Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136127986> ?p ?o ?g. }
- W3136127986 endingPage "100996" @default.
- W3136127986 startingPage "100996" @default.
- W3136127986 abstract "The combination of chemotherapy/photodynamic therapy (PDT) has shown synergistically enhanced anticancer efficacies. However, precise delivery of therapeutic agents to the site-of-action and activation of PDT in deep tissues are still challenging. Herein, a poly [oligo (ethylene glycol) methyl ether methacrylate] (polyOEGMA)-functionalized dendritic polymer-paclitaxel prodrug with a hydrophobic core was designed and prepared to encapsulate pyropheophorbide a (PPa) and an imidazole derivative, two-photon (TP) absorption compound T1. As a short peptide GFLG that was sensitive to intracellular cathepsin B was inserted into the branches of the dendritic polymer and also used as a linker to conjugate paclitaxel (PTX) to the polymer, the nanosystem released PTX in a tumor microenvironment-responsive manner and was partially degraded. The TP compound T1 had a high energy-transfer efficiency and displayed an enhanced two-photon photodynamic therapy (TP-PDT) effect, thus resulting in an increased anticancer efficacy, which was confirmed with the results of in situ TP-PDT anti-tumor efficiencies and apoptosis assays. The synergistic effect on inhibition of tumor growth in the 4T1 xenograft mice was achieved due to the combination of chemotherapy (PTX) and PDT (PPa or TP-PDT compound T1). Importantly, the chemo/TP-PDT combined system achieved a much higher tumor growth inhibition (TGI, 67.23%) in the tissue surrounded with thick swine muscle as compared to the group treated with PTX and PPa (48.92%). The prodrug-based nanosystem loaded with PTX and TP-PDT agents could overcome the challenge of conventional one-photon PDT with a short penetration depth into tissues to achieve a notably enhanced synergistic anticancer efficacy." @default.
- W3136127986 created "2021-03-29" @default.
- W3136127986 creator A5000979147 @default.
- W3136127986 creator A5009121661 @default.
- W3136127986 creator A5018057046 @default.
- W3136127986 creator A5025842336 @default.
- W3136127986 creator A5043200545 @default.
- W3136127986 creator A5044581649 @default.
- W3136127986 creator A5058435392 @default.
- W3136127986 creator A5069052576 @default.
- W3136127986 creator A5071370948 @default.
- W3136127986 creator A5074335599 @default.
- W3136127986 creator A5084203896 @default.
- W3136127986 date "2021-06-01" @default.
- W3136127986 modified "2023-10-16" @default.
- W3136127986 title "An intracellular enzyme-responsive polymeric prodrug with synergistic effect of chemotherapy and two-photon photodynamic therapy" @default.
- W3136127986 cites W1832305751 @default.
- W3136127986 cites W1967201601 @default.
- W3136127986 cites W1970654706 @default.
- W3136127986 cites W1976041621 @default.
- W3136127986 cites W1976282388 @default.
- W3136127986 cites W1976589118 @default.
- W3136127986 cites W1984499404 @default.
- W3136127986 cites W1987531894 @default.
- W3136127986 cites W1988652490 @default.
- W3136127986 cites W1990687831 @default.
- W3136127986 cites W1995765722 @default.
- W3136127986 cites W1998362644 @default.
- W3136127986 cites W2000772217 @default.
- W3136127986 cites W2002827632 @default.
- W3136127986 cites W2005033237 @default.
- W3136127986 cites W2006954662 @default.
- W3136127986 cites W2014393145 @default.
- W3136127986 cites W2015886513 @default.
- W3136127986 cites W2021876818 @default.
- W3136127986 cites W2026712777 @default.
- W3136127986 cites W2058406938 @default.
- W3136127986 cites W2068765155 @default.
- W3136127986 cites W2068920186 @default.
- W3136127986 cites W2074693197 @default.
- W3136127986 cites W2083073535 @default.
- W3136127986 cites W2094449638 @default.
- W3136127986 cites W2101101478 @default.
- W3136127986 cites W2109493059 @default.
- W3136127986 cites W2118213449 @default.
- W3136127986 cites W2123050379 @default.
- W3136127986 cites W2127410754 @default.
- W3136127986 cites W2152280976 @default.
- W3136127986 cites W2200101803 @default.
- W3136127986 cites W2319984943 @default.
- W3136127986 cites W2327725770 @default.
- W3136127986 cites W2553430827 @default.
- W3136127986 cites W2787938844 @default.
- W3136127986 cites W2794205989 @default.
- W3136127986 cites W2800928500 @default.
- W3136127986 cites W2805760201 @default.
- W3136127986 cites W2905828059 @default.
- W3136127986 cites W2905929082 @default.
- W3136127986 cites W2913612273 @default.
- W3136127986 cites W2937833541 @default.
- W3136127986 cites W2955788509 @default.
- W3136127986 cites W2965518480 @default.
- W3136127986 cites W2969159587 @default.
- W3136127986 cites W2975131189 @default.
- W3136127986 cites W2985184075 @default.
- W3136127986 cites W2991252149 @default.
- W3136127986 cites W2994911282 @default.
- W3136127986 cites W3001175968 @default.
- W3136127986 cites W3041560952 @default.
- W3136127986 cites W3048619780 @default.
- W3136127986 cites W3048942453 @default.
- W3136127986 cites W3112518054 @default.
- W3136127986 doi "https://doi.org/10.1016/j.apmt.2021.100996" @default.
- W3136127986 hasPublicationYear "2021" @default.
- W3136127986 type Work @default.
- W3136127986 sameAs 3136127986 @default.
- W3136127986 citedByCount "10" @default.
- W3136127986 countsByYear W31361279862021 @default.
- W3136127986 countsByYear W31361279862022 @default.
- W3136127986 crossrefType "journal-article" @default.
- W3136127986 hasAuthorship W3136127986A5000979147 @default.
- W3136127986 hasAuthorship W3136127986A5009121661 @default.
- W3136127986 hasAuthorship W3136127986A5018057046 @default.
- W3136127986 hasAuthorship W3136127986A5025842336 @default.
- W3136127986 hasAuthorship W3136127986A5043200545 @default.
- W3136127986 hasAuthorship W3136127986A5044581649 @default.
- W3136127986 hasAuthorship W3136127986A5058435392 @default.
- W3136127986 hasAuthorship W3136127986A5069052576 @default.
- W3136127986 hasAuthorship W3136127986A5071370948 @default.
- W3136127986 hasAuthorship W3136127986A5074335599 @default.
- W3136127986 hasAuthorship W3136127986A5084203896 @default.
- W3136127986 hasConcept C108215921 @default.
- W3136127986 hasConcept C12554922 @default.
- W3136127986 hasConcept C134306372 @default.
- W3136127986 hasConcept C178790620 @default.
- W3136127986 hasConcept C185592680 @default.
- W3136127986 hasConcept C192562407 @default.
- W3136127986 hasConcept C197336794 @default.