Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136129197> ?p ?o ?g. }
- W3136129197 endingPage "2987" @default.
- W3136129197 startingPage "2987" @default.
- W3136129197 abstract "Osteoarthritis (OA) is a common degenerative disease that results in joint inflammation as well as pain and stiffness. A previous study has reported that Cornus officinalis (CO) extract inhibits oxidant activities and oxidative stress in RAW 264.7 cells. In the present study, we isolated bioactive compound(s) by fractionating the CO extract to elucidate its antiosteoarthritic effects. A single bioactive component, morroniside, was identified as a potential candidate. The CO extract and morroniside exhibited antiosteoarthritic effects by downregulating factors associated with cartilage degradation, including cyclooxygenase-2 (Cox-2), matrix metalloproteinase 3 (Mmp-3), and matrix metalloproteinase 13 (Mmp-13), in interleukin-1 beta (IL-1β)-induced chondrocytes. Furthermore, morroniside prevented prostaglandin E2 (PGE2) and collagenase secretion in IL-1β-induced chondrocytes. In the destabilization of the medial meniscus (DMM)-induced mouse osteoarthritic model, morroniside administration attenuated cartilage destruction by decreasing expression of inflammatory mediators, such as Cox-2, Mmp3, and Mmp13, in the articular cartilage. Transverse microcomputed tomography analysis revealed that morroniside reduced DMM-induced sclerosis in the subchondral bone plate. These findings suggest that morroniside may be a potential protective bioactive compound against OA pathogenesis." @default.
- W3136129197 created "2021-03-29" @default.
- W3136129197 creator A5001663396 @default.
- W3136129197 creator A5025941229 @default.
- W3136129197 creator A5043307609 @default.
- W3136129197 creator A5045973297 @default.
- W3136129197 creator A5056425639 @default.
- W3136129197 creator A5058250056 @default.
- W3136129197 creator A5063924395 @default.
- W3136129197 creator A5074548240 @default.
- W3136129197 creator A5075764296 @default.
- W3136129197 creator A5078173247 @default.
- W3136129197 date "2021-03-15" @default.
- W3136129197 modified "2023-10-08" @default.
- W3136129197 title "Antiosteoarthritic Effect of Morroniside in Chondrocyte Inflammation and Destabilization of Medial Meniscus-Induced Mouse Model" @default.
- W3136129197 cites W1511359292 @default.
- W3136129197 cites W1798991985 @default.
- W3136129197 cites W1884436975 @default.
- W3136129197 cites W1964067403 @default.
- W3136129197 cites W1975246967 @default.
- W3136129197 cites W1977524265 @default.
- W3136129197 cites W1980059807 @default.
- W3136129197 cites W1990794351 @default.
- W3136129197 cites W2003328208 @default.
- W3136129197 cites W2005008958 @default.
- W3136129197 cites W2031118527 @default.
- W3136129197 cites W2058898205 @default.
- W3136129197 cites W2071886638 @default.
- W3136129197 cites W2075748605 @default.
- W3136129197 cites W2091408108 @default.
- W3136129197 cites W2115173002 @default.
- W3136129197 cites W2134945818 @default.
- W3136129197 cites W2155547066 @default.
- W3136129197 cites W2155671648 @default.
- W3136129197 cites W2467995164 @default.
- W3136129197 cites W2561285627 @default.
- W3136129197 cites W2575417832 @default.
- W3136129197 cites W2578679094 @default.
- W3136129197 cites W2623267344 @default.
- W3136129197 cites W2741810577 @default.
- W3136129197 cites W2752563562 @default.
- W3136129197 cites W2803061758 @default.
- W3136129197 cites W2806798661 @default.
- W3136129197 cites W2886676918 @default.
- W3136129197 cites W2889494801 @default.
- W3136129197 cites W2892300970 @default.
- W3136129197 cites W2903534860 @default.
- W3136129197 cites W2913088414 @default.
- W3136129197 cites W2923994867 @default.
- W3136129197 cites W2947959660 @default.
- W3136129197 cites W2949126234 @default.
- W3136129197 cites W2996365566 @default.
- W3136129197 cites W2998166408 @default.
- W3136129197 cites W3006981518 @default.
- W3136129197 cites W3035661202 @default.
- W3136129197 cites W3036542027 @default.
- W3136129197 cites W3082557756 @default.
- W3136129197 cites W3089196906 @default.
- W3136129197 cites W3092086038 @default.
- W3136129197 cites W3094957186 @default.
- W3136129197 cites W3097164660 @default.
- W3136129197 cites W3113579456 @default.
- W3136129197 cites W3115101821 @default.
- W3136129197 cites W3115793116 @default.
- W3136129197 cites W3118192269 @default.
- W3136129197 cites W4210254819 @default.
- W3136129197 doi "https://doi.org/10.3390/ijms22062987" @default.
- W3136129197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7999654" @default.
- W3136129197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33804203" @default.
- W3136129197 hasPublicationYear "2021" @default.
- W3136129197 type Work @default.
- W3136129197 sameAs 3136129197 @default.
- W3136129197 citedByCount "12" @default.
- W3136129197 countsByYear W31361291972021 @default.
- W3136129197 countsByYear W31361291972022 @default.
- W3136129197 countsByYear W31361291972023 @default.
- W3136129197 crossrefType "journal-article" @default.
- W3136129197 hasAuthorship W3136129197A5001663396 @default.
- W3136129197 hasAuthorship W3136129197A5025941229 @default.
- W3136129197 hasAuthorship W3136129197A5043307609 @default.
- W3136129197 hasAuthorship W3136129197A5045973297 @default.
- W3136129197 hasAuthorship W3136129197A5056425639 @default.
- W3136129197 hasAuthorship W3136129197A5058250056 @default.
- W3136129197 hasAuthorship W3136129197A5063924395 @default.
- W3136129197 hasAuthorship W3136129197A5074548240 @default.
- W3136129197 hasAuthorship W3136129197A5075764296 @default.
- W3136129197 hasAuthorship W3136129197A5078173247 @default.
- W3136129197 hasBestOaLocation W31361291971 @default.
- W3136129197 hasConcept C104317684 @default.
- W3136129197 hasConcept C105702510 @default.
- W3136129197 hasConcept C109523444 @default.
- W3136129197 hasConcept C126322002 @default.
- W3136129197 hasConcept C142724271 @default.
- W3136129197 hasConcept C150194340 @default.
- W3136129197 hasConcept C185592680 @default.
- W3136129197 hasConcept C203014093 @default.
- W3136129197 hasConcept C204787440 @default.
- W3136129197 hasConcept C2776151105 @default.