FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136127758> ?p ?o ?g. }

• W3136127758 endingPage "9187" @default.
• W3136127758 startingPage "9176" @default.
• W3136127758 abstract "Insomnia is an anabatic epidemiology, while the mechanism is extremely complicated; it remains one of the major scientific challenges in life sciences. Because of the advantage of having a similar genetic background and circadian rhythm as those of humans, the Drosophila melanogaster model organism is hugely popular in sleep-related drug screening studies. Seven-day-old virgin D. melanogaster was used to establish the sleep deprivation model by repeated light stimulation at night. Using PySolo activity monitoring system and Drosophila activity as indices, the effective fractions of Zhi-Zi-Hou-Po decoction (ZZHPD) for insomnia were screened; the content of monoamine neurotransmitters dopamine (DA), 5-hydroxyindole-3-acetic acid (5-HIAA), Homovanillic acid (HVA), and 5-hydroxytryptamine (5-HT) in the brain of D. melanogaster were determined by high-performance liquid chromatography-electro-chemical detection. The herb-compound-target-disease target network were further constructed through network pharmacology to identify the potential targets and pathways of ZZHPD in the intervention of insomnia. Finally, the molecular docking method was used for evaluating the binding characteristics of important compounds from ZZHPD with related targets. The results showed that a certain dose of ZZHPD and its petroleum ether, dichloromethane, ethyl acetate, and n-butanol fractions could improve sleep. The dichloromethane fraction from ZZHPD extracts showed the best anti-insomnia effect among all extracts. It can also reduce the content of DA and HVA in the brain of D. melanogaster and increase 5-HT and 5-HIAA levels. The network pharmacology showed that the main active ingredients in ZZHPD included magnolol, honokiol, hesperidin, and so forth. According to the screening conditions, there were 71 targets and the result of KEGG enrichment analysis revealed that 73 pathways were associated with insomnia, which were primarily involved in inflammatory response, central neurotransmitter regulation, and apoptosis to relieve insomnia. The molecular docking results clarified that naringenin and apigenin have an intimate relationship with GABAA receptor, histamine H1, orexin receptor type 2, and interleukin-6. The mechanism of relieving insomnia is the result of the interaction of multi-components, multi-targets, and multi-pathways, which provides a certain theoretical basis for the treatment of insomnia and related diseases as well as clinical research." @default.
• W3136127758 created "2021-03-29" @default.
• W3136127758 creator A5008366169 @default.
• W3136127758 creator A5013027100 @default.
• W3136127758 creator A5021118179 @default.
• W3136127758 creator A5021825716 @default.
• W3136127758 creator A5042505190 @default.
• W3136127758 creator A5069006538 @default.
• W3136127758 creator A5070102803 @default.
• W3136127758 creator A5082372690 @default.
• W3136127758 creator A5086127573 @default.
• W3136127758 creator A5089488228 @default.
• W3136127758 creator A5090323662 @default.
• W3136127758 date "2021-03-24" @default.
• W3136127758 modified "2023-10-18" @default.
• W3136127758 title "Integrated Screening of Effective Anti-Insomnia Fractions of Zhi-Zi-Hou-Po Decoction via <i>Drosophila melanogaster</i> and Network Pharmacology Analysis of the Underlying Pharmacodynamic Material and Mechanism" @default.
• W3136127758 cites W1562600987 @default.
• W3136127758 cites W1568243410 @default.
• W3136127758 cites W1787237586 @default.
• W3136127758 cites W2002734515 @default.
• W3136127758 cites W2017269992 @default.
• W3136127758 cites W2027717266 @default.
• W3136127758 cites W2067786443 @default.
• W3136127758 cites W2084848253 @default.
• W3136127758 cites W2097744565 @default.
• W3136127758 cites W2124679671 @default.
• W3136127758 cites W2131802378 @default.
• W3136127758 cites W2522224486 @default.
• W3136127758 cites W2618209086 @default.
• W3136127758 cites W2736172938 @default.
• W3136127758 cites W2741356598 @default.
• W3136127758 cites W2749006997 @default.
• W3136127758 cites W2750434287 @default.
• W3136127758 cites W2752981360 @default.
• W3136127758 cites W2756424852 @default.
• W3136127758 cites W2769893030 @default.
• W3136127758 cites W2774220947 @default.
• W3136127758 cites W2782658406 @default.
• W3136127758 cites W2791785738 @default.
• W3136127758 cites W2796121622 @default.
• W3136127758 cites W2803304487 @default.
• W3136127758 cites W2807497371 @default.
• W3136127758 cites W2807614514 @default.
• W3136127758 cites W2886684824 @default.
• W3136127758 cites W2889710034 @default.
• W3136127758 cites W2903158776 @default.
• W3136127758 cites W2908018414 @default.
• W3136127758 cites W2910980224 @default.
• W3136127758 cites W2938190906 @default.
• W3136127758 cites W2950764390 @default.
• W3136127758 cites W2957931514 @default.
• W3136127758 cites W2971801381 @default.
• W3136127758 cites W2981441401 @default.
• W3136127758 cites W2982157088 @default.
• W3136127758 cites W2989732577 @default.
• W3136127758 cites W2991541757 @default.
• W3136127758 cites W3008650759 @default.
• W3136127758 cites W3017386619 @default.
• W3136127758 cites W3029132738 @default.
• W3136127758 cites W3046157566 @default.
• W3136127758 cites W4293767581 @default.
• W3136127758 doi "https://doi.org/10.1021/acsomega.1c00445" @default.
• W3136127758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8028125" @default.
• W3136127758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33842786" @default.
• W3136127758 hasPublicationYear "2021" @default.
• W3136127758 type Work @default.
• W3136127758 sameAs 3136127758 @default.
• W3136127758 citedByCount "6" @default.
• W3136127758 countsByYear W31361277582021 @default.
• W3136127758 countsByYear W31361277582022 @default.
• W3136127758 countsByYear W31361277582023 @default.
• W3136127758 crossrefType "journal-article" @default.
• W3136127758 hasAuthorship W3136127758A5008366169 @default.
• W3136127758 hasAuthorship W3136127758A5013027100 @default.
• W3136127758 hasAuthorship W3136127758A5021118179 @default.
• W3136127758 hasAuthorship W3136127758A5021825716 @default.
• W3136127758 hasAuthorship W3136127758A5042505190 @default.
• W3136127758 hasAuthorship W3136127758A5069006538 @default.
• W3136127758 hasAuthorship W3136127758A5070102803 @default.
• W3136127758 hasAuthorship W3136127758A5082372690 @default.
• W3136127758 hasAuthorship W3136127758A5086127573 @default.
• W3136127758 hasAuthorship W3136127758A5089488228 @default.
• W3136127758 hasAuthorship W3136127758A5090323662 @default.
• W3136127758 hasBestOaLocation W31361277581 @default.
• W3136127758 hasConcept C104317684 @default.
• W3136127758 hasConcept C126322002 @default.
• W3136127758 hasConcept C185592680 @default.
• W3136127758 hasConcept C190409667 @default.
• W3136127758 hasConcept C2776998849 @default.
• W3136127758 hasConcept C2780104201 @default.
• W3136127758 hasConcept C513476851 @default.
• W3136127758 hasConcept C55493867 @default.
• W3136127758 hasConcept C556039675 @default.
• W3136127758 hasConcept C71924100 @default.
• W3136127758 hasConcept C98274493 @default.
• W3136127758 hasConceptScore W3136127758C104317684 @default.
• W3136127758 hasConceptScore W3136127758C126322002 @default.
• W3136127758 hasConceptScore W3136127758C185592680 @default.

• next