in the PTX-sensitive NSCLC strain (A549). Meanwhile, miR-221–3p was rarely expressed and not interfered by PTX in PTX-resistant A549 cells (A549/Taxol). Dual-luciferase reporter assay confirmed that miR-221–3p specifically binds to MDM2 messenger RNA and inhibited MDM2 expression. The expression of MDM2 and P53 showed a negative correlation in NSCLC cell lines. MiR-221–3p down-regulation reduced the sensitivity of A549 cells to PTX, whereas its up-regulation partially reversed the A549/Taxol cells resistance to PTX and increased the chemosensitivity of A549/Taxol cells to PTX in xenograft models. Quantitative polymerase chain reaction analysis revealed that miR-221–3p expression increased, whereas the MDM2 level decreased in human NSCLC tumor tissues. Moreover, Western bolt analysis showed that P53 was lowly expressed in tumor tissues with MDM2 overexpression. Low expression of miR-221–3p in NSCLC tissues might indicate a poor T staging. In conclusion, miR-221–3p overexpression could regulate MDM2/p53 signaling pathway to reverse the PTX resistance of NSCLC and induce apoptosis in vitro and vivo." @default.
• W3136126105 created "2021-03-29" @default.
• W3136126105 creator A5004563088 @default.
• W3136126105 creator A5004751397 @default.
• W3136126105 creator A5012478802 @default.
• W3136126105 creator A5020240041 @default.
• W3136126105 creator A5026780331 @default.
• W3136126105 creator A5062546836 @default.
• W3136126105 creator A5075317021 @default.
• W3136126105 creator A5080283046 @default.
• W3136126105 creator A5081833653 @default.
• W3136126105 creator A5086240082 @default.
• W3136126105 date "2021-05-01" @default.
• W3136126105 modified "2023-10-08" @default.
• W3136126105 title "MiR-221-3p-mediated downregulation of MDM2 reverses the paclitaxel resistance of non-small cell lung cancer in vitro and in vivo" @default.
• W3136126105 cites W1593555249 @default.
• W3136126105 cites W1958111844 @default.
• W3136126105 cites W1996445359 @default.
• W3136126105 cites W2013536547 @default.
• W3136126105 cites W2016321198 @default.
• W3136126105 cites W2087206434 @default.
• W3136126105 cites W2096793135 @default.
• W3136126105 cites W2148251762 @default.
• W3136126105 cites W2158734599 @default.
• W3136126105 cites W2312970556 @default.
• W3136126105 cites W2531161704 @default.
• W3136126105 cites W2547984455 @default.
• W3136126105 cites W2588675203 @default.
• W3136126105 cites W2781525129 @default.
• W3136126105 cites W2791188611 @default.
• W3136126105 cites W2794240848 @default.
• W3136126105 cites W2889438018 @default.
• W3136126105 cites W2889646458 @default.
• W3136126105 cites W2922107932 @default.
• W3136126105 cites W2923885138 @default.
• W3136126105 cites W2952903152 @default.
• W3136126105 cites W2952961086 @default.
• W3136126105 cites W2954734416 @default.
• W3136126105 cites W2998770186 @default.
• W3136126105 cites W3014924469 @default.
• W3136126105 cites W3021867877 @default.
• W3136126105 cites W3153417541 @default.
• W3136126105 cites W4232733723 @default.
• W3136126105 cites W4242460399 @default.
• W3136126105 doi "https://doi.org/10.1016/j.ejphar.2021.174054" @default.
• W3136126105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33771522" @default.
• W3136126105 hasPublicationYear "2021" @default.
• W3136126105 type Work @default.
• W3136126105 sameAs 3136126105 @default.
• W3136126105 citedByCount "15" @default.
• W3136126105 countsByYear W31361261052021 @default.
• W3136126105 countsByYear W31361261052022 @default.
• W3136126105 countsByYear W31361261052023 @default.
• W3136126105 crossrefType "journal-article" @default.
• W3136126105 hasAuthorship W3136126105A5004563088 @default.
• W3136126105 hasAuthorship W3136126105A5004751397 @default.
• W3136126105 hasAuthorship W3136126105A5012478802 @default.
• W3136126105 hasAuthorship W3136126105A5020240041 @default.
• W3136126105 hasAuthorship W3136126105A5026780331 @default.
• W3136126105 hasAuthorship W3136126105A5062546836 @default.
• W3136126105 hasAuthorship W3136126105A5075317021 @default.
• W3136126105 hasAuthorship W3136126105A5080283046 @default.
• W3136126105 hasAuthorship W3136126105A5081833653 @default.
• W3136126105 hasAuthorship W3136126105A5086240082 @default.
• W3136126105 hasBestOaLocation W31361261052 @default.
• W3136126105 hasConcept C104317684 @default.
• W3136126105 hasConcept C114851261 @default.
• W3136126105 hasConcept C121608353 @default.
• W3136126105 hasConcept C127561419 @default.
• W3136126105 hasConcept C143998085 @default.
• W3136126105 hasConcept C145059251 @default.
• W3136126105 hasConcept C207001950 @default.
• W3136126105 hasConcept C2776192174 @default.
• W3136126105 hasConcept C2776256026 @default.
• W3136126105 hasConcept C2777292972 @default.
• W3136126105 hasConcept C502942594 @default.
• W3136126105 hasConcept C54355233 @default.
• W3136126105 hasConcept C55493867 @default.
• W3136126105 hasConcept C71924100 @default.
• W3136126105 hasConcept C81729549 @default.
• W3136126105 hasConcept C81885089 @default.
• W3136126105 hasConcept C86803240 @default.
• W3136126105 hasConceptScore W3136126105C104317684 @default.
• W3136126105 hasConceptScore W3136126105C114851261 @default.
• W3136126105 hasConceptScore W3136126105C121608353 @default.
• W3136126105 hasConceptScore W3136126105C127561419 @default.
• W3136126105 hasConceptScore W3136126105C143998085 @default.
• W3136126105 hasConceptScore W3136126105C145059251 @default.
• W3136126105 hasConceptScore W3136126105C207001950 @default.
• W3136126105 hasConceptScore W3136126105C2776192174 @default.
• W3136126105 hasConceptScore W3136126105C2776256026 @default.
• W3136126105 hasConceptScore W3136126105C2777292972 @default.
• W3136126105 hasConceptScore W3136126105C502942594 @default.
• W3136126105 hasConceptScore W3136126105C54355233 @default.
• W3136126105 hasConceptScore W3136126105C55493867 @default.
• W3136126105 hasConceptScore W3136126105C71924100 @default.
• W3136126105 hasConceptScore W3136126105C81729549 @default.
• W3136126105 hasConceptScore W3136126105C81885089 @default.

• next