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• W3136130150 abstract "<b><i>Introduction:</i></b> Breast cancer is a heterogeneous and multifactorial disease. <i>TP53</i> and <i>PAI-1</i> as important tumor suppressor genes are involved in the development, invasion, and metastasis of many cancers. This study’s objective was to demonstrate the combined genotype effects of these 2 genes by investigating their single nucleotide polymorphisms. <b><i>Methods:</i></b> In this case-control study, 200 individuals with breast cancer and 179 healthy individuals were studied. The genotypes were determined using the tetra-ARMS method. For data analysis, MDR, online javstat statistics package, and SPSS v.24 software were used. Also, in silico studies on the estimated effects of each of these polymorphisms were performed. <b><i>Results:</i></b> We showed a novel gene-gene interaction of these 2 genes and demonstrated a strong synergistic interaction for <i>TP53/PAI-1</i>, moderate synergistic interaction for <i>PAI-1</i>/age, and correlation for <i>TP53</i>/age. On the other hand, there was no association between the allelic and genotype frequency alone and in combination, with case-control status, using the parametric method, between <i>TP53</i> and <i>PAI-1</i>. <b><i>Discussion/Conclusion:</i></b> Our findings suggest that the polymorphism of codon 72 of the <i>TP53</i> gene was significantly associated with tumor stage (<i>p</i> &#x3c; 0.023). In conclusion, we showed a gene-gene interaction between <i>TP53</i> and <i>PAI-1</i>, in combination, using the MDR method." @default.
• W3136130150 created "2021-03-29" @default.
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• W3136130150 date "2020-01-01" @default.
• W3136130150 modified "2023-10-05" @default.
• W3136130150 title "Combined Genotype Effects of <b><i>TP53</i></b> and <b><i>PAI-1</i></b> Polymorphisms in Breast Cancer Susceptibility: Multifactor Dimensionality Reduction and in silico Analysis" @default.
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• W3136130150 doi "https://doi.org/10.1159/000514398" @default.
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